The DOI matches its Crossref record; 298 of the 300 references it cites were found in a registry or an index.
Human African trypanosomiasis
Abstract
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.
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“inflammatory markers appear to be independent predictors of mortality risk in older populations”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [78]
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Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,192
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The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“In human African trypanosomiasis (HAT), a parasitic disease also known as sleeping sickness, circadian sleep-wake disruption is characteristic, with sleep and wake periods distributed throughout the 24-h day (77, 83).”
BackgroundBüscher, P., Cecchi, G., Jamonneau, V., & Priotto, G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31510-6 · Cited by 711
Kinetoplastids: related protozoan pathogens, different diseases
Stuart, K., Brun, R., Croft, S. L., Fairlamb, A. H., Gürtler, R. E., McKerrow, J., Reed, S., & Tarleton, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33945 · Cited by 618
Self-citation
Metadata
- Authors
- Brun, R., Blum, J., Chappuis, F., & Burri, C.
- Affiliations
- Swiss Tropical and Public Health Institute (CH)
- Corresponding author
- Brun, Reto
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 375
- Issue
- 9709
- Pages
- 148-159
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2151877638
- Cited by
- 926
- References
- 300
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 35 · 2023: 40 · 2022: 35 · 2021: 47 · 2020: 39 · 2019: 50 · 2018: 49 · 2017: 69 · 2016: 71 · 2015: 78 · 2014: 74 · 2013: 85 · 2012: 85
- FWCI
- 45.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Medecins Sans Frontieres Field Research (Medecins Sans Frontieres) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- sleeping sickness, Trypanosoma brucei gambiense, tsetse flies, neglected tropical diseases, disease resurgence, political instability, vector control, disease elimination, clinical features, diagnosis, treatment, adverse drug reactions, sub-Saharan Africa
- MeSH terms
- Africa, Eflornithine, Animals, Communicable Disease Control, Humans, Insect Bites and Stings, Insect Vectors, Melarsoprol, Pentamidine, Suramin, Trypanocidal Agents, Trypanosoma brucei gambiense, Trypanosomiasis, African, Tsetse Flies, Variant Surface Glycoproteins, Trypanosoma, Incidence, Endemic Diseases, Biomedical Research
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