Complex chronic comorbidities of COPD

Fabbri, L. M.; Luppi, F.; Beghé, B.; Rabe, K. F.

doi:10.1183/09031936.00114307

Cited by 660Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

Complex chronic comorbidities of COPD

Open access

Fabbri, L. M., Luppi, F., Beghé, B., Rabe, K. F.·2008·European Respiratory Journal

DOI 10.1183/09031936.00114307

Open this paper in CoChat — free account

Abstract

Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke. The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences. A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation. As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.

Integrity signals

Registry

Crossref · 10.1183/09031936.00114307

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Harrison's Principles of Internal Medicine.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-499_2 · Cited by 12,528 · see citing works
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T., & Murray, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68770-9 · Cited by 5,630 · see citing works
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: GOLD Executive Summary
Rabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925 · see citing works
Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
Celli, B. R., MacNee, W., Agustí, A. G. N., Anzueto, A. R., Berg, B., Buist, A. S., Calverley, P. M., Chavannes, N. H., Dillard, T. A., Fahy, B. F., et al. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00014304 · Cited by 4,414 · see citing works
The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
Celli, B. R., Cote, C. G., Marin, J. M., Casanova, C., Montes de Oca, M., Mendez, R. A., Pinto Plata, V., & Cabral, H. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa021322 · Cited by 4,015 · see citing works
Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary Disease
CALVERLEY, P. M. A., Anderson, J. A., Celli, B. R., Ferguson, G. T., Jenkins, C. R., Jones, P., Yates, J., & Vestbo, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063070 · Cited by 3,233 · see citing works
2003 European Society of Hypertension???European Society of Cardiology guidelines for the management of arterial hypertension*
Guidelines Committee (2003) · Journal of Hypertension · doi:10.1097/00004872-200306000-00001 · Cited by 3,015 · see citing works
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814 · see citing works
2003 European society of hypertension - European Society of Cardiology guidelines for the management of arterial hypertension
Mancia, G., Rosei, E. A., Cífková, R., DeBacker, G., Erdine, S. E., Fagard, R., Farsang, C., Heagerty, A. M., Kawecka-Jaszcs, K., Kiowski, W., et al. (2003) · Lirias (KU Leuven) · doi:10.1097/01.hjh.0000059051.65882.32 · Cited by 2,601 · see citing works
Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance
Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581 · see citing works
Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005)
Swedberg, K. B., Cleland, J. G. F., Dargie, H., Drexler, H., Folláth, F., Michel Komajda, N., Tavazzi, L., Smiseth, O. A., Gavazzi, A., Haverich, A., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi204 · Cited by 2,243 · see citing works
Continuous or Nocturnal Oxygen Therapy in Hypoxemic Chronic Obstructive Lung Disease
NOCTURNAL OXYGEN THERAPY TRIAL GROUP (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-3-391 · Cited by 2,202 · see citing works
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works
Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
Gan, W. (2004) · Thorax · doi:10.1136/thx.2003.019588 · Cited by 1,819 · see citing works
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary
Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M., Cosentino, F., Jönsson, B., Laakso, M., Malmberg, K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl260 · Cited by 1,638 · see citing works
Obesity in Adulthood and Its Consequences for Life Expectancy: A Life-Table Analysis
Peeters, A., Barendregt, J. J., Willekens, F., Mackenbach, J. P., Mamun, A. A., & Bonneux, L. G. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-1-200301070-00008 · Cited by 1,476 · see citing works
Estimates of global mortality attributable to smoking in 2000
Ezzati, M., & Lopez, A. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14338-3 · Cited by 1,247 · see citing works
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,241 · see citing works
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., JOSHIPURA, K. J., Curhan, G. C., Rifai, N., Cannuscio, C. C., Stampfer, M. J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040967 · Cited by 1,174 · see citing works
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
Kasahara, Y., Tuder, R. M., Taraseviciene‐Stewart, L., Cras, T. D. L., Abman, S. H., Hirth, P., Waltenberger, J. L., & Voelkel, N. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10259 · Cited by 1,110 · see citing works
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study
Schmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,069 · see citing works
Mortality in COPD: role of comorbidities
Sin, D. D., Anthonisen, N. R., Soriano, J. B., & Agusti, A. G. (2006) · European Respiratory Journal · doi:10.1183/09031936.00133805 · Cited by 1,052 · see citing works
Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study
Hole, D. J., Watt, G. C. M., Davey-Smith, G., Hart, C., Gillis, C. R., & Hawthorne, V. M. (1996) · BMJ · doi:10.1136/bmj.313.7059.711 · Cited by 910 · see citing works
LONG TERM DOMICILIARY OXYGEN THERAPY IN CHRONIC HYPOXIC COR PULMONALE COMPLICATING CHRONIC BRONCHITIS AND EMPHYSEMA
(1981) · The Lancet · doi:10.1016/s0140-6736(81)91970-x · Cited by 880 · see citing works
Oxidative Stress in Chronic Obstructive Pulmonary Disease
Repine, J. E., Bast, A., & Lankhorst, I. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.2.9611013 · Cited by 849 · see citing works
Cachexia: pathophysiology and clinical relevance1,2
Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786 · see citing works
Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure
Braunstein, J. B., Anderson, G. F., Gerstenblith, G., Weller, W. E., Niefeld, M. R., Herbert, R. J., & Wu, A. W. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00947-1 · Cited by 778 · see citing works
Systemic oxidative stress in asthma, COPD, and smokers
Rahman, I., Morrison, D., Donaldson, K., & MacNee, W. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.4.8887607 · Cited by 774 · see citing works
From COPD to chronic systemic inflammatory syndrome?
Fabbri, L. M., & Rabe, K. F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61383-x · Cited by 633 · see citing works
Patterns of Comorbidities in Newly Diagnosed COPD and Asthma in Primary Care
Soriano, J. B., Visick, G. T., Muellerova, H., Payvandi, N., & Hansell, A. L. (2005) · Chest · doi:10.1378/chest.128.4.2099 · Cited by 615 · see citing works
Antielastin autoimmunity in tobacco smoking–induced emphysema
Lee, S., Goswami, S., Grudo, A., Song, L., Bandi, V., Goodnight-White, S., Green, L., Hacken, J. B., Huh, J., Bakaeen, F. G., et al. (2007) · Nature Medicine · doi:10.1038/nm1583 · Cited by 592 · see citing works
Chronic Obstructive Pulmonary Disease as a Risk Factor for Cardiovascular Morbidity and Mortality
Sin, D. D., & Man, S. F. P. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200404-032ms · Cited by 572 · see citing works
Cardiovascular Effects of β-Agonists in Patients With Asthma and COPD
Salpeter, S. R., Ormiston, T. M., & Salpeter, E. E. (2004) · CHEST Journal · doi:10.1378/chest.125.6.2309 · Cited by 562 · see citing works
Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee
McGarvey, L. P., John, M. K., Anderson, J. A., Zvarich, M. T., & Wise, R. A. (2007) · Thorax · doi:10.1136/thx.2006.072348 · Cited by 560 · see citing works
The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly
Barzilay, J. I., Abraham, L., Heckbert, S. R., Cushman, M., Kuller, L. H., Resnick, H. E., & Tracy, R. P. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2384 · Cited by 543 · see citing works
COPD and Incident Cardiovascular Disease Hospitalizations and Mortality: Kaiser Permanente Medical Care Program
Sidney, S., Sorel, M. E., Quesenberry, C. P., de Luise, C., Lanes, S., & Eisner, M. D. (2005) · CHEST Journal · doi:10.1378/chest.128.4.2068 · Cited by 538 · see citing works
Inhaled corticosteroids for stable chronic obstructive pulmonary disease
Yang, I. A., Clarke, M., Sim, E., & Fong, K. M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002991.pub3 · Cited by 530 · see citing works
Altered Respiratory Physiology in Obesity
Parameswaran, K., Todd, D. C., & Soth, M. (2006) · Canadian Respiratory Journal · doi:10.1155/2006/834786 · Cited by 527 · see citing works
Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.
Schols, A. M. W. J., Buurman, W. A., den Brekel, A. J. S.-V., Dentener, M. A., & Wouters, E. F. �. (1996) · Thorax · doi:10.1136/thx.51.8.819 · Cited by 520 · see citing works
European guidelines on cardiovascular disease prevention in clinical practice
Backer, G. D., Ambrosioni, E., Borch‐Johnsen, K., Brotons, C., Cífková, R., Dallongeville, J., Ebrahim, S. B. J., Færgeman, O., Graham, I. D., Mancia, G., et al. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.10.001 · Cited by 493 · see citing works
Biology of Cachexia
Tisdale, M. J. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.23.1763 · Cited by 489 · see citing works
Physiologic Effects of Nutritional Support and Anabolic Steroids in Patients With Chronic Obstructive Pulmonary Disease. A Placebo-Controlled Randomized Trial
Schols, A. M. W. J., Soeters, P. B., Mostert, R., Pluymers, R. J., & Wouters, E. F. �. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.4.7551381 · Cited by 461 · see citing works
Tumor necrosis factor-α and muscle wasting: a cellular perspective
Reid, M. B., & Li, Y. (2001) · Respiratory Research · doi:10.1186/rr67 · Cited by 458 · see citing works
The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies
Poulain, M. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051299 · Cited by 413 · see citing works
Pulmonary and Systemic Oxidant/Antioxidant Imbalance in Chronic Obstructive Pulmonary Disease
MacNee, W. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200411-056sf · Cited by 410 · see citing works
Oxidative Stress and Apoptosis Interact and Cause Emphysema Due to Vascular Endothelial Growth Factor Receptor Blockade
Tuder, R. M., Zhen, L., Cho, C. Y., Tarasevičienė-Stewart, L., Kasahara, Y., Salvemini, D., Voelkel, N. F., & Flores, S. C. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0228oc · Cited by 391 · see citing works
Cachexia
Kotler, D. P. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-8-200010170-00015 · Cited by 385 · see citing works
Local and Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease: Soluble Tumor Necrosis Factor Receptors Are Increased in Sputum
Vernooy, J. H. J., Küçükaycan, M., Jacobs, J. A., Chavannes, N. H., Buurman, W. A., Dentener, M. A., & Wouters, E. F. �. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2202023 · Cited by 379 · see citing works
Harrison's principles of internal medicine
Kasper, D. L. 1., & Harrison, T. R. 1.-1. (2005) · Cited by 375 · see citing works
Arterial Stiffness and Osteoporosis in Chronic Obstructive Pulmonary Disease
Sabit, R., Bolton, C. E., Edwards, P. H., Pettit, R. J., Evans, W. D., McEniery, C. M., Wilkinson, I. B., Cockcroft, J. R., & Shale, D. J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-067oc · Cited by 373 · see citing works
Fitness and Fatness as Predictors of Mortality from All Causes and from Cardiovascular Disease in Men and Women in the Lipid Research Clinics Study
Stevens, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf114 · Cited by 370 · see citing works
Structural and inflammatory changes in COPD: a comparison with asthma.
Jeffery, P. K. (1998) · Thorax · doi:10.1136/thx.53.2.129 · Cited by 329 · see citing works
Global Initiative on Obstructive Lung Disease (GOLD) classification of lung disease and mortality: findings from the Atherosclerosis Risk in Communities (ARIC) study
Mannino, D. M., Doherty, D. E., & Buist, A. S. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.03.035 · Cited by 328 · see citing works
The Relationship between Chronic Hypoxemia and Activation of the Tumor Necrosis Factor- α System in Patients with Chronic Obstructive Pulmonary Disease
Takabatake, N., Nakamura, H., Abe, S., Inoue, S., Hino, T., SAITO, H., YUKI, H., Kato, S., & Tomoike, H. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.9903022 · Cited by 325 · see citing works
Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure
Jemtel, T. H. L., Padeletti, M., & Jelić, S. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.046 · Cited by 320 · see citing works
Forced expiratory volume in one second: not just a lung function test but a marker of premature death from all causes
Young, R. P., Hopkins, R. J., & Eaton, T. E. (2007) · European Respiratory Journal · doi:10.1183/09031936.00021707 · Cited by 306 · see citing works
Systemic Effects of Chronic Obstructive Pulmonary Disease
Agustí, A. G. N. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200504-026sr · Cited by 290 · see citing works
Heart Failure and cHronic Obstructive Pulmonary Disease: An Ignored Combination?
Rutten, F. H., Cramer, M. J., Lammers, J. J., Grobbee, D. E., & Hoes, A. W. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.01.010 · Cited by 290 · see citing works
Association between Corticosteroid Use and Vertebral Fractures in Older Men with Chronic Obstructive Pulmonary Disease
McEvoy, C., Ensrud, K. E., BENDER, E., Genant, H. K., Yu, W., Griffith, J. M., & Niewoehner, D. E. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.9703080 · Cited by 284 · see citing works
The Effect of Cigarette Smoking on Neutrophil Kinetics in Human Lungs
MacNee, W., Wiggs, B., Belzberg, A. S., & Hogg, J. C. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910053211402 · Cited by 283 · see citing works
Impact of comorbidity on lung cancer survival
Tammemägi, M. C., Neslund-Dudas, C. M., Simoff, M., & Kvale, P. A. (2002) · International Journal of Cancer · doi:10.1002/ijc.10882 · Cited by 282 · see citing works
Hypothesis: Does COPD have an autoimmune component?
Agustí, A. G. N. (2003) · Thorax · doi:10.1136/thorax.58.10.832 · Cited by 278 · see citing works
Risk factors for community-acquired pneumonia in adults: a population-based case-control study
Almirall, J., Bolíbar, I., Balanzó, X., & Gonzalez, C. (1999) · European Respiratory Journal · doi:10.1183/09031936.99.13234999 · Cited by 271 · see citing works
Chronic Obstructive Pulmonary Disease, Asthma, and Risk of Type 2 Diabetes in Women
Rana, J. S., Mittleman, M. A., Sheikh, J. K., Hu, F. B., Manson, J. E., Colditz, G. A., Speizer, F. E., Barr, R. G., & Camargo, C. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2478 · Cited by 267 · see citing works
The natural history of chronic obstructive pulmonary disease
Mannino, D. M., Watt, G. C. M., Hole, D. J., Gillis, C. R., Hart, C., McConnachie, A., Smith, G. D., Upton, M. N., Hawthorne, V. M., Sin, D. D., et al. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00024605 · Cited by 262 · see citing works
Exercise-induced Quadriceps Oxidative Stress and Peripheral Muscle Dysfunction in Patients with Chronic Obstructive Pulmonary Disease
Couillard, A., Maltais, F., Saey, D., Debigaré, R., Michaud, A., Koechlin‐Ramonatxo, C., Leblanc, P., & PREFAUT, C. G. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-1028oc · Cited by 257 · see citing works
Simvastatin Inhibits Cigarette Smoking–induced Emphysema and Pulmonary Hypertension in Rat Lungs
Lee, J., Lee, D.-S., Kim, E., Choe, K., Oh, Y.-M., Shim, T. S., Kim, S.-E., Lee, Y., & Lee, S. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200501-041oc · Cited by 256 · see citing works
Chronic Obstructive Pulmonary Disease Is Associated with an Increase in Urinary Levels of Isoprostane F2 α-III, an Index of Oxidant Stress
Praticò, D., Basili, S., Vieri, M., Cordova, C., Violi, F., & FitzGerald, G. A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9709066 · Cited by 254 · see citing works
Oxidative Stress and Respiratory Muscle Dysfunction in Severe Chronic Obstructive Pulmonary Disease
Barreiro, E., de la Puente, B., Minguella, J., Corominas, J. M., Serrano, S., Hussain, S. N. A., & Gea, J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-887oc · Cited by 244 · see citing works
What do chronic obstructive pulmonary disease patients die from? Amultiple cause coding analysis
Hansell, A., Walk, J. A., & Soriano, J. B. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00031403 · Cited by 241 · see citing works
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity – a common inflammatory phenotype?
Sevenoaks, M. J., & Stockley, R. A. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-70 · Cited by 238 · see citing works
Recognising heart failure in elderly patients with stable chronic obstructive pulmonary disease in primary care: cross sectional diagnostic study
Rutten, F. H., Moons, K. G. M., Cramer, M. J., Grobbee, D. E., Zuithoff, N. P. A., Lammers, A.-W. J., & Hoes, A. W. (2005) · BMJ · doi:10.1136/bmj.38664.661181.55 · Cited by 238 · see citing works
Peripheral Muscle Wasting in Chronic Obstructive Pulmonary Disease
Debigaré, R., Côt́e, C. H., & Maltais, F. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.9.2104035 · Cited by 230 · see citing works
Preventing chronic diseases: taking stepwise action
Epping‐Jordan, J. E., Galea, G., Tukuitonga, C., & Beaglehole, R. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67342-4 · Cited by 229 · see citing works
The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease—A cross sectional study
Jørgensen, N. R., Schwarz, P., Holme, I., Henriksen, B. M., Petersen, L. J., & Backer, V. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.029 · Cited by 219 · see citing works
Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease?
MacNee, W., & Rahman, I. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)01912-8 · Cited by 217 · see citing works
Lovastatin Enhances Clearance of Apoptotic Cells (Efferocytosis) with Implications for Chronic Obstructive Pulmonary Disease
Morimoto, K., Janssen, W. J., Fessler, M. B., McPhillips, K. A., Borges, V. M., Bowler, R. P., Xiao, Y., Kench, J. A., Henson, P. M., & Vandivier, R. W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7657 · Cited by 215 · see citing works
State of the Art. Chronic Obstructive Pulmonary Disease, Inflammation, and Lung Cancer
Brody, J. S., & Spira, A. E. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200603-089ms · Cited by 215 · see citing works
Prospective Association Between Lung Function and the Incidence of Diabetes
Ford, E. S., & Mannino, D. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2966 · Cited by 194 · see citing works
Systemic Response to Ambient Particulate Matter: Relevance to Chronic Obstructive Pulmonary Disease
van Eeden, S. F., Yeung, A., Quinlam, K., & Hogg, J. C. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200406-035ms · Cited by 193 · see citing works
Systemic inflammation in chronic obstructive pulmonary disease
Oudijk, E. D., Lammers, J., & Koenderman, L. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004603a · Cited by 193 · see citing works
An Animal Model of Autoimmune Emphysema
Taraseviciene‐Stewart, L., Scerbavicius, R., Choe, K., Moore, M., Sullivan, A. K., Nicolls, M. R., Fontenot, A. P., Tuder, R. M., & Voelkel, N. F. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200409-1275oc · Cited by 187 · see citing works
Characterization of Nonresponse to High Caloric Oral Nutritional Therapy in Depleted Patients with Chronic Obstructive Pulmonary Disease
Creutzberg, E. C., Schols, A. M. W. J., Weling-Scheepers, C. A., Buurman, W. A., & Wouters, E. F. �. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.3.9808075 · Cited by 186 · see citing works
The Metabolic Syndrome in Patients With Chronic Obstructive Pulmonary Disease
Marquis, K., Maltais, F., Duguay, V., Bezeau, A.-M., LeBlanc, P., Jobin, J., & Poirier, P. (2005) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200507000-00010 · Cited by 179 · see citing works
Lung function decline and outcomes in an elderly population
Mannino, D. M. (2006) · Thorax · doi:10.1136/thx.2005.052449 · Cited by 178 · see citing works
The natural history of chronic obstructive pulmonary disease
Mannino, D. M., & Hudson, N. L. (2009) · Explore Bristol Research · doi:10.1183/09031936.06.00024605 · Cited by 176 · see citing works
The Growing Burden of Chronic Obstructive Pulmonary Disease and Lung Cancer in Women
Cohen, S. B.-Z., Paré, P. D., Man, S. F. P., & Sin, D. D. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1655pp · Cited by 175 · see citing works
How Viral Infections Cause Exacerbation of Airway Diseases
Mallia, P., & Johnston, S. L. (2006) · CHEST Journal · doi:10.1378/chest.130.4.1203 · Cited by 175 · see citing works
The neglected epidemic of chronic disease
Horton, R. C. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67454-5 · Cited by 168 · see citing works
The response of human bone marrow to chronic cigarette smoking
van Eeden, S. F., & Hogg, J. C. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.15e18.x · Cited by 161 · see citing works
Increased tumour necrosis factor‐α plasma levels during moderate-intensity exercise in COPD patients
Rabinovich, R., Figueras, M., Ardite, E., Carbó, N., Troosters, T., Filella, X., Barberà, J. A., Fernández-Checa, J. C., Argilés, J. M. A., & Roca, J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00042702 · Cited by 161 · see citing works
Structure and function of the respiratory muscles in patients with COPD: impairment or adaptation?: Fig. 1.—
Orozco-Levi, M. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004607 · Cited by 158 · see citing works
Oligoclonal CD4+ T Cells in the Lungs of Patients with Severe Emphysema
Sullivan, A. K., Simonian, P. L., Falta, M. T., Mitchell, J. D., Cosgrove, G. P., Brown, K. K., Kotzin, B. L., Voelkel, N. F., & Fontenot, A. P. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200410-1332oc · Cited by 154 · see citing works
Potential misclassification of causes of death from COPD
Jensen, H. H., Godtfredsen, N. S., Lange, P., & Vestbo, J. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00152205 · Cited by 150 · see citing works
Comorbidity of somatic chronic diseases and decline in physical functioning:
Kriegsman, D. M. W., Deeg, D. J. H., & Stalman, W. A. B. (2004) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00258-0 · Cited by 139 · see citing works
Lung function in type 2 diabetes: the Normative Aging Study
Litonjua, A. A., Lazarus, R. M., Sparrow, D., DeMolles, D., & Weiss, S. T. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.03.023 · Cited by 129 · see citing works
Muscle wasting in emphysema
Morrison, W. L., Gibson, J. N. A., Scrimgeour, C. M., & Rennie, M. J. (1988) · Clinical Science · doi:10.1042/cs0750415 · Cited by 123 · see citing works
Large-artery stiffness, hypertension and cardiovascular risk in older patients
Blacher, J., & Safar, M. E. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0307 · Cited by 121 · see citing works
Risk factors for community-acquired pneumonia diagnosed by general practitioners in the community
Farr, B. M., Woodhead, M. A., Macfarlane, J. T., Bartlett, C. L. R., MCCRACKEN, J. S., Wadsworth, J., & Miller, D. L. (2000) · Respiratory Medicine · doi:10.1053/rmed.1999.0743 · Cited by 113 · see citing works
Frequent Non-Cardiac Comorbidities in Patients with Chronic Heart Failure
Dahlström, U. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2005.01.008 · Cited by 113 · see citing works
The Future of Aging Therapies
Hadley, E. C., Lakatta, E. G., Morrison‐Bogorad, M., Warner, H. R., & Hodes, R. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.030 · Cited by 110 · see citing works
Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia
Huttunen, R., Laine, J., Lumio, J., Vuento, R., & Syrjänen, J. (2007) · BMC Infectious Diseases · doi:10.1186/1471-2334-7-13 · Cited by 102 · see citing works
Multifaceted roles of TNF‐α in myoblast destruction: A multitude of signal transduction pathways
Stewart, C. E., Newcomb, P. V., & Holly, J. M. P. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10387 · Cited by 99 · see citing works
Can Disease Management Target Patients Most Likely to Generate High Costs? The Impact of Comorbidity
Charlson, M. E., Charlson, R. E., Briggs, W. M., & Hollenberg, J. P. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0130-7 · Cited by 98 · see citing works
Characterization of T Lymphocytes in Chronic Obstructive Pulmonary Disease
Barnes, P. J., & Cosío, M. G. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010020 · Cited by 97 · see citing works
Effects of Noncardiovascular Comorbidities on Antihypertensive Use in Elderly Hypertensives
Wang, P. S., Avorn, J., Brookhart, M. A., Mogun, H., Schneeweiß, S., Fischer, M. A., & Glynn, R. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000172753.96583.e1 · Cited by 96 · see citing works
Total daily energy expenditure relative to resting energy expenditure in clinically stable patients with COPD
Baarends, E. M., Schols, A. M. W. J., Westerterp, K. R., & Wouters, E. F. �. (1997) · Thorax · doi:10.1136/thx.52.9.780 · Cited by 92 · see citing works
Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?
Koechlin‐Ramonatxo, C., Couillard, A., Cristol, J., Chanez, P., Hayot, M., GALLAIS, D. L., & Prefaut, C. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00069004 · Cited by 90 · see citing works
Epidemiology of Pulmonary Arterial Hypertension
Taichman, D. B., & Mandel, J. (2013) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2013.08.010 · Cited by 88 · see citing works
Nutritional and metabolic modulation in chronic obstructive pulmonary disease management
Schols, A. M. W. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004611 · Cited by 82 · see citing works
Impaired glucose tolerance in patients with chronic hypoxic pulmonary disease.
Hjalmarsen, A., Aasebø, U., Birkeland, K., Sager, G., & Jorde, R. (1996) · PubMed · Cited by 72 · see citing works
Emphysema detected by lung cancer screening with low‐dose spiral CT: Prevalence, and correlation with smoking habits and pulmonary function in Japanese male subjects
Omori, H., Nakashima, R., Otsuka, N., Mishima, Y., TOMIGUCHI, S., Narimatsu, A., Nonami, Y., 修一, 三., Koyama, W., Marubayashi, T., et al. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00827.x · Cited by 71 · see citing works
Preventing chronic disease: a priority for global health
Strong, K., Mathers, C. D., Epping‐Jordan, J. E., & Beaglehole, R. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyi315 · Cited by 71 · see citing works
The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue
(2000) · doi:10.1002/1096-9896(2000)9999:9999 · Cited by 70 · see citing works
The Activity of Cytochrome Oxidase Is Increased in Circulating Lymphocytes of Patients with Chronic Obstructive Pulmonary Disease, Asthma, and Chronic Arthritis
Sauleda, J., García-Palmer, F., GONZÁLEZ, G., Palou, A., & Agustí, A. G. N. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.1.9807079 · Cited by 65 · see citing works
Diet, obesity and diabetes: a current update
Walker, C. G., Zariwala, M. G., Holness, M. J., & Sugden, M. C. (2006) · Clinical Science · doi:10.1042/cs20060150 · Cited by 62 · see citing works
Thomas A. Neff Lecture. Chronic Obstructive Pulmonary Disease: A Systemic Disease
Agustí, A. G. N. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200603-058ms · Cited by 61 · see citing works
Pathogenesis of Bacterial Exacerbations of COPD
Veeramachaneni, S. B., & Sethi, S. (2006) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550600651347 · Cited by 59 · see citing works
Chronic obstructive pulmonary disease: effects beyond the lungs
Balasubramanian, V. P., & Varkey, B. (2006) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000208449.73101.ac · Cited by 57 · see citing works
Markers of Hemostasis and Systemic Inflammation in Heart Disease and Atherosclerosis in Smokers
MacCallum, P. K. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200406-036ms · Cited by 55 · see citing works
Raloxifene modulates interleukin-6 and tumor necrosis factor-alpha synthesis in vivo: results from a pilot clinical study.
Gianni, W., Ricci, A., Gazzaniga, P., Brama, M., Pietropaolo, M., Votano, S., Patané, F., Aglianó, A., Spera, G., Marigliano, V., et al. (2004) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2004-0795 · Cited by 55 · see citing works
Statins in the treatment of chronic heart failure: Biological and clinical considerations
van der Harst, P., Voors, A. A., van Gilst, W. H., Böhm, M., & VANVELDHUISEN, D. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.04.011 · Cited by 55 · see citing works
The Role of Systemic Corticosteroids in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Niewoehner, D. E. (2002) · American Journal of Respiratory Medicine · doi:10.1007/bf03256615 · Cited by 42 · see citing works
Predictive Role of Single Diseases and Their Combination on Recovery of Balance and Gait in Disabled Elderly Patients
Fazio, I. D., Franzoni, S., Frisoni, G. B., Gatti, S., Cornali, C., Stofler, P. M., & Trabucchi, M. (2006) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2005.12.008 · Cited by 41 · see citing works
Chronic obstructive pulmonary disease : A systemic disease
Agustí, A. G. N., & de Mallorca, P. (2006) · Proceedings of the American Thoracic Society · Cited by 39 · see citing works
Epidemiology of Pulmonary Arterial Hypertension
Taichman, D. B., & Mandel, J. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2006.11.012 · Cited by 39 · see citing works
Chronic disease in the elderly: back to the future of internal medicine
Fabbri, L. M., & Ferrari, R. (2006) · Breathe · doi:10.1183/18106838.0301.40 · Cited by 28 · see citing works
Prevalence and diagnosis of severe pulmonary hypertension in patients with chronic obstructive pulmonary disease
Mal, H. (2007) · Current Opinion in Internal Medicine · doi:10.1097/mcp.0b013e32801d217f · Cited by 25 · see citing works
Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients?
Sin, D. D., & Man, S. F. P. (2007) · Current Opinion in Internal Medicine · doi:10.1097/mcp.0b013e3280142021 · Cited by 23 · see citing works
Managing Elders With Comorbidities
Schraeder, C., Dworak, D., Stoll, J. F., Kucera, C. L., Waldschmidt, V., & Dworak, M. P. (2005) · Journal of Ambulatory Care Management · doi:10.1097/00004479-200507000-00003 · Cited by 21 · see citing works
Skeletal Muscles in Chronic Airflow Obstruction
Maltais, F. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2307007 · Cited by 13 · see citing works
Mortality rates for common respiratory diseases in an English population 1979-1998: artefact and substantive trends
Goldacre, M. J., Duncan, M., Cook, P. J., & Griffith, M. (2004) · Journal of Public Health · doi:10.1093/pubmed/fdh099 · Cited by 13 · see citing works
T Cells Cause Lung Damage in Emphysema
(2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010025 · Cited by 7 · see citing works
Infection and COPD.
Hogg, J. C. (2005) · PubMed · Cited by 6 · see citing works

Flagged first, then by citations

1 of the 139 references couldn’t be matched to a known paper.

Sorted by citations

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983 · see citing works
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary
Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187 · see citing works
“Hypertension is likely to be the most frequently occurring comorbidity in COPD and may have implications for prognosis.(308,324)”
BackgroundSelf-citation
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880 · see citing works
Systemic manifestations and comorbidities of COPD
Barnes, P. J., & Celli, B. R. (2009) · European Respiratory Journal · doi:10.1183/09031936.00128008 · Cited by 1,818 · see citing works
Comorbidities and Risk of Mortality in Patients with Chronic Obstructive Pulmonary Disease
Divo, M. J., Côté, C., de-Torres, J. P., Casanova, C., Marín, J. M., Pinto-Plata, V., Zulueta, J. J., Cabrera, C., Zagaceta, J., Hunninghake, G. M., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0034oc · Cited by 1,275 · see citing works
“Because the association with these other diseases seems to be stronger in patients with COPD than in patients without the disease (16), Fabbri and coworkers (31) proposed that perhaps COPD was just one more manifestation of a systemic inflammatory syndrome.”
Background
Chronic obstructive pulmonary disease
Decramer, M., Janssens, W., & Miravitlles, M. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60968-9 · Cited by 975 · see citing works
“73, 74 No randomised controlled trials have yet been done to investigate whether treatment with broncho dilators or inhaled corticosteroids reduces the prevalence or severity of comorbidities.”
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
Vogelmeier, C. F., Criner, G. J., Martínez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.00214-2017 · Cited by 885 · see citing works
Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Lung Disease 2017 Report
Vogelmeier, C. F., Criner, G. J., Martínez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · Respirology · doi:10.1111/resp.13012 · Cited by 684 · see citing works
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
Vogelmeier, C. F., Criner, G. J., Martínez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2017.02.001 · Cited by 758 · see citing works
Comorbidities of COPD
Cavailles, A., Brinchault-Rabin, G., Dixmier, A., Goupil, F., Gut‐Gobert, C., Marchand-Adam, S., Meurice, J.-C., Morel, H., Person-Tacnet, C., Leroyer, C., et al. (2013) · European Respiratory Review · doi:10.1183/09059180.00008612 · Cited by 524 · see citing works
Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial
Vestbo, J., Anderson, J. A., Brook, R. D., Calverley, P. M. A., Celli, B. R., Crim, C. C., Martínez, F. J., Yates, J., & Newby, D. E. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30069-1 · Cited by 483 · see citing works
The clinical and economic burden of chronic obstructive pulmonary disease in the USA
Ray, S. M., Guarascio, Finch, C. K., & Self, T. (2013) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s34321 · Cited by 430 · see citing works
“COPD is rarely seen in isolation but rather is often managed with comorbidities including heart failure, lung cancer, diabetes, hypertension, and dyslipidemia.(8) Systemic inflammation likely plays a key role in the development of these concomitant disease states, and elevated biomarkers such as C-reactive protein are…”
Background
Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study
Postma, D. S., Brightling, C. E., Baldi, S., van den Berge, M., Fabbri, L. M., Gagnatelli, A., Papi, A. A., van der Molen, T., Rabe, K. F., Siddiqui, S., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30049-9 · Cited by 409 · see citing works
Prediction of the Clinical Course of Chronic Obstructive Pulmonary Disease, Using the New GOLD Classification: A Study of the General Population
Lange, P., Marott, J. L., Vestbo, J., Olsen, K. R., Ingebrigtsen, T. S., Dahl, M., & Nordestgaard, B. G. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1299oc · Cited by 365 · see citing works
Chronic renal failure: a neglected comorbidity of COPD.
Incalzi, R., Corsonello, A., Pedone, C., Battaglia, S., Paglino, G., & Bellia, V. (2010) · Chest · doi:10.1378/chest.09-1710 · Cited by 378 · see citing works
Determinants of Depression in the ECLIPSE Chronic Obstructive Pulmonary Disease Cohort
Hanania, N. A., Müllerová, H., Locantore, N., Vestbo, J., Watkins, M. L., Wouters, E. F. �., Rennard, S. I., & Sharafkhaneh, A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0472oc · Cited by 321 · see citing works
Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study
McDonnell, M. J., Aliberti, S., Goeminne, P., Restrepo, M. I., Finch, S., Pesci, A., Dupont, L., Fardon, T. C., Wilson, R., Loebinger, M. R., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)30320-4 · Cited by 318 · see citing works
Informe 2017 de la Iniciativa Global para el Diagnóstico, Tratamiento y Prevención de la Enfermedad Pulmonar Obstructiva Crónica: Resumen Ejecutivo de GOLD
Vogelmeier, C. F., Criner, G. J., Martínez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2017.02.001 · Cited by 311 · see citing works
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. What We Know and Can Do for Our Patients
Jaitovich, A., & Barreiro, E. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201710-2140ci · Cited by 310 · see citing works
“diabetes, cancer, and/or other conditions associated with different causes of muscle dysfunction (30).”
Background
COPD and multimorbidity: Recognising and addressing a syndemic occurrence
Fabbri, L. M., Celli, B. R., Agustí, A., Criner, G. J., Dransfield, M. T., Divo, M., Krishnