Cited by 941Trypanosoma species research and implicationsResearch on Leishmaniasis StudiesVector-borne infectious diseases

The DOI matches its Crossref record; 298 of the 300 references it cites were found in a registry or an index.

Human African trypanosomiasis

Brun, Reto, Blum, Johannes, Chappuis, Francois, Burri, Christian·2010·The Lancet

DOI 10.1016/s0140-6736(09)60829-1

Open this paper in CoChat — free account

Abstract

Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(09)60829-1

Cites

298 of 298 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Polyamine metabolism and function
Pegg, A. E., & McCann, P. P. (1982) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1982.243.5.c212 · Cited by 1,661
The Genome of the African Trypanosome Trypanosoma brucei
Berriman, M., Ghedin, E., Hertz‐Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E. V., Hamlin, N. E., Haas, B. J., et al. (2005) · Science · doi:10.1126/science.1112642 · Cited by 1,634
Manson's Tropical Diseases.
(1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-2-324_1 · Cited by 997
Comparative Genomics of Trypanosomatid Parasitic Protozoa
El-Sayed, N. M., Myler, P. J., Blandin, G., Berriman, M., Crabtree, J., Aggarwal, G., Caler, E. V., Renauld, H., Worthey, E. A., Hertz‐Fowler, C., et al. (2005) · Science · doi:10.1126/science.1112181 · Cited by 832
Kinetoplastids: related protozoan pathogens, different diseases
Stuart, K., Brun, R., Croft, S. L., Fairlamb, A. H., Gürtler, R. E., McKerrow, J., Reed, S., & Tarleton, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33945 · Cited by 618
Self-citation
A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences.
Tibayrenc, M., Kjellberg, F., & Ayala, F. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2414 · Cited by 570
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
Priotto, G., Kasparian, S., Mutombo, W., Ngouama, D., Ghorashian, S., Arnold, U., Ghabri, S., Baudin, E., Buard, V., Kazadi-Kyanza, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61117-x · Cited by 544
HOME OR AWAY?
Jb, B., & Gj, R. (1964) · PubMed · Cited by 507
Medical Insects and Arachnids
Lane, R. P., & Crosskey, R. W. (1993) · Springer eBooks · doi:10.1007/978-94-011-1554-4 · Cited by 488
Glossina austeni (Diptera: Glossinidae) Eradicated on the Island of Unguja, Zanzibar, Using the Sterile Insect Technique
Vreysen, M. J. B., Saleh, K. M., Ali, M. Y., Abdulla, A. M., Zhu, Z.-R., Juma, K. G., Dyck, V. A., Msangi, A. R., Mkonyi, P. A., & Feldmann, H. U. (2000) · Journal of Economic Entomology · doi:10.1603/0022-0493-93.1.123 · Cited by 477

Show all 300 references

Research works printed but not linked: 4

Bronner U. Pharmacokinetics of pentamidine. Focus on treatment of Trypanosoma gambiense sleeping sickness. PhD thesis, Karolinska Institute, 1994.
Seixas J. Investigations on the encephalopathic syndrome during melarsoprol treatment of human African trypanosomiasis. PhD thesis, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 2004.
Chappuis, 2004, Eflornithine for the treatment of human African trypanosomiasis: practical perspectives, Dev Sante, 171, 41
African Union. Statement from the Commission of the African union to the AHP/DFID special workshop on: tsetse control—the next 100 years, Sept 9–10, 2002, Edinburgh, UK.

