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Cited by 691

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Influenza

Open access
Nicholson, Karl G, Wood, John M, Zambon, Maria·2003·The Lancet

Abstract

Summary Although most influenza infections are self-limited, few other diseases exert such a huge toll of suffering and economic loss. Despite the importance of influenza, there had been, until recently, little advance in its control since amantadine was licensed almost 40 years ago. During the past decade, evidence has accrued on the protection afforded by inactivated vaccines and the safety and efficacy in children of live influenza-virus vaccines. There have been many new developments in vaccine technology. Moreover, work on viral neuraminidase has led to the licensing of potent selective antiviral drugs, and economic decision modelling provides further justification for annual vaccination and a framework for the use of neuraminidase inhibitors. Progress has also been made on developing near-patient testing for influenza that may assist individual diagnosis or the recognition of widespread virus circulation, and so optimise clinical management. Despite these advances, the occurrence of avian H5N1, H9N2, and H7N7 influenza in human beings and the rapid global spread of severe acute respiratory syndrome are reminders of our vulnerability to an emerging pandemic. The contrast between recent cases of H5N1 infection, associated with high mortality, and the typically mild, self-limiting nature of human infections with avian H7N7 and H9N2 influenza shows the gaps in our understanding of molecular correlates of pathogenicity and underlines the need for continuing international research into pandemic influenza. Improvements in animal and human surveillance, new approaches to vaccination, and increasing use of vaccines and antiviral drugs to combat annual influenza outbreaks are essential to reduce the global toll of pandemic and interpandemic influenza.

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Crossref · 10.1016/s0140-6736(03)14854-4

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Metadata

Authors
Nicholson, K. G., Wood, J. M., & Zambon, M.
Venue
The Lancet
Publisher
Elsevier BV
Published
2003-11
Volume
362
Issue
9397
Pages
1733-1745
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W4205978945
Cited by
691
References
11
FWCI
22.87
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Influenza. https://app.cochat.ai/papers/10.1016/s0140-6736(03)14854-4
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Nicholson, K. G., Wood, J. M., & Zambon, M. (2003). Influenza. The Lancet. https://doi.org/10.1016/s0140-6736(03)14854-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.