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Obsessive-compulsive disorder
Abstract
Obsessive—compulsive disorder is a common psychiatric disorder characterized by intrusive thoughts or ‘obsessions’, which predispose to repetitive acts or rituals, known as ‘compulsions’. These compulsions are necessary to relieve the anxiety caused by the obsession. Patients have insight into the unnecessary nature of the symptoms but can find them hard to suppress. Inability to carry out everyday activities can lead to significant functional impairment. Many feel embarrassed and go to great lengths to conceal the disorder from others which can lead to a delay in diagnosis and management.
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“Obsessive‐compulsive disorder (OCD) is a psychiatric disorder that is characterized by recurrent unwanted thoughts, anxiety and compulsive behavior, but is also often associated with cognitive deficits.1, 2, 3, 4, 5”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [1]
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Metadata
- Authors
- Abramowitz, J. S., Taylor, S., & McKay, D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of British Columbia (CA)
- Fordham University (US)
- Corresponding author
- Abramowitz, Jonathan S
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 374
- Issue
- 9688
- Pages
- 491-499
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2915979496
- Semantic Scholar
- 809a240033e7ca5ce0dc968592e31b6d6afb8816
- Cited by
- 1,002
- References
- 95
- Citations by year
- 2026: 38 · 2025: 38 · 2024: 39 · 2023: 38 · 2022: 35 · 2021: 38 · 2020: 59 · 2019: 54 · 2018: 47 · 2017: 49 · 2016: 54 · 2015: 75 · 2014: 77 · 2013: 74 · 2012: 71
- FWCI
- 81.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, anxiety disorders, obsessive-compulsive and related disorders, serotonin pathway, dorsolateral prefrontal cortex, cognitive-behavioral model, dysfunctional attitudes, serotonin reuptake inhibitors, cognitive behavioral therapy, D-cycloserine
- MeSH terms
- Humans, Models, Biological, Obsessive-Compulsive Disorder
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