Sorted by citations

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Kyu, H. H., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32335-3 · Cited by 4,192
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
Hay, S. I., Abajobir, A. A., Abate, K. H., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abdulkader, R. S., Abdulle, A. M., Abebo, T. A., Abera, S. F., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32130-x · Cited by 2,083
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“In human African trypanosomiasis (HAT), a parasitic disease also known as sleeping sickness, circadian sleep-wake disruption is characteristic, with sleep and wake periods distributed throughout the 24-h day (77, 83).”
Background
Human African trypanosomiasis
Büscher, P., Cecchi, G., Jamonneau, V., & Priotto, G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31510-6 · Cited by 711
Kinetoplastids: related protozoan pathogens, different diseases
Stuart, K., Brun, R., Croft, S. L., Fairlamb, A. H., Gürtler, R. E., McKerrow, J., Reed, S., & Tarleton, R. L. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33945 · Cited by 618
Self-citation
Management of suspected viral encephalitis in adults – Association of British Neurologists and British Infection Association National Guidelines
Solomon, T., Michael, B. D., Smith, P. E., Sanderson, F., Davies, N. W. S., Hart, I. J., Holland, M., Easton, A., Buckley, C. J., Kneen, R., et al. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.11.014 · Cited by 474
Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)
Kennedy, P. G. E. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70296-x · Cited by 438
Epidemiology of human African trypanosomiasis
Simarro, P. P., Franco, J., Diarra, A., & Jannin, J. G. (2014) · Clinical Epidemiology · doi:10.2147/clep.s39728 · Cited by 413
Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications
Periferakis, A., Periferakis, K., Bădărău, I. A., Petran, M. E., Popa, D. C., Căruntu, A., Costache, R. S., Scheau, C., Căruntu, C., & Costache, D. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315054 · Cited by 385
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
Nagle, A. S., Khare, S., Kumar, A. B., Supek, F., Buchynskyy, A., Mathison, C. J. N., Chennamaneni, N. K., Pendem, N., C, F. S. B. A., Gelb, M. H., et al. (2014) · Chemical Reviews · doi:10.1021/cr500365f · Cited by 352
Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness
Torreele, E., Trunz, B. B., Tweats, D. J., Kaiser, M., Brun, R., Mazué, G., Bray, M. A., & Pécoul, B. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000923 · Cited by 336
Self-citation
Management of trypanosomiasis and leishmaniasis
Barrett, M. P., & Croft, S. L. (2012) · British Medical Bulletin · doi:10.1093/bmb/lds031 · Cited by 307
Neglected tropical diseases: diagnosis, clinical management, treatment and control
Utzinger, J., Becker, S. L., Knopp, S., Blum, J. A., Neumayr, A. L. C., Keiser, J., & Hatz, C. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13727 · Cited by 270
Self-citation
Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites
Hall, B. S., Bot, C., & Wilkinson, S. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.230847 · Cited by 259
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part I
Schmidt, T. J., Khalid, S. A., Romanha, Á. J., Alves, T. M., Biavatti, M. W., Brun, R., Costa, F. B. D., de Castro, S. L., Ferreira, V. F., Lacerda, M., et al. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800229023 · Cited by 265
Self-citation
Emerging and Reemerging Neglected Tropical Diseases: a Review of Key Characteristics, Risk Factors, and the Policy and Innovation Environment
Mackey, T. K., Liang, B. A., Cuomo, R. E., Hafen, R., Brouwer, K. C., & Lee, D. E. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00045-14 · Cited by 259
A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis
Babokhov, P., Sanyaolu, A. O., Oyibo, W. A., Fagbenro-Beyioku, A. F., & Iriemenam, N. C. (2013) · Pathogens and Global Health · doi:10.1179/2047773213y.0000000105 · Cited by 234
Extracellular vesicles in parasitic diseases
Marcilla, A., Jaular, L. M., Trelis, M., Menezes‐Neto, A., Osuna, A., Bernal, D., Fernández-Becerra, C., de Almeida, I. C., & Portillo, H. A. D. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.25040 · Cited by 237
The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases
Cheuka, P. M., Mayoka, G. W., Mutai, P., & Chibale, K. (2016) · Molecules · doi:10.3390/molecules22010058 · Cited by 235
APOL1 Kidney Risk Alleles: Population Genetics and Disease Associations
Limou, S., Nelson, G. W., Kopp, J. B., & Winkler, C. A. (2014) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2014.06.005 · Cited by 221
Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure
Glišić, B. Đ., & Djuran, M. I. (2014) · Dalton Transactions · doi:10.1039/c4dt00022f · Cited by 218
Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal
Jamonneau, V., Ilboudo, H., Kaboré, J., Kaba, D., Koffi, M., Solano, P., Garcia, A., Courtin, D., Laveissière, C., Kouakou, L., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001691 · Cited by 204
The elimination of human African trypanosomiasis: Achievements in relation to WHO road map targets for 2020
Franco, J. R., Cecchi, G., Paone, M., Diarra, A., Grout, L., Ebeja, A. K., Simarro, P. P., Zhao, W., & Argaw, D. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010047 · Cited by 189
Inhibitory Activity of Marine Sponge-Derived Natural Products against Parasitic Protozoa
Orhan, İ. E., Şener, B., Kaiser, M., Brun, R., & Taşdemir, D. (2010) · Marine Drugs · doi:10.3390/md8010047 · Cited by 185
Self-citation
100 Years of Suramin
Wiedemar, N., Hauser, D. A., & Mäser, P. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01168-19 · Cited by 184
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
Vincent, I. M., Creek, D. J., Watson, D. G., Kamleh, M. A., Woods, D. J., Wong, P. E., Burchmore, R., & Barrett, M. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001204 · Cited by 183
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
Yin, W., Luan, X., Li, Z., Zhou, Z., Wang, Q., Gao, M., Wang, X., Zhou, F., Shi, J., You, E., et al. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00570-0 · Cited by 185
Sleeping sickness
Malvy, D. J.-M., & Chappuis, F. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03536.x · Cited by 176
Self-citation
Cardiac Involvement with Parasitic Infections
Hidrón, A., Vogenthaler, N. S., Santos, J. I., Rodriguez-Morales, A. J., Franco‐Paredes, C., & Rassi, A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-09 · Cited by 169
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes
Baker, N., Glover, L., Munday, J. C., Aguinaga, D., Barrett, M. P., de Koning, H. P., & Horn, D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202885109 · Cited by 158
Exocytosis and protein secretion in Trypanosoma
Geiger, A., Hirtz, C., Bécue, T., Bellard, E., Centeno, D., Gargani, D., Rossignol, M., Cuny, G., & Peltier, J. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-20 · Cited by 152
Natural-Products-Inspired Use of the gem -Dimethyl Group in Medicinal Chemistry
Talele, T. T. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00315 · Cited by 151
NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
Yun, O., Priotto, G., Tong, J., Flévaud, L., & Chappuis, F. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000720 · Cited by 141
Self-citation
Antiparasitic Therapy
Kappagoda, S., Singh, U., & Blackburn, B. G. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0203 · Cited by 141
Independent Analysis of the Flagellum Surface and Matrix Proteomes Provides Insight into Flagellum Signaling in Mammalian-infectious Trypanosoma brucei
Oberholzer, M., Langousis, G., Nguyen, H. T., Saada, E. A., Shimogawa, M. M., Jónsson, Z. O., Nguyen, S. M., Wohlschlegel, J. A., & Hill, K. L. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010538 · Cited by 145
Drug Resistance in Human African Trypanosomiasis
Barrett, M. P., Vincent, I. M., Burchmore, R., Kazibwe, A., & Matovu, E. (2011) · Future Microbiology · doi:10.2217/fmb.11.88 · Cited by 138
Development of Novel Drugs for Human African Trypanosomiasis
Brun, R., Don, R., Jacobs, R. T., Wang, M. Z., & Barrett, M. P. (2011) · Future Microbiology · doi:10.2217/fmb.11.44 · Cited by 138
Self-citation
Through the dark continent: African trypanosome development in the tsetse fly
Rotureau, B., & Abbeele, J. V. D. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00053 · Cited by 141
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis
Kennedy, P. G. E., & Rodgers, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00039 · Cited by 132
Predicting the effect of climate change on African trypanosomiasis: integrating epidemiology with parasite and vector biology
Moore, S. M., Shrestha, S., Tomlinson, K. W., & Vuong, H. B. (2011) · Journal of The Royal Society Interface · doi:10.1098/rsif.2011.0654 · Cited by 130
Human African Trypanosomiasis in Non‐Endemic Countries (2000–2010)
Simarro, P. P., Franco, J. R., Cecchi, G., Paone, M., Diarra, A., Ruiz-Postigo, J. A., & Jannin, J. G. (2011) · Journal of Travel Medicine · doi:10.1111/j.1708-8305.2011.00576.x · Cited by 127
A Cell-surface Phylome for African Trypanosomes
Jackson, A. P., Allison, H. C., Barry, J. D., Field, M. C., Hertz‐Fowler, C., & Berriman, M. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002121 · Cited by 127
