Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

Lee, P. D. K.; Giudice, L. C.; Conover, C. A.; Powell, D. R.

doi:10.3181/00379727-216-44182

Cited by 538Growth Hormone and Insulin-like Growth FactorsFibroblast Growth Factor ResearchLiver physiology and pathology

Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

Lee, P. D. K., Giudice, L. C., Conover, C. A., Powell, D. R.·1997·Experimental Biology and Medicine

DOI 10.3181/00379727-216-44182

Open this paper in CoChat — free account

Abstract

In 1988, insulin-like growth factor-binding protein-1 (IGFBP-1) became the first characterized member of a group of structurally related soluble proteins which specifically bind and modulate the actions of the IGFs. Since then, a wealth of information has accumulated regarding the physiology of this dynamic serum protein. In this review, we update our 1993 summary (Lee PDK et al. Proc Soc Exp Biol Med 204:4-29) of the status of IGFBP-1 research. The IGFBP-1 protein sequence contains 12 N-terminal and 6 C-terminal cysteine residues which are conserved in other mammalian IGFBP-1 sequences and amongst other IGFBPs; both of the cysteine-rich regions are required for optimal IGF binding. The nonconserved IGFBP-1 midregion may act as both a hinge which defines ligand binding characteristics and as a specific target for protease activity. Integrin-binding and phosphorylation sites within the IGFBP-1 sequence have functional significance in vitro, but their physiologic relevance in vivo have not been defined. The human IGFBP-1 and IGFBP-3 genes are contiguous and located in close proximity to the homeobox A (HOXA) gene cluster on chromosome 7. The other IGFBP genes, located on chromosomes 2, 12, and 17, are also associated with HOX clusters, suggesting evolutionary linkage of the IGFBP and HOX gene families. Similarities between the hlGFBP-1 and phosphoenolpyruvate kinase (PEPCK) promoters, including regions conferring insulin, glucocorticoid, and cyclic adenosine-monophosphate responses, are consistent with our previous hypothesis that IGFBP-1 is involved in regulation of glucose metabolism. The tissue-specific patterns of IGFBP-1 gene expression in liver, kidney, decidua, and ovary may be due to stimulation of IGFBP-1 transcription by hepatic nuclear factor 1 (HNF1) proteins. Clinical and basic studies of IGFBP-1 physiology have been aided by several recently developed assay methods. Numerous investigations have confirmed that insulin, via inhibition of IGFBP-1 transcription, is the primary determinant of IGFBP-1 expression both in vitro and in viva IGF-I and IGF-II also have specific inhibitory effects on IGFBP-1 expression. Glucocorticoids and cAMP stimulate IGFBP-1 transcription, but these effects are observed only in conditions of low or absent insulin effect. Other stimulants of IGFBP-1 expression include thyroid hormones and epidermal growth factor. Phorbol ester stimulation of IGFBP-1 expression can supersede the effects of insulin in vitro; however, the mechanism and in vivo correlates of this effect have not been determined. Cytokines and, perhaps, growth hormones may affect IGFBP-1 expression, perhaps by altering the regulatory actions of insulin; this effect may have important clinical relevance. IGFBP-1 expression is upregulated in liver and (nonhuman) kidney during postinjury regeneration. The IGF-inhibitory actions of IGFBP-1 has been confirmed by numerous in vitro studies and several in vivo animal investigations, including administration of recombinant IGFBP-1 and IGFBP-1 transgenic models. IGFBP-1 has been shown to inhibit somatic linear growth, weight gain, tissue growth, and glucose metabolism. Moreover, IGFBP-1 appears to be a primary determinant of free IGF-I levels in serum. Excess levels of IGFBP-1 may contribute to growth failure in intrauterine growth restriction and in pediatric chronic renal failure, while low IGFBP-1 levels are associated with obesity and with cardiovascular risk factors in insulin resistance syndromes. Serum IGFBP-1 measurements may be useful biochemical marker in these pathologic conditions. IGFBP-1 is expressed in decidualized stromal cells of the uterine endometrium and in ovarian granulosa cells. IGFBP-1, together with IGFs, insulin, ovarian steroids, cytokines, and other factors, is involved in a complex system which regulates menstrual cycles, ovulation, decidualization, blastocyst implantation, and fetal growth. Models for the role of IGFBP-1 in female reproductive physiology are presented, and evidence for pathophysiologic roles in pre-eclampsia, polycystic ovarian syndrome, and uterine malignancy are reviewed. Very recent data indicates that IGFBP-1 undergoes regulated expression in human osteoblasts. Limited information also suggests that IGFBP-1 may be present in peripheral neurons, and that serum IGFBP-1 may increase during exercise and in critical ilIness. In summary, two major roles for IGFBP-1 in normal physiology can be constructed from current data: (i) As an “endocrine” factor, IGFBP-1 regulates the bio-availability of serum IGF-I, thereby modulating IGF-mediated tissue metabolism. The dominant regulation of IGFBP-1 expression by meal-related changes in hepatic insulin concentrations provides a dynamic link to substrate availability. (ii) As an autocrine/paracrine factor, IGFBP-1 appears to play a crucial role in the female reproductive system and, in particular, the sequence of events leading from ovulation to implantation to successful fetal outcom

