Viral load of human papillomavirus and risk of CIN3 or cervical cancer
Abstract
Carcinogenic human papillomaviruses (HPV) are thought to be necessary for development of cervical cancer. We assessed whether higher viral loads of such viruses predicted future risk of CIN3 or cancer (CIN3+) in a cohort of 20810 women followed up for 10 years with cytological screening. We measured the viral load for 13 types of carcinogenic HPV (relative light units normalised to 1 pg/mL HPV 16 positive controls [RLU/PC]) using Hybrid Capture 2 testing of cervicovaginal lavages obtained at enrolment. Results were stratified into four groups (RLU/PC 1 to or = 1000). Although presence of HPV strongly increased risk of CIN3+, high viral load did not further predict risk of CIN3+.
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Other studies have not found a correlation between increased HR-HPV viral load and the severity and progression of cervical lesions.
“while others have not found such a correlation [15,16].”
From Comparative evaluation of Allplex HPV28 and Anyplex II HPV28 assays for high-risk HPV genotyping in cervical samples (2025) · cites this paper as [15]
The prognostic significance of HR-HPV viral load in cervical cancer remains controversial.
“The prognostic significance of HR-HPV viral load in cervical cancer remains controversial.”
From Comparative evaluation of Allplex HPV28 and Anyplex II HPV28 assays for high-risk HPV genotyping in cervical samples (2025) · cites this paper as [15]
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Mafi, S., Theuillon, F., Meyer, S., Woillard, J.-B., Dupont, M., Rogez, S., Alain, S., & Hantz, S. (2025) · PLOS ONE · doi:10.1371/journal.pone.0320978 · Cited by 9 · see citing works
- Authors
- Lorincz, A. T., Castle, P. E., Sherman, M. E., Scott, D. R., Glass, A. G., Wacholder, S., Rush, B. B., Gravitt, P. E., Schussler, J. E., & Schiffman, M.
- Affiliations
- National Institutes of Health (US)
- National Cancer Institute (US)
- Kaiser Permanente (US)
- Johns Hopkins University (US)
- Information Management Services (US)
- Corresponding author
- Lorincz, Attila T
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 360
- Issue
- 9328
- Pages
- 228-229
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1984833080
- Cited by
- 260
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 10 · 2012: 12
- FWCI
- 18.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- human papillomavirus, viral load, cervical intraepithelial neoplasia grade 3, cervical cancer, Hybrid Capture 2, cervicovaginal lavage, HPV16, cervical cancer risk prediction, cytology screening
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Female, Follow-Up Studies, Humans, Middle Aged, Risk Factors, Vaginal Smears, Cohort Studies, Viral Load, Papillomaviridae, Papillomavirus Infections
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