Target Validation: Linking Target and Chemical Properties to Desired Product Profile
Wyatt, P. G., Gilbert, I. H., Read, K. D., & Fairlamb, A. H. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611795429185 · Cited by 131
Melarsoprol Resistance in African Trypanosomiasis
Fairlamb, A. H., & Horn, D. (2018) · Trends in Parasitology · doi:10.1016/j.pt.2018.04.002 · Cited by 125
Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites
Scala, F., Fattorusso, E., Menna, M., Taglialatela‐Scafati, O., Tierney, M. S., Kaiser, M., & Taşdemir, D. (2010) · Marine Drugs · doi:10.3390/md8072162 · Cited by 121
Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
Creek, D. J., Mazet, M., Achcar, F., Anderson, J. J., Kim, D., Kamour, R., Morand, P., Millerioux, Y., Biran, M., Kerkhoven, E. J., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004689 · Cited by 120
Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy
Tirados, I., Esterhuizen, J., Kovačić, V., Mangwiro, T. N. C., Vale, G. A., Hastings, I. M., Solano, P., Lehane, M. J., & Torr, S. J. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003822 · Cited by 118
Estimates of the duration of the early and late stage of gambiense sleeping sickness
Checchi, F., Filipe, J. A. N., Haydon, D. T., Chandramohan, D., & Chappuis, F. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-16 · Cited by 116
Self-citation
Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo
Alirol, E., Schrumpf, D., Heradi, J. A., Riedel, A., de Patoul, C., Quere, M., & Chappuis, F. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis886 · Cited by 114
Self-citation
Combatting African Animal Trypanosomiasis (AAT) in livestock: The potential role of trypanotolerance
Yaro, M., Munyard, K. A., Stear, M. J., & Groth, D. M. (2016) · Veterinary Parasitology · doi:10.1016/j.vetpar.2016.05.003 · Cited by 114
Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act
MacGregor, P., Szöőr, B., Savill, N. J., & Matthews, K. R. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2779 · Cited by 113
Phylogeography and Taxonomy of Trypanosoma brucei
Balmer, O., Beadell, J. S., Gibson, W. C., & Caccone, A. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000961 · Cited by 111
Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
Vincent, I. M., Creek, D. J., Burgess, K. E., Woods, D. J., Burchmore, R., & Barrett, M. P. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001618 · Cited by 110
Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism
Pieretti, S., Haanstra, J. R., Mazet, M., Perozzo, R., Bergamini, C., Prati, F., Fato, R., Lenaz, G., Capranico, G., Brun, R., et al. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002012 · Cited by 107
Self-citation
The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy
Franco, J. R., Simarro, P. P., DIARRA, A., Ruiz-Postigo, J. A., & Jannin, J. G. (2014) · Parasitology · doi:10.1017/s0031182013002102 · Cited by 107
Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis
Njoroge, M., Njuguna, N. M., Mutai, P., Ongarora, D. S. B., Smith, P. W., & Chibale, K. (2014) · Chemical Reviews · doi:10.1021/cr500098f · Cited by 107
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives
Hailu, G. S., Robaa, D., Forgione, M., Sippl, W., Rotili, D., & Mai, A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01595 · Cited by 110
Identifying Transmission Cycles at the Human-Animal Interface: The Role of Animal Reservoirs in Maintaining Gambiense Human African Trypanosomiasis
Funk, S., Nishiura, H., Heesterbeek, H., Edmunds, W. J., & Checchi, F. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002855 · Cited by 105
Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
Nare, B., Wring, S. A., Bacchi, C. J., Beaudet, B., Bowling, T., Brun, R., Chen, D., Ding, C. Z., Freund, Y. R., Gaukel, E., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00498-10 · Cited by 104
Self-citation
Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies
Tarral, A., Blesson, S., Mordt, O. V., Torreele, E., Sassella, D., Bray, M. A., Hovsepian, L., Evène, E., Gualano, V., Felices, M., et al. (2014) · Clinical Pharmacokinetics · doi:10.1007/s40262-014-0136-3 · Cited by 107
Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes
Guilliam, T. A., Keen, B. A., Brissett, N. C., & Doherty, A. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv625 · Cited by 99
Importance of Nonenteric Protozoan Infections in Immunocompromised People
Barratt, J., HARKNESS, J., Marriott, D., Ellis, J., & Stark, D. J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-10 · Cited by 99
Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis
Bowling, T., Mercer, L., Don, R., Jacobs, R. T., & Nare, B. (2012) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2012.02.002 · Cited by 98
Treatment options for second-stage gambiense human African trypanosomiasis
Éperon, G., Balasegaram, M., Potet, J., Mowbray, C. E., Valverde, O., & Chappuis, F. (2014) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2014.959496 · Cited by 102
Self-citation
Neuropathology of Naturally Occurring Trypanosoma evansi Infection of Horses
Rodrigues, A., Fighera, R. A., de Souza, T. M. G., Schild, A. L., & Barros, C. S. L. (2009) · Veterinary Pathology · doi:10.1354/vp.07-vp-0205-r-fl · Cited by 97
Isolation of anticancer and anti-trypanosome secondary metabolites from the endophytic fungus Aspergillus flocculus via bioactivity guided isolation and MS based metabolomics
Tawfike, A., Romli, M. F., Clements, C. J., Abbott, G. M., Young, L., Schumacher, M. M., Diederich, M. F., Farag, M. A., & Edrada‐Ebel, R. (2019) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.12.032 · Cited by 98
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Graf, F. E., Ludin, P., Wenzler, T., Kaiser, M., Brun, R., Pyana, P. P., Büscher, P., de Koning, H. P., Horn, D., & Mäser, P. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002475 · Cited by 95
Self-citation
ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation
Subota, I., Rotureau, B., Blisnick, T., Ngwabyt, S., Durand‐Dubief, M., Engstler, M., & Bastin, P. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0511 · Cited by 93
Vesicles as carriers of virulence factors in parasitic protozoan diseases
Torrecilhas, A. C., Schumacher, R. I., Alves, M. J. M., & Colli, W. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.07.008 · Cited by 93
The within-host dynamics of African trypanosome infections
Matthews, K. R., McCulloch, R., & Morrison, L. J. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0288 · Cited by 92
Sensitivity and specificity of HAT Sero-K-SeT, a rapid diagnostic test for serodiagnosis of sleeping sickness caused by Trypanosoma brucei gambiense: a case-control study
Büscher, P., Mertens, P., Leclipteux, T., Gilleman, Q., JACQUET, D., Ngoyi, D. M., Pyana, P. P., Boelaert, M., & Lejon, V. (2014) · The Lancet Global Health · doi:10.1016/s2214-109x(14)70203-7 · Cited by 92
Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents
Qiao, Z., Wang, Q., Zhang, F., Wang, Z., Bowling, T., Nare, B., Jacobs, R. T., Zhang, J., Ding, D., Liu, Y., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm2012408 · Cited by 92
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei
Munday, J. C., Settimo, L., & de Koning, H. P. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00032 · Cited by 92
Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets
de Koning, H. P., Gould, M. K., Sterk, G. J., Tenor, H., Kunz, S., Luginbuehl, E., & Seebeck, T. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir857 · Cited by 90
Revisiting the Immune Trypanolysis Test to Optimise Epidemiological Surveillance and Control of Sleeping Sickness in West Africa
Jamonneau, V., Bucheton, B., Kaboré, J., Ilboudo, H., Camara, O., Courtin, F., Solano, P., Kaba, D., Kambiré, R., Kouakou, L., et al. (2010) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000917 · Cited by 90
Antiparasitic agents: new drugs on the horizon
Mäser, P., Wittlin, S., Rottmann, M., Wenzler, T., Kaiser, M., & Brun, R. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.05.001 · Cited by 89
Self-citation
The Natural Progression of Gambiense Sleeping Sickness: What Is the Evidence?
Checchi, F., Filipe, J. A. N., Barrett, M. P., & Chandramohan, D. (2008) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000303 · Cited by 89
Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis
Arias, J. L., Unciti-Broceta, J. D., Maceira, J., del Castillo, T., Hernández-Quero, J., Magez, S., Soriano, M., & García-Salcedo, J. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.002 · Cited by 88
A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly
Rotureau, B., Subota, I., Buisson, J., & Bastin, P. (2012) · Development · doi:10.1242/dev.072611 · Cited by 87
Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests
Becker, S. L., Vogt, J., Knopp, S., Panning, M., Warhurst, D. C., Polman, K., Marti, H., von Müller, L., Yansouni, C. P., Jacobs, J. A., et al. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-37 · Cited by 89
Self-citation
Insect antimicrobial peptides act synergistically to inhibit a trypanosome parasite
Marxer, M., Vollenweider, V., & Schmid‐Hempel, P. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0302 · Cited by 86
Digital and technological innovation in vector-borne disease surveillance to predict, detect, and control climate-driven outbreaks
Pley, C., Evans, M., Lowe, R., Montgomery, H., & Yacoub, S. (2021) · The Lancet Planetary Health · doi:10.1016/s2542-5196(21)00141-8 · Cited by 88
Trypanosoma brucei: Chemical evidence that cathepsin L is essential for survival and a relevant drug target
Steverding, D., Sexton, D. W., Wang, X., Gehrke, S. S., Wagner, G. K., & Caffrey, C. R. (2012) · International Journal for Parasitology · doi:10.1016/j.ijpara.2012.03.009 · Cited by 83
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
Zeng, J., Weissmann, F., Bertolin, A. P., Posse, V., Canal, B., Ulferts, R., Wu, M., Harvey, R., Hussain, S., Milligan, J. C., et al. (2021) · Biochemical Journal · doi:10.1042/bcj20210201 · Cited by 81
Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis inTrypanosoma brucei
McAllaster, M. R., Ikeda, K. N., Lozano-Núñez, A., Anrather, D., Unterwurzacher, V., Gossenreiter, T., Perry, J. A., Crickley, R., Mercadante, C. J., Vaughan, S., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-04-0219 · Cited by 79
Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites
Varikuti, S., Jha, B. K., Volpedo, G., Ryan, N. M., Halsey, G., Hamza, O., McGwire, B. S., & Satoskar, A. R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02655 · Cited by 76
Nodding syndrome in Mundri county, South Sudan: Environmental, nutritional and infectious factors
Spencer, P. S., Vandemaele, K., Richer, M., Palmer, V., Chungong, S., Anker, M., Ayana, Y., Opoka, M., Klaucke, B., Quarello, A., et al. (2013) · African Health Sciences · doi:10.4314/ahs.v13i2.2 · Cited by 73
Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection
Koh, C. Y., Kim, J. E., Shibata, S., Ranade, R. M., Yu, M., Liu, J., Gillespie, J. R., C, F. S. B. A., Verlinde, C. L. M. J., Fan, E., et al. (2012) · Structure · doi:10.1016/j.str.2012.07.011 · Cited by 73
A unified multi-kingdom Golden Gate cloning platform
Chiasson, D. M., Giménez-Oya, V., Bircheneder, M., Bachmaier, S., Studtrucker, T., Ryan, J., Sollweck, K., Leonhardt, H., Boshart, M., Dietrich, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-46171-2 · Cited by 76
African animal trypanosomiasis as a constraint to livestock health and production in Karamoja region: a detailed qualitative and quantitative assessment
Muhanguzi, D., Mugenyi, A., Bigirwa, G., Kamusiime, M., Kitibwa, A., Akurut, G. G., Ochwo, S., Amanyire, W., Okech, S. G., Hattendorf, J., et al. (2017) · BMC Veterinary Research · doi:10.1186/s12917-017-1285-z · Cited by 72
Arsenic-Based Drugs: From Fowler’s Solution to Modern Anticancer Chemotherapy
Gibaud, S., & Jaouen, G. (2010) · Topics in organometallic chemistry · doi:10.1007/978-3-642-13185-1_1 · Cited by 71
Genetic Inhibition of APOL1 Pore-Forming Function Prevents APOL1-Mediated Kidney Disease
Hung, A. M., Assimon, V. A., Chen, H., Yu, Z., Vlasschaert, C., Triozzi, J. L., Chan, H., Wheless, L., Wilson, O. D., Shah, S. C., et al. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000219 · Cited by 70
Recent Advances in the Discovery of Novel Antiprotozoal Agents
Lee, S.-M., Kim, M.-S., Hayat, F., & Shin, D.-Y. (2019) · Molecules · doi:10.3390/molecules24213886 · Cited by 56
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis
Rodgers, J., Stone, T. W., Barrett, M. P., Bradley, B., & Kennedy, P. G. E. (2009) · Brain · doi:10.1093/brain/awp074 · Cited by 69
Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle
Rotureau, B., Subota, I., & Bastin, P. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01566.x · Cited by 68
Diagnostic Accuracy of PCR in gambiense Sleeping Sickness Diagnosis, Staging and Post-Treatment Follow-Up: A 2-year Longitudinal Study
Deborggraeve, S., Lejon, V., Ekangu, R. A., Ngoyi, D. M., Pyana, P. P., Ilunga, M., Mulunda, J. P., & Büscher, P. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000972 · Cited by 68
In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis
Myburgh, E., Coles, J. A., Ritchie, R., Kennedy, P. G. E., McLatchie, A. P., Rodgers, J., Taylor, M. C., Barrett, M. P., Brewer, J. M., & Mottram, J. C. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002384 · Cited by 68
Tsetse Control and the Elimination of Gambian Sleeping Sickness
Lehane, M., Alfaroukh, I. O., Bucheton, B., Camara, M., Harris, A., Kaba, D., Lumbala, C., Péka, M., Rayaissé, J.-B., Waiswa, C., et al. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004437 · Cited by 68
Natural products as mediators of disease
Garg, N., Luzzatto‐Knaan, T., Melnik, A. V., Caraballo‐Rodríguez, A. M., Floros, D. J., Petras, D., Gregor, R., Dorrestein, P. C., & Phelan, V. V. (2016) · Natural Product Reports · doi:10.1039/c6np00063k · Cited by 70
The activity of Artemisia spp. and their constituents against Trypanosomiasis
Naß, J., & Efferth, T. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.06.002 · Cited by 68

Authors: Brun, R., Blum, J., Chappuis, F., & Burri, C.
Affiliations: Swiss Tropical and Public Health Institute (CH)
Corresponding author: Brun, Reto
ORCID: Blum, Johannes
Burri, Christian
Venue: The Lancet
Publisher: Elsevier BV
Published: 2010-01
Volume: 375
Issue: 9709
Pages: 148-159
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(09)60829-1
OpenAlex: W2151877638
Cited by: 926
References: 300
Citations by year: 2026: 20 · 2025: 20 · 2024: 35 · 2023: 40 · 2022: 35 · 2021: 47 · 2020: 39 · 2019: 50 · 2018: 49 · 2017: 69 · 2016: 71 · 2015: 78 · 2014: 74 · 2013: 85 · 2012: 85
FWCI: 45.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Medecins Sans Frontieres Field Research (Medecins Sans Frontieres) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords: sleeping sickness, Trypanosoma brucei gambiense, tsetse flies, neglected tropical diseases, disease resurgence, political instability, vector control, disease elimination, clinical features, diagnosis, treatment, adverse drug reactions, sub-Saharan Africa
MeSH terms: Africa, Eflornithine, Animals, Communicable Disease Control, Humans, Insect Bites and Stings, Insect Vectors, Melarsoprol, Pentamidine, Suramin, Trypanocidal Agents, Trypanosoma brucei gambiense, Trypanosomiasis, African, Tsetse Flies, Variant Surface Glycoproteins, Trypanosoma, Incidence, Endemic Diseases, Biomedical Research

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human African trypanosomiasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks