The DOI matches its Crossref record; 103 of the 104 references it cites were found in a registry or an index.
Myocarditis
Open accessAbstract
Myocarditis is an underdiagnosed cause of acute heart failure, sudden death, and chronic dilated cardiomyopathy. In developed countries, viral infections commonly cause myocarditis; however, in the developing world, rheumatic carditis, Trypanosoma cruzi, and bacterial infections such as diphtheria still contribute to the global burden of the disease. The short-term prognosis of acute myocarditis is usually good, but varies widely by cause. Those patients who initially recover might develop recurrent dilated cardiomyopathy and heart failure, sometimes years later. Because myocarditis presents with non-specific symptoms including chest pain, dyspnoea, and palpitations, it often mimics more common disorders such as coronary artery disease. In some patients, cardiac MRI and endomyocardial biopsy can help identify myocarditis, predict risk of cardiovascular events, and guide treatment. Finding effective therapies has been challenging because the pathogenesis of chronic dilated cardiomyopathy after viral myocarditis is complex and determined by host and viral genetics as well as environmental factors. Findings from recent clinical trials suggest that some patients with chronic inflammatory cardiomyopathy have a progressive clinical course despite standard medical care and might improve with a short course of immunosuppression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Giant cell myocarditis is a rare but rapidly progressing condition associated with a high risk of death or the necessity for heart transplantation.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [186]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Eosinophilic myocarditis is characterized by a predominant infiltration of eosinophils in the myocardium”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [186]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“leading to advanced heart disorders such as heart failure, fibrosis, and thrombosis.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [186]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“can show either diffuse STsegment elevations or ST-segment elevation in a coronary distribution.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [186]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“various conditions including infections, drugs, hypersensitivity, and autoimmune factors may be associated with the onset and progress of this disease.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [186]
The cited source says what the claim attributes to it.
In the citing paper
“The ECG is abnormal in the majority of patients with myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [186]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,700
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,739
Authors Task Force Members, Dickstein, K., Solal, A. C., Filippatos, G., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn309 · Cited by 2,710
Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper
Friedrich, M. G., Sechtem, U. P., Schulz‐Menger, J., Holmvang, G., Alakija, P., Cooper, L. T., White, J. A., Abdel‐Aty, H., Gutberlet, M., Prasad, S. K., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.007 · Cited by 2,523
Self-citationHunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.013 · Cited by 1,398
Cooper, L. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0800028 · Cited by 1,325
Self-citationHFSA 2010 Comprehensive Heart Failure Practice Guideline
Heart Failure Society of America (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.04.004 · Cited by 1,304
A Clinical Trial of Immunosuppressive Therapy for Myocarditis
Mason, J. W., O'Connell, J. B., Herskowitz, A., Rose, N. R., McManus, B. M., Billingham, M. E., & Moon, T. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330501 · Cited by 1,274
Cardiovascular Magnetic Resonance, Fibrosis, and Prognosis in Dilated Cardiomyopathy
Assomull, R. G., Prasad, S. K., Lyne, J. C., Smith, G., Burman, E., KHAN, M. G., Sheppard, M. N., Poole-Wilson, P. A., & Pennell, D. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.049 · Cited by 1,163
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178233 · Cited by 1,080
Research works printed but not linked: 3
- Marques, 2006, Evaluation of asymptomatic patients with chronic Chagas disease through ambulatory electrocardiogram, echocardiogram and B-Type natriuretic peptide analyses, Arq Bras Cardiol, 87, 336
- Park, 2009, In-hospital prognostic factors in patients with acute myocarditis, J Am Coll Cardiol, 53, A144
- Alvarez, 2011, Competing risks for death and cardiac transplantation in children with dilated cardiomyopathy, Circulation, 124, 814, 10.1161/CIRCULATIONAHA.110.973826 · DOI
Cited by
Sorted by citations
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Caforio, A. L. P., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S. B., Fu, M., Heliö, T., Heymans, S., Jahns, R., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht210 · Cited by 3,479
Zeppenfeld, K., Tfelt‐Hansen, J., Riva, M., Winkel, B. G., Behr, E. R., Blom, N. A., Charron, P., Corrado, D., Dagres, N., de Chillou, C., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac262 · Cited by 3,432
Al‐Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T. M., Field, M. E., Fonarow, G. C., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.054 · Cited by 1,902
Bozkurt, B., Colvin, M. M., Cook, J., Cooper, L. T., Deswal, A. M., Fonarow, G. C., Francis, G. S., Lenihan, D. J., Lewis, E. F., McNamara, D. M., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000455 · Cited by 920
Self-citation
Metadata
- Authors
- Sagar, S., Liu, P. P., & Cooper, L. T.
- Affiliations
- Mayo Clinic (US)
- University Health Network (CA)
- Corresponding author
- Cooper, Leslie T
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 379
- Issue
- 9817
- Pages
- 738-747
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC5814111
- OpenAlex
- W4240413437
- Cited by
- 743
- References
- 104
- Citations by year
- 2026: 41 · 2025: 83 · 2024: 89 · 2023: 81 · 2022: 79 · 2021: 60 · 2020: 44 · 2019: 58 · 2018: 34 · 2017: 42 · 2016: 38 · 2015: 34 · 2014: 24 · 2013: 25 · 2012: 11
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R56HL056267, R01HL056267)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Pericarditis and Cardiac Tamponade
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- myocarditis, viral myocarditis, dilated cardiomyopathy, acute heart failure, sudden cardiac death, rheumatic carditis, Trypanosoma cruzi, diphtheria, cardiac MRI, endomyocardial biopsy, immunosuppression, prognosis, pathogenesis
- MeSH terms
- Acute Disease, Bacterial Infections, Humans, Myocarditis, Prognosis, Virus Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
