S100A8 and S100A9 in inflammatory diseases
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The significant up-regulation of S100A8 and LYZ suggests an enhanced inflammatory response in AD monocytes.
“Given their major roles in the immune response and inflammation (54, 55), the significant up-regulation of S100A8 and LYZ suggested an enhanced inflammatory response in AD monocytes.”
From Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems (2025) · cites this paper as [54]
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“Given their major roles in the immune response and inflammation ( 54 , 55 ), the significant up-regulation of S100A8 and LYZ suggested an enhanced inflammatory response in AD monocytes.”
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- Authors
- Roth, J., Goebeler, M., & Sorg, C.
- Affiliations
- University of Münster (DE)
- Corresponding author
- Roth, J
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 357
- Issue
- 9261
- Pages
- 1041
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2121105894
- Cited by
- 66
- References
- 5
- Citations by year
- 2025: 5 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- calprotectin, S-100 protein, calcium-binding proteins, fecal biomarkers, gastrointestinal diseases, inflammatory diseases, protein molecular weight, antimicrobial activity, chemotaxis, cytotoxicity, intracellular signaling, S100A12, S100A16
- MeSH terms
- Antigens, Differentiation, Calcium-Binding Proteins, Feces, Humans, Inflammation, Membrane Glycoproteins, S100 Proteins, Neural Cell Adhesion Molecules, Leukocyte L1 Antigen Complex, Calgranulin A, Calgranulin B
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