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Cited by 850Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesDiet and metabolism studies

The DOI matches its Crossref record; 317 of the 321 references it cites were found in a registry or an index.

Epilepsy in children

Guerrini, Renzo·2006·The Lancet
DOI 10.1016/s0140-6736(06)68182-8
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Abstract

10.5 million children worldwide are estimated to have active epilepsy. Over the past 15 years, syndrome-oriented clinical and EEG diagnosis, and better aetiological diagnosis, especially supported by neuroimaging, has helped to clarify the diversity of epilepsy in children, and has improved management. Perinatal and postinfective encephalopathy, cortical dysplasia, and hippocampal sclerosis account for the most severe symptomatic epilepsies. Ion channel defects can underlie both benign age-related disorders and severe epileptic encephalopathies with a progressive disturbance in cerebral function. However, the reasons for age-related expression in children are not understood. Neither are the mechanisms whereby an epileptic encephalopathy originates. Several new drugs have been recently introduced but have provided limited therapeutic benefits. However, treatment and quality of life have improved because the syndrome-specific efficacy profile of drugs is better known, and there is heightened awareness that compounds with severe cognitive side-effects and heavy polytherapies should be avoided. Epilepsy surgery is an important option for a few well-selected individuals, but should be considered with great caution when there is no apparent underlying brain lesion.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(06)68182-8

Cites

317 of 317 references verified0 citation errors · 0 not checkable

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Citations

Cites

2 retracted

Show all 321 references

Research works printed but not linked: 1

  1. Erba, 1990, Sturge-Weber syndrome: Natural history and indications for surgery, J Epilepsy, 3, 287

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Related

Metadata

Authors
Guerrini, R.
Affiliations
University of Pisa (IT)
Corresponding author
Guerrini, Renzo
ORCID
Guerrini, Renzo
Venue
The Lancet
Publisher
Elsevier BV
Published
2006-02
Volume
367
Issue
9509
Pages
499-524
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(06)68182-8
OpenAlex
W2047243927
Cited by
848
References
321
Citations by year
2026: 15 · 2025: 29 · 2024: 30 · 2023: 27 · 2022: 33 · 2021: 33 · 2020: 21 · 2019: 22 · 2018: 19 · 2017: 20 · 2016: 17 · 2015: 28 · 2014: 26 · 2013: 31 · 2012: 33
FWCI
4.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Keywords
pediatric epilepsy, epileptic encephalopathy, perinatal encephalopathy, cortical dysplasia, hippocampal sclerosis, ion channel disorders, benign rolandic epilepsy, antiepileptic drugs, epilepsy surgery, etiology, neuroimaging, EEG diagnosis, cognitive side effects
MeSH terms
Adolescent, Anticonvulsants, Child, Child, Preschool, Epilepsy, Humans, Infant, Infant, Newborn, Prognosis

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