The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Chronic obstructive pulmonary disease
Open accessAbstract
Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow obstruction that is only partly reversible, inflammation in the airways, and systemic effects or comorbities. The main cause is smoking tobacco, but other factors have been identified. Several pathobiological processes interact on a complex background of genetic determinants, lung growth, and environmental stimuli. The disease is further aggravated by exacerbations, particularly in patients with severe disease, up to 78% of which are due to bacterial infections, viral infections, or both. Comorbidities include ischaemic heart disease, diabetes, and lung cancer. Bronchodilators constitute the mainstay of treatment: β2 agonists and long-acting anticholinergic agents are frequently used (the former often with inhaled corticosteroids). Besides improving symptoms, these treatments are also thought to lead to some degree of disease modification. Future research should be directed towards the development of agents that notably affect the course of disease.
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Cites
Celli, B. R., Cote, C. G., Marin, J. M., Casanova, C., Montes de Oca, M., Mendez, R. A., Pinto Plata, V., & Cabral, H. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa021322 · Cited by 4,015
Pulmonary rehabilitation for chronic obstructive pulmonary disease
McCarthy, B., Casey, D., Devane, D., Murphy, K., Murphy, E., & Lacasse, Y. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003793.pub3 · Cited by 2,643
Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581
Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
Pitta, F., Troosters, T., Spruit, M. A., Probst, V. S., Decramer, M., & Gosselink, R. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-855oc · Cited by 1,256
Self-citationThe Effects of a Smoking Cessation Intervention on 14.5-Year Mortality: A Randomized Clinical Trial
Anthonisen, N. R., Skeans, M. A., Wise, R. A., Manfreda, J., Kanner, R. E., Connett, J. E., & for the Lung Health Study Research Group* (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-4-200502150-00005 · Cited by 1,237
Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations
Papi, A., Bellettato, C. M., Braccioni, F., Romagnoli, M., Casolari, P., Caramori, G., Fabbri, L. M., & Johnston, S. L. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-859oc · Cited by 1,072
Mortality in COPD: role of comorbidities
Sin, D. D., Anthonisen, N. R., Soriano, J. B., & Agusti, A. G. (2006) · European Respiratory Journal · doi:10.1183/09031936.00133805 · Cited by 1,052
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000
Complex chronic comorbidities of COPD
Fabbri, L. M., Luppi, F., Beghé, B., & Rabe, K. F. (2008) · European Respiratory Journal · doi:10.1183/09031936.00114307 · Cited by 660 · cited 2×
“73, 74 No randomised controlled trials have yet been done to investigate whether treatment with broncho dilators or inhaled corticosteroids reduces the prevalence or severity of comorbidities.”
Alveolar Cell Senescence in Patients with Pulmonary Emphysema
Tsuji, T., Aoshiba, K., & Nagai, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1374oc · Cited by 527
Cited by
Alveolar macrophages: plasticity in a tissue-specific context
Hussell, T., & Bell, T. J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3600 · Cited by 1,377
An official European Respiratory Society statement on physical activity in COPD
Watz, H., Pitta, F., Rochester, C. L., Garcia-Aymerich, J., ZuWallack, R., Troosters, T., Vaes, A. W., Puhan, M. A., Jehn, M., Polkey, M. I., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00046814 · Cited by 526
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
Schuliga, M. (2015) · Biomolecules · doi:10.3390/biom5031266 · Cited by 428
The clinical and economic burden of chronic obstructive pulmonary disease in the USA
Ray, S., Guarascio, Finch, & Self, T. (2013) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s34321 · Cited by 425
El Shayeb, M., Topfer, L.-A., Stafinski, T., Pawluk, L., & Menon, D. (2014) · Canadian Medical Association Journal · doi:10.1503/cmaj.130952 · Cited by 237
Metadata
- Authors
- Decramer, M., Janssens, W., & Miravitlles, M.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 379
- Issue
- 9823
- Pages
- 1341-1351
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2740155436
- Cited by
- 972
- References
- 12
- FWCI
- 81.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Decramer, M., Janssens, W., & Miravitlles, M. (2012). Chronic obstructive pulmonary disease. The Lancet. https://doi.org/10.1016/s0140-6736(11)60968-9
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