Integrity signals

Registry

Crossref · 10.3181/00379727-216-44182

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Igfbp1 has been proposed as an acute regulator of IGF-1 bioactivity.
“Igfbp1 has been proposed as an acute regulator of IGF-1 bioactivity 35 and its elevation in association with HB treatment is unclear.”
From Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells (2011) · cites this paper as [35]

Sorted by citations

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression
Yu, H. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.18.1472 · Cited by 1,433 · see citing works
The sirtuin SIRT6 regulates lifespan in male mice
Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works
Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.
Kaaks, R., Lukanova, A., & Kurzer, M. S. (2002) · PubMed · Cited by 1,038 · see citing works
The Insulin-Related Ovarian Regulatory System in Health and Disease
Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0374 · Cited by 839 · see citing works
Self-citation
Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805 · see citing works
The biology of white adipocyte proliferation
Hausman, D. B., DiGirolamo, M., Bartness, T. J., Hausman, G., & Martin, R. J. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00042.x · Cited by 710 · see citing works
Energy balance and cancer: the role of insulin and insulin-like growth factor-I
Kaaks, R., & Lukanova, A. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200070 · Cited by 615 · see citing works
“Also IGFBP-1 has been shown to have important growth regulatory (and anti-tumour) effects in a number of cell types (Lee et al. 1997; Rutanen, 1998).”
Background
Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span
Coschigano, K. T., Holland, A. N., Riders, M. E., List, E. O., Flyvbjerg, A., & Kopchick, J. J. (2003) · Endocrinology · doi:10.1210/en.2003-0374 · Cited by 510 · see citing works
FoxO1 Regulates Multiple Metabolic Pathways in the Liver
Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D. R., Le, J., Klotsas, A., Matika, R. W., Xiao, X., Franks, R. R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600272200 · Cited by 517 · see citing works
Self-citation
Insulin, Insulin-Like Growth Factor-I (IGF-I), IGF Binding Proteins, Their Biologic Interactions, and Colorectal Cancer
Sandhu, M. S. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.13.972 · Cited by 495 · see citing works
The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain
Russo, V. C., Gluckman, P. D., Feldman, E. L., & Werther, G. A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0024 · Cited by 488 · see citing works
“IGFBP-1 is known to inhibit somatic linear growth, weight gain, tissue growth, and glucose metabolism (293).”
Background
Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study
Sandhu, M. S., Heald, A. H., Gibson, J. M., Cruickshank, J. K., Dunger, D. B., & Wareham, N. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08655-5 · Cited by 470 · see citing works
The Role of Liver-Derived Insulin-Like Growth Factor-I
Ohlsson, C., Mohan, S., Sjögren, K., Tivesten, Å., Isgaard, J., Isaksson, O. G. P., Jansson, J., & Svensson, J. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0010 · Cited by 448 · see citing works
“IGFBP-1, one of the IGFBPs that also may exert IGF-I independent effects (343), increases rapidly after partial hepatectomy (344).”
Background
Novel pathways for implantation and establishment and maintenance of pregnancy in mammals
Bazer, F. W., Wu, G., Spencer, T. E., Johnson, G. A., Burghardt, R. C., & Bayless, K. J. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap095 · Cited by 376 · see citing works
“…distinct tissue that produces hormones, promotes nutrition of conceptuses, prevents fetal allograft rejection and regulates placentation by limiting Tr invasion through generation of a local cytokine environment which promotes Tr attachment over invasion (Lee et al., 1997; Irwin and Giudice, 1999).”
Background
The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study
Laughlin, G. A., Barrett-Connor, E., Criqui, M. H., & Kritz-Silverstein, D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030967 · Cited by 374 · see citing works
Fasting glucose is a risk factor for breast cancer: a prospective study.
Muti, P. C., Quattrin, T., Grant, B. J. B., Krogh, V., Micheli, A., Schünemann, H. J., Ram, M., Freudenheim, J. L., Sieri, S., Trevisan, M., et al. (2002) · PubMed · Cited by 358 · see citing works
Free insulin-like growth factors – measurements and relationships to growth hormone secretion and glucose homeostasis
Frystyk, J. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.06.001 · Cited by 336 · see citing works
“The rapid and dynamic changes in IGFBP-1 observed in relation to fasting, meal-intake and insulin-induced hypoglycemia [67,222] suggest that this binding protein play an important role as a counter-regulatory agent in glucose homeostasis by adjusting the glucose lowering activity of free IGF-I (and -II) to short-term…”
Background
Minireview. Osteopontin: Roles in Implantation and Placentation1
Johnson, G., Burghardt, R., Bazer, F., & Spencer, T. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.020651 · Cited by 315 · see citing works
Long‐lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
Rimondini, R., Arlinde, C., Sommer, W. H., & Heilig, M. A. (2002) · The FASEB Journal · doi:10.1096/fj.01-0593com · Cited by 320 · see citing works
“tive regulator of IGF-BPs (54); and decreased expression of Ca(2) -ATPase (cytoplasmic Ca(2) pump), which in turn”
Background
Homozygous and Heterozygous Expression of a Novel Insulin-Like Growth Factor-I Mutation
Walenkamp, M. J. E., Karperien, M., Pereira, A. M., Hilhorst‐Hofstee, Y., van Doorn, J., Chen, J. W., Mohan, S., Denley, A., Forbes, B. E., van Duyvenvoorde, H. A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1254 · Cited by 314 · see citing works
Gut and the Induction of Immune Tolerance in Type 1 Diabetes
Vaarala, O. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199909/10)15:5 · Cited by 47 · see citing works
Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome
Leo, V. D., Marca, A. L., & Petraglia, F. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0015 · Cited by 288 · see citing works
IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis
Wheatcroft, S. B., & Kearney, M. T. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.01.002 · Cited by 278 · see citing works
Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health
Owino, V. O., Ahmed, T., Freemark, M., Kelly, P. M., Loy, A., MANARY, M. J., & Loechl, C. (2016) · PEDIATRICS · doi:10.1542/peds.2016-0641 · Cited by 280 · see citing works
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
Rogatsky, I., Wang, J.-C., Derynck, M. K., Nonaka, D. F., Khodabakhsh, D. B., Haqq, C. M., Darimont, B. D., Garabedian, M. J., & Yamamoto, K. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336092100 · Cited by 241 · see citing works
The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
Webb, S. J., Geoghegan, T. E., Prough, R. A., & Miller, K. K. M. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600569877 · Cited by 235 · see citing works
“It is one of only a few genes that are negatively regulated by insulin, through a mechanism similar to insulin regulation of the gluconeogenic enzymes phosphoenolpyruvate carboxykinase and glucose6-phosphatase (Suwanichkul et al., 1993; Lee et al., 1997).”
Background
Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy
Smith, T. J., & Janssen, J. A. M. J. L. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00066 · Cited by 234 · see citing works
Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Kondoh, N., Wakatsuki, T., Ryo, A., Hada, A., Aihara, T., Horiuchi, S., Goseki, N., Matsubara, O., Takenaka, K., Shichita, M., et al. (1999) · PubMed · Cited by 229 · see citing works
Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia
Tazuke, S. I., Mazure, N. M., Sugawara, J., Carland, G., Faessen, G. H., Suen, L.-F., Irwin, J. C., Powell, D. R., Giaccia, A. J., & Giudice, L. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10188 · Cited by 222 · see citing works
Self-citation
Assessment of Cisplatin-Induced Nephrotoxicity by Microarray Technology
Huang, Q. (2001) · Toxicological Sciences · doi:10.1093/toxsci/63.2.196 · Cited by 221 · see citing works
“2), all of which have been associated with kidney remodeling after acute renal failure (Bohe et al. 1998; Gobe et al., 1995; Lee et al., 1997; Leonard et al., 1994; Silkensen et al., 1997).”
Background
Association of Severe Insulin Resistance With Both Loss of Limb Fat and Elevated Serum Tumor Necrosis Factor Receptor Levels in HIV Lipodystrophy
Mynarcik, D. C., McNurlan, M. A., Steigbigel, R. T., Fuhrer, J., & Gelato, M. C. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200012010-00004 · Cited by 238 · see citing works
Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors
Stadtmauer, L., Toma, S. K., Riehl, R. M., & Talbert, L. M. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01766-0 · Cited by 211 · see citing works
Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system
Kurita, T., Wang, Y. Z., Donjacour, A. A., Zhao, C., Lydon, J. P., O’Malley, B. W., Isaacs, J. T., Dahiya, R., & Cunha, G. R. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400797 · Cited by 203 · see citing works
“41 IGF signaling plays a role in growth and survival of prostatic(42) and uterine(43) epithelia, and IGFBPs antagonize IGF signaling.(44) Thus, IGFBPs are possible mediators of stromal-epithelial interactions in prostatic and uterine epithelial apoptosis.”
Background
Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations
Heald, A. H., Cruickshank, J. K., Riste, L., Cade, J. E., Anderson, S. G., Greenhalgh, A., Sampayo, J. N., Taylor, W., Fraser, W. D., White, A. E., et al. (2001) · Diabetologia · doi:10.1007/s001250051623 · Cited by 189 · see citing works
Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation
Heemskerk, V. H., Daemen, M. A. R. C., & Buurman, W. A. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00022-7 · Cited by 182 · see citing works
Insulin and Cancer
Boyd, D. B. (2003) · Integrative Cancer Therapies · doi:10.1177/1534735403259152 · Cited by 181 · see citing works
“PI3K-Akt signaling is involved in anchorage-independent cell growth61 and cell cycle entry at the G1/S transition62 and is an important survival signal inhibiting apoptosis.54,63 In addition to the direct effects of insulin at the IR, insulin inhibits hepatic synthesis of both IGFBP-1 and IGFBP-2, leading to an increa…”
Background
The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes
Haywood, N. J., Slater, T. A., Matthews, C., & Wheatcroft, S. B. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.008 · Cited by 175 · see citing works
Acanthosis Nigricans Associated with Insulin Resistance
Hermanns‐Lê, T., Scheen, A., & rard, G. R. E. P. (2004) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200405030-00008 · Cited by 162 · see citing works
Association of Severe Insulin Resistance With Both Loss of Limb Fat and Elevated Serum Tumor Necrosis Factor Receptor Levels in HIV Lipodystrophy
Mynarcik, D. C., McNurlan, M. A., Steigbigel, R. T., et al. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200012010-00004 · Cited by 165 · see citing works
Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse
Coen, M., Ruepp, S. U., Lindon, J. C., Nicholson, J. K., Pognan, F., Lenz, E. M., & Wilson, I. D. (2004) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2003.12.019 · Cited by 164 · see citing works
Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training
Koziris, L. P., Hickson, R. C., Chatterton, R. T., Groseth, R. T., Christie, J. M., Goldflies, D. G., & Unterman, T. G. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.4.1436 · Cited by 157 · see citing works
“IGF-I also circulates bound to lower-molecular-weight IGFBPs, including IGFBP-1, a 30-kDa protein, which is produced largely in the liver and is thought to be the major short-term modulator of IGF-I bioavailability (23).”
Background
Diabetes and ethnic minorities
Oldroyd, J. C., Banerjee, M., Heald, A. H., & Cruickshank, K. J. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.029124 · Cited by 158 · see citing works
Hormonal, Metabolic, and Inflammatory Profiles and Endometrial Cancer Risk Within the EPIC Cohort—A Factor Analysis
Dossus, L., Lukanova, A., Rinaldi, S., Allen, N. E., Cust, A. E., Becker, S., Tjønneland, A. M., Hansen, L., Overvad, K., Chabbert‐Buffet, N., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws309 · Cited by 148 · see citing works
Implantation: Embryonic Signals and the Modulation of the Uterine Environment—A Review
Fazleabas, A. T., Kim, J., & Straková, Z. (2004) · Placenta · doi:10.1016/j.placenta.2004.01.014 · Cited by 145 · see citing works
“Its proposed roles in reproductive physiology and pathology are numerous ([46]; reviewed by Fowler et al.”
BackgroundInfluential
FKHR Binds the Insulin Response Element in the Insulin-Like Growth Factor Binding Protein-1 Promoter
Durham, S. K., Suwanichkul, A., Scheimann, A. O., Yee, D., Jackson, J. G., Barr, F. G., & Powell, D. R. (1999) · Endocrinology · doi:10.1210/endo.140.7.6856 · Cited by 147 · see citing works
“The ability of FKHR to stimulate production of IGFBP-1, a protein which blocks IGF-mediated growth and substrate utilization in vivo (1), is consistent with the ability of the FKHR homologue DAF-16 to slow growth and shift metabolism away from energy utilization in C.”
Background
Insulin-Like Growth Factor-I and Insulin Are Associated With the Presence and Advancement of Adenomatous Polyps
Schoen, R. E., Weissfeld, J. L., Kuller, L. H., Thaete, F. L., EVANS, R., Hayes, R. B., & Rosen, C. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.051 · Cited by 159 · see citing works
Regulation of Insulin-Like Growth Factor Binding Protein-1 during Protracted Critical Illness
Mesotten, D., Delhanty, P. J. D., Vanderhoydonc, F., Hardman, K. V., Weekers, F., Baxter, R. C., & den Berghe, G. V. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020664 · Cited by 140 · see citing works
“The two dominant metabolic influences on IGFBP-1 gene expression appear to be insulin, which is suppressive, and the availability of hepatic substrate, with IGFBP-1 stimulated by substrate deprivation (7).”
Background
High Plasma Resistin Level Is Associated with Enhanced Highly Sensitive C-Reactive Protein and Leukocytes
Kunnari, A., Ukkola, O. H., Päivänsalo, M. J., & Kesäniemi, Y. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2115 · Cited by 138 · see citing works
A Prospective Study on Circulating Insulin-Like Growth Factor I (IGF-I), IGF-Binding Proteins, and Cognitive Function in the Elderly
Kalmijn, S., Janssen, J. A. M. J. L., Pols, H. A. P., Lamberts, S. W. J., & Breteler, M. M. B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7033 · Cited by 140 · see citing works
Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth
Arslanian, S. A., Bacha, F., Saad, R., & Gungor, N. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.115 · Cited by 138 · see citing works
“There is convincing evidence that IGFBP-1 plays an integral role in glucoregulation (31).”
Background
Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury
Leu, J. I., Crissey, M. A. S., Leu, J. P., Ciliberto, G., & Taub, R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.2.414-424.2001 · Cited by 134 · see citing works
Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
Rajwani, A., Ezzat, V., Smith, J., Yuldasheva, N. Y., Duncan, E. R., Gage, M., Cubbon, R. M., Kahn, M., Imrie, H., Abbas, A., et al. (2012) · Diabetes · doi:10.2337/db11-0963 · Cited by 135 · see citing works
“Although the receptor for IGFBP1 (6) and the proximal signaling intermediaries are yet to be identified, IGFBP1stimulated NO production is also mediated through the PI3K/Akt pathway, culminating in phosphorylation of eNOS (7) and an increase in NOS activity.”
Background
IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty
Maggio, M. G., Vita, F. D., Lauretani, F., Buttò, V., Bondi, G., Cattabiani, C., Nouvenne, A., Meschi, T., Dall’Aglio, E., & Ceda, G. P. (2013) · Nutrients · doi:10.3390/nu5104184 · Cited by 135 · see citing works
“IGF-1 bioactivity and bioavailability are influenced by six binding proteins (IGFBPs), which also have independent biological actions [12].”
Background
The expression of the IGF system in the bovine uterus throughout the oestrous cycle and early pregnancy
Robinson, R. S., Mann, G. E., Gadd, T., et al. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650231 · Cited by 135 · see citing works
“Since high endometrial IGFBP-1 levels are observed when progesterone levels are high and the human IGFBP-1 gene contains a progesterone response element, it has been suggested that progesterone regulates IGFBP-1 expression in the endometrium (Lee et al. 1997, Tseng et al. 1997).”
Background
Prediction of Nephrotoxicant Action and Identification of Candidate Toxicity-Related Biomarkers
Thukral, S. K., Nordone, P. J., Hu, R., Sullivan, L., Galambos, E., Fitzpatrick, V. D., Healy, L. N., Bass, M. B., Cosenza, M. E., & Afshari, C. A. (2005) · Toxicologic Pathology · doi:10.1080/01926230590927230 · Cited by 132 · see citing works
“Additional genes associated with tissue remodeling included osteopontin, TIMP1, IGFBP1, all of which have been associated with kidney remodeling following acute renal failure (Eddy and Giachelli, 1995; Lee et al., 1997; Bohe et al., 1998; Persy et al., 1999; Huang et al., 2001).”
Background
Growth hormone/insulin-like growth factor system in children with chronic renal failure
T�nshoff, B., Kiepe, D., & Ciarmatori, S. (2005) · Pediatric Nephrology · doi:10.1007/s00467-005-1821-0 · Cited by 130 · see citing works
Transgenic mouse models for studying the functions of insulin‐like growth factor‐binding proteins
Schneider, M. R., Lahm, H., Wu, M., Hoeflich, A., & Wolf, E. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.629 · Cited by 128 · see citing works
“Likewise, IGFBP-1 is involved in intrauterine growth regulation in humans (49) and rodents (75, 76).”
Background
Effects of protein-rich supplementation and nandrolone in lean elderly women with femoral neck fractures
Tidermark, J., Ponzer, S., Carlsson, P., Söderqvist, A., Brismar, K., Tengstrand, B., & Cederholm, T. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2003.10.006 · Cited by 127 · see citing works
Structure, Developmental Expression, and Physiological Regulation of Zebrafish IGF Binding Protein-1
Maures, T. J., & Duan, C. (2002) · Endocrinology · doi:10.1210/endo.143.7.8905 · Cited by 128 · see citing works
Serum insulin-like growth factor binding proteins (IGFBPs) as markers for anabolic/catabolic condition in fishes
Kelley, K. M., Haigwood, J. T., Pérez, M. E. M., et al. (2001) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(01)00314-1 · Cited by 123 · see citing works
Acute Stress Response in Children with Meningococcal Sepsis: Important Differences in the Growth Hormone/Insulin-Like Growth Factor I Axis between Nonsurvivors and Survivors
de Groof, F., Joosten, K. F. M., Janssen, J. A. M. J. L., de Kleijn, E. D., Hazelzet, J. A., Hop, W. C. J., Uitterlinden, P., van Doorn, J., & Hokken‐Koelega, A. C. S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8605 · Cited by 122 · see citing works
“Normally, circulating IGFBP-1 is mainly regulated by insulin through inhibition of gene transcription in the liver, constituting a major determinant of free IGF-I availability (32, 33).”
Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription
Yeagley, D., Guo, S., Unterman, T. G., & Quinn, P. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101215200 · Cited by 117 · see citing works
Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans
Soop, M., Duxbury, H., Agwunobi, A. O., Gibson, M., Hopkins, S. J., Childs, C., Cooper, R. G., Maycock, P. F., Little, R. A., & Carlson, G. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00535.2001 · Cited by 118 · see citing works
The UV-absorber benzophenone-4 alters transcripts of genes involved in hormonal pathways in zebrafish (Danio rerio) eleuthero-embryos and adult males.
Zucchi, S., Blüthgen, N., Ieronimo, A., & Fent, K. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.10.001 · Cited by 121 · see citing works
“(2000) demonstrated that oral administration of estradiol increases circulating levels of IGFBP-1, and it is also up-regulatedduring catabolic states, such as insulin-dependent diabetes mellitus and after stress conditions in mammals and fish (Lee et al., 1997; Kelley et al., 2001).”
Background
Duplication and Diversification of the Hypoxia-Inducible IGFBP-1 Gene in Zebrafish
Kamei, H., Lu, L., Jiao, S., Li, Y., Gyrup, C., Laursen, L. S., Oxvig, C., Zhou, J., & Duan, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003091 · Cited by 114 · see citing works
“In the L-domain of mammalian IGFBP-1, there is a proline, glutamine, serine, and threonine (PEST) motif, known to contribute to its susceptibility to proteolysis [15].”
Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice
Leu, J. I.-J., Crissey, M. A. S., & Taub, R. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16712 · Cited by 128 · see citing works
Evolution of Ancient Functions in the Vertebrate Insulin-Like Growth Factor System Uncovered by Study of Duplicated Salmonid Fish Genomes
Macqueen, D. J., de la serrana, D. G., & Johnston, I. A. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst017 · Cited by 112 · see citing works
“…al. 2002, 2006; Ren et al. 2008), whereas IGFBP-1 and -2 generally inhibit the growth-promoting functions of IGF in both mammals and fish (Gockerman et al. 1995; Lee et al. 1997; Duan et al. 1999; Firth and Baxter 2002; Kiepe et al. 2002; Kajimura et al. 2005; Zhou et al. 2008; Kamei et al. 2008).”
HOX gene network is involved in the transcriptional regulation of in vivo human adipogenesis
Cantile, M., Procino, A., D'Armiento, M. R., Cindolo, L., & Cillo, C. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10210 · Cited by 111 · see citing works
The Complex Biology of FOXO
Monsalve, M., & Olmos, Y. (2011) · Current Drug Targets · doi:10.2174/138945011796150307 · Cited by 112 · see citing works
“differentiation both in vitro [298] and in vivo [299, 300] and is thought to play a role during blastocyst implantation [295].”
Background
Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression
Zhao, H.-L., Sui, Y., Qiao, C., Yip, K. Y.-L., Leung, R. K. K., Tsui, S. K., Lee, H.-M., Wong, H. K. T., Zhu, X., Siu, J. J., et al. (2012) · Diabetes · doi:10.2337/db11-1164 · Cited by 110 · see citing works
“The insulin/IGF-I/IGFBP pathway constitutes a complex network to modulate energy metabolism and cellular growth (31), in part mediated through the PI3K/Akt/mammalian target of rapamycin pathway (32–34).”
PCOS and Depression: Common Links and Potential Targets
Kolhe, J. V., Chhipa, A. S., Butani, S., Chavda, V. K., & Patel, S. S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00765-2 · Cited by 108 · see citing works
Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes
de la serrana, D. G., & Macqueen, D. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00080 · Cited by 108 · see citing works
Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation
Leu, J. I.-J., Crissey, M. A. S., Craig, L. E., & Taub, R. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1251-1259.2003 · Cited by 108 · see citing works
Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure
Frystyk, J., Ivarsen, P., Skjærbæk, C. B., et al. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00798.x · Cited by 108 · see citing works
Elevated Serum Levels of Free Insulin-Like Growth Factor I in Polycystic Ovary Syndrome1
van Dessel, H. J. H. M., Lee, P., Faessen, G. H., Fauser, B. C. J. M., & Giudice, L. C. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5941 · Cited by 108 · see citing works
Self-citation
Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice
Leu, J. I.-J., Crissey, M. A. S., & Taub, R. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316712 · Cited by 108 · see citing works
Developmental response to hypoxia
Huang, S.-T. J., Vo, K. C., Lyell, D. J., Faessen, G. H., Tulac, S., Tibshirani, R. J., Giaccia, A. J., & Giudice, L. C. (2004) · The FASEB Journal · doi:10.1096/fj.03-1377com · Cited by 104 · see citing works
“minute availability of free IGF-I in the circulation (6, 7).”
BackgroundSelf-citation
Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells1
Kim, J. J., Taylor, H. S., Akbas, G. E., Foucher, I., Trembleau, A., Jaffe, R. C., Fazleabas, A. T., & Unterman, T. G. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.009316 · Cited by 106 · see citing works
“Insulin-like growth factor binding protein-1 (IGFBP-1) is expressed primarily in the liver, kidney, decidualized endometrium, and luteinizing granulosa cells [1].”
Background
Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression
Kim, S. T., & Moley, K. H. (2008) · Reproduction · doi:10.1530/rep-08-0167 · Cited by 106 · see citing works
“Oxidation of lipids, proteins, and other macromolecules such as DNA occurs during the development of diabetes (Ohkawa et al. 1979), and mitochondrial DNA mutations have also been reported in diabetic tissues, suggesting oxidative stress-related mitochondrial damage (Lee et al. 1997).”
Background
The Role of Endocrine Insulin-Like Growth Factor-I and Insulin in Breast Cancer
Lann, D. E., & LeRoith, D. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9100-x · Cited by 104 · see citing works
“Hyperinsulinemia, the hallmark of type 2 diabetes, can lead to the repression of IGFBP-1 hepatic production and therefore decreased release into circulation [80, 81].”
Background
Serum levels of C‐peptide, IGFBP‐1 and IGFBP‐2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition
Cust, A. E., Allen, N. E., Rinaldi, S., Dossus, L., Friedenreich, C. M., Olsen, A., Tjønneland, A. M., Overvad, K., Clavel‐Chapelon, F., Boutron‐Ruault, M., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.22578 · Cited by 102 · see citing works
“Lower IGFBP-1 and IGFBP-2 levels may lead to increased IGF-I bioavailability in the circulation and endometrial tissue,(2,11,13,41,43) because contrary to IGFBP-3, IGFBP-1 and IGFBP-2 can combine with IGF-I to form a small complex that can cross the capillary endothelium and prevent IGF-I receptor binding.(11,12,14,40…”
BackgroundResult
Changes in the circulating IGF system during short-term fasting and refeeding in rats
Frystyk, J., Delhanty, P. J. D., Skjærbæk, C., et al. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e245 · Cited by 102 · see citing works
“In fact, because the liver is the primary source of circulating IGFBP-1, serum IGFBP-1 has been suggested to reflect portal rather than peripheral insulin levels (3, 15).”
BackgroundInfluential
Comparative Biology of the IGF System in Endometrium, Decidua, and Placenta, and Clinical Implications for Foetal Growth and Implantation Disorders
Nayak, N. R., & Giudice, L. C. (2003) · Placenta · doi:10.1053/plac.2002.0906 · Cited by 101 · see citing works
Self-citation
Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects
Colao, A., Somma, C. D., Cascella, T., Pivonello, R., Vitale, G., Grasso, L. F. S., Lombardi, G., & Savastano, S. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0201 · Cited by 101 · see citing works
Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondriaPreprint
Leu, J. I.-J., & George, D. L. (2007) · Genes & Development · doi:10.1101/gad.1567107 · Cited by 100 · see citing works
“However, many recent studies have documented that these IGFBP proteins also have important intracellular functions that are independent of, and unrelated to, their secretion and interactions with the IGFs (Lee et al. 1997; Duan and Xu 2005).”
BackgroundInfluential
Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid
Perluigi, M., di Domenico, F., Fiorini, A., Cocciolo, A., Giorgi, A., Foppoli, C., Butterfield, D. A., Giorlandino, M., Giorlandino, C., Eugenia Schininà, M., et al. (2011) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201000121 · Cited by 97 · see citing works
“IGFBP-1 regulates minute-to-minute bioavailability of IGFs in the circulation and inhibits IGF actions [50].”
Background
Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual–trophoblast interface
Giudice, L. C., Mark, S., & Irwin, J. C. (1998) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(98)00018-7 · Cited by 97 · see citing works
Self-citation
Circulating insulin-like growth factor binding proteins in fish: Their identities and physiological regulation
Shimizu, M., & Dickhoff, W. W. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.08.002 · Cited by 95 · see citing works
“Circulating levels of IGFBP-1 are generally inversely related to those of insulin after meals, and insulin treatment inhibits IGFBP-1 both at the mRNA and protein levels (Lee et al., 1993, 1997).”
Background
The role of IGF‐I and its binding proteins in the development of type 2 diabetes and cardiovascular disease
Ezzat, V., Duncan, E. R., Wheatcroft, S. B., & Kearney, M. T. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00709.x · Cited by 91 · see citing works
Effects of fasting on circulating IGF-binding proteins, glucose, and cortisol in channel catfish (Ictalurus punctatus)
Peterson, B. C., & Small, B. C. (2003) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2003.10.005 · Cited by 93 · see citing works
“IGFBP-1 has been shown to inhibit IGF actions in numerous in vitro and in vivo animal studies [34].”
BackgroundInfluential
Influence of Nutrition on Responses to Resistance Training
VOLEK, J. S. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000121944.19275.c4 · Cited by 93 · see citing works
“may contribute to glucose regulation by countering the insulin-like, hypoglycemic effects of free IGF-I (40).”
Background
Cribra orbitalia in two temporally disjunct population samples from the Dakhleh Oasis, Egypt
Fairgrieve, S. I., & Molto, J. E. (2000) · American Journal of Physical Anthropology · doi:10.1002/(sici)1096-8644(200003)111:3 · Cited by 89 · see citing works
Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
Larsson, S. C., Spyrou, N., & Mantzoros, C. S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155326 · Cited by 89 · see citing works
Effects of exogenous cortisol on the GH/IGF-I/IGFBP network in channel catfish
Peterson, B. C., & Small, B. C. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.01.003 · Cited by 91 · see citing works
“In addition, the IGFBP-1 gene possesses glucocorticoid-response elements, and the steroid can potentially increase IGFBP-1 levels [50].”
Epidemiology of Endometrial Carcinoma: Etiologic Importance of Hormonal and Metabolic Influences
Felix, A. S., Yang, H., Bell, D. W., & Sherman, M. E. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-43139-0_1 · Cited by 90 · see citing works
Effects of Weight Control and Physical Activity in Cancer Prevention
Kaaks, R., & Lukanova, A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04118.x · Cited by 89 · see citing works
Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis.
Ngo, T. H., Barnard, R. J., Cohen, P., et al. (2003) · PubMed · Cited by 90 · see citing works
IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training
Mero, A. A., Kähkönen, J., Nykänen, T., Parviainen, T., Jokinen, I. E., Takala, T., Nikula, T. K., Rasi, S., & Leppäluoto, J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00002.2002 · Cited by 88 · see citing works
Postprandial changes in plasma growth hormone, insulin, insulin-like growth factor (IGF)-I, and IGF-binding proteins in coho salmon fasted for varying periods
Shimizu, M., Cooper, K. A., Dickhoff, W. W., et al. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90939.2008 · Cited by 88 · see citing works
“The levels of free IGF-I are presumably regulated in part by short-term changes in IGFBP-1 (13, 22).”
BackgroundInfluential
The influence of fasting and energy restricting diets on IGF-1 levels in humans: A systematic review and meta-analysis
Rahmani, J., Kord‐Varkaneh, H., Clark, C. C. T., Zand, H., Bawadi, H. A., Ryan, P. M., Fatahi, S., & Zhang, Y. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100910 · Cited by 89 · see citing works

HORMONE ONTOGENY IN THE OVINE FETUS: XXI. THE EFFECT OF INSULIN-LIKE GROWTH FACTOR-I ON PLASMA FETAL GROWTH HORMONE, INSULIN AND GLUCOSE CONCENTRATIONS
de Zegher, F., Bettendorf, M., KAPLAN, S. L., et al. (1988) · Endocrinology · doi:10.1210/endo-123-1-658 · Cited by 33 · see citing works
Insulin-like Growth Factor I and Insulin and Their Abuse in Sport
Erotokritou‐Mulligan, I., & Holt, R. I. G. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.10.003 · Cited by 10 · see citing works
PO4-3: Serum levels of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) in women with cervical cancer
Cho, D. H., & Kim, M. S. (2014) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(14)50137-2
Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 Regulate the Expression of Insulin-Like Growth Factor-Binding Protein-3, -4, and -5 in Large Vessel Endothelial Cells*
Dahlfors, G., & Arnqvist, H. J. (2000) · Endocrinology · doi:10.1210/endo.141.6.7481 · Cited by 37 · see citing works
Stimulation of Bone Matrix Appositionin Vitroby Local Growth Factors: A Comparison between Insulin-like Growth Factor I, Platelet-Derived Growth Factor, and Transforming Growth Factor β*
PFEILSCHIFTE, J., OECHSNER, M., Naumann, A., et al. (1990) · Endocrinology · doi:10.1210/endo-127-1-69 · Cited by 210 · see citing works

Authors: Lee, P. D. K., Giudice, L. C., Conover, C. A., & Powell, D. R.
Affiliations: Mayo Clinic (US)
ORCID: Lee, P. D. K.
Giudice, L. C.
Conover, C. A.
Powell, D. R.
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 1997-12-01
Volume: 216
Issue: 3
Pages: 319-357
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.3181/00379727-216-44182
OpenAlex: W2036466897
Cited by: 523
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 10 · 2017: 19 · 2016: 16 · 2015: 16 · 2014: 11 · 2013: 17 · 2012: 14
FWCI: 16.84
Type: journal article
Language: en
Open access: closed
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: IGFBP-1, insulin-like growth factor, IGF binding, cysteine-rich region, protease cleavage, integrin binding, phosphorylation sites, IGFBP-3, chromosome 7, glucose metabolism, glucocorticoids, cyclic AMP, tissue-specific gene expression
MeSH terms: Amino Acid Sequence, Animals, Bone and Bones, Cartilage, Connective Tissue, Female, Gene Expression Regulation, Genitalia, Female, Genitalia, Male, Humans, Kidney, Liver, Male, Molecular Sequence Data, Organ Specificity, Substrate Specificity, Insulin-Like Growth Factor Binding Protein 1, Evolution, Molecular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks