The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
Open accessAbstract
Background Preliminary evidence is equivocal regarding the role of exhaled nitric oxide in clinical asthma management. This study evaluates the usefulness of eNO as an adjunct to asthma guidelines-based clinical care among inner-city adolescents and young adults. Methods A randomized, double-blind, parallel-group trial was conducted with 546 inner-city participants, aged 12–20 years, with persistent asthma (Clinicaltrials.gov Identifier: NCT00114413). A run-in characterization period of 3 weeks on an initial controller regimen preceded a 46-week double-blind treatment strategy. Participants were randomized to either, treatment based on NAEPP guidelines alone (Reference Group) or the guidelines plus FENO measurements (FENO Group). Primary outcome was asthma symptom days and secondary outcome was acute asthma exacerbations. Findings During the 46-week treatment period, the number of asthma symptom days, pulmonary function, unscheduled care visits, and hospitalizations did not differ between the treatment groups (mean asthma symptom days were 1.93 [95% CI 1.74-2.11] in the FENO group vs. 1.89 [1.71-1.74] in the control group; difference 0.04 [-0.29-0.22], p=0.7796). The FENO Group received a significantly higher inhaled corticosteroid dose (118.9 mcg/day difference, 95% CI: 48.5-189.3, P=0.0010) as compared to the Reference Group. Asthma symptoms remained low in both groups following randomization with 57% (306/534) of the participants well controlled for at least 80% of visits.. Interpretation A coordinated asthma management program facilitated achieving good control in the majority of participants. The addition of FENO as a control indicator resulted in a higher dose of inhaled corticosteroids without a clinically important improvement in symptomatic asthma control.
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Development of the asthma control test
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Self-citation(2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.029 · Cited by 2,181
Statistics in Medicine — Reporting of Subgroup Analyses in Clinical Trials
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Self-citationResults of a home-based environmental intervention among urban children with asthma
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Self-citationFeatures of severe asthma in school-age children: Atopy and increased exhaled nitric oxide
Fitzpatrick, A. M., Gaston, B. M., Erzurum, S. C., & Teague, W. G. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.08.019 · Cited by 197
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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Dweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918
Self-citationCloutier, M. M., Baptist, A. P., Blake, K. V., Brooks, E. G., Bryant-Stephens, T., DiMango, E., Dixon, A. E., Elward, K. S., Hartert, T., Krishnan, J. A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.003 · Cited by 854
Self-citationTeach, S. J., Gill, M. A., Togias, A., Sorkness, C. A., Arbes, S. J., Calatroni, A., Wildfire, J. J., Gergen, P. J., Cohen, R. T., Pongracic, J. A., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.09.008 · Cited by 537
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Metadata
- Authors
- Szefler, S. J., Mitchell, H., Sorkness, C. A., Gergen, P. J., O'Connor, G. T., Morgan, W. J., Kattan, M., Pongracic, J. A., Teach, S. J., Bloomberg, G. R., Eggleston, P. A., Gruchalla, R. S., Kercsmar, C. M., Liu, A. H., Wildfire, J. J., Curry, M. D., & Busse, W. W.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 372
- Issue
- 9643
- Pages
- 1065-1072
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2149411747
- Cited by
- 458
- References
- 7
- FWCI
- 33.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Szefler, S. J., Mitchell, H., Sorkness, C. A., Gergen, P. J., O'Connor, G. T., Morgan, W. J., Kattan, M., Pongracic, J. A., Teach, S. J., Bloomberg, G. R., Eggleston, P. A., Gruchalla, R. S., Kercsmar, C. M., Liu, A. H., Wildfire, J. J., Curry, M. D., & Busse, W. W. (2008). Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. The Lancet. https://doi.org/10.1016/s0140-6736(08)61448-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
