Thyroxine adherence in primary hypothyroidism
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Patients may sometimes miss a dose or ingest LT4 with breakfast for convenience, which is observed in 30% to 70% of patients.
“Patients may sometimes miss a dose or ingest LT4 with breakfast for convenience, which is observed in 30% to 70% of patients (9, 10).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [9]
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Cites
Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence
Morisky, D. E., Green, L. W., & Levine, D. M. (1986) · Medical Care · doi:10.1097/00005650-198601000-00007 · Cited by 5,304 · see citing works
Roberts, C. G., & Ladenson, P. W. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15696-1 · Cited by 567 · see citing works
Is This Patient Taking the Treatment as Prescribed?
Stephenson, B. (1993) · JAMA · doi:10.1001/jama.269.21.2779 · Cited by 381 · see citing works
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
“One survey of patients prescribed LT4 found a self-reported nonadherence rate of 22% (325).”
Treatment with thyroid hormone
Biondi, B., & Wartofsky, L. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1083 · Cited by 259 · see citing works
Optimal thyroid hormone replacement
Jonklaas, J. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab031 · Cited by 89 · see citing works
When thyroid hormone replacement is ineffective?
Benvenga, S. (2013) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000003 · Cited by 74 · see citing works
Thyroxine replacement: a clinical endocrinologist’s viewpoint
Eligar, V, Taylor, P., Okosieme, O., Leese, G., & Dayan, C. (2016) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563216642255 · Cited by 72 · see citing works
Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63 · see citing works
Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis
Hepp, Z., Wyne, K. L., Manthena, S. R., Wang, S., & Gossain, V. V. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1486293 · Cited by 48 · see citing works
Thyroid hormone replacement: current status and challenges
Okosieme, O. E. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.600307 · Cited by 33 · see citing works
Thyroid Hormone Replacement in Patients Following Thyroidectomy for Thyroid Cancer
Hannoush, Z. C., & Weiss, R. E. (2016) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10229 · Cited by 27 · see citing works
Mols, F., Thong, M. S. Y., Denollet, J., Oranje, W. A., Netea-Maier, R. T., Smit, J. W. A., & Husson, O. (2019) · Psychology and Health · doi:10.1080/08870446.2019.1619730 · Cited by 20 · see citing works
Dew, R., King, K., Okosieme, O. E., Pearce, S. H. S., Donovan, G., Taylor, P. N., Leese, G., Hickey, J., Razvi, S., Dayan, C. M., et al. (2017) · BJGP Open · doi:10.3399/bjgpopen17x100977 · Cited by 16 · see citing works
EMPATHY: A New Tool for Identifying the Most Suitable Thyroxine Formulation in Hypothyroid Patients
Bellastella, G., Caputo, M., Maiorino, M. I., Longo, M., Scappaticcio, L., Giugliano, D., & Esposito, K. (2019) · Thyroid · doi:10.1089/thy.2018.0493 · Cited by 14 · see citing works
Gottwald‐Hostalek, U., & Razvi, S. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2071059 · Cited by 10 · see citing works
Elsherbiny, T. M. (2021) · Dubai Diabetes and Endocrinology Journal · doi:10.1159/000513927 · Cited by 6 · see citing works
Razvi, S. (2026) · Current Medical Research and Opinion · doi:10.1080/03007995.2026.2740285
- Authors
- Crilly, M.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Crilly, Mike
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 363
- Issue
- 9420
- Pages
- 1558
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2037433179
- Cited by
- 16
- References
- 3
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- primary hypothyroidism, medication non-adherence, self-reported adherence, primary care management, levothyroxine, patient-centered care
- MeSH terms
- Humans, Hypothyroidism, Patient Compliance, Thyroxine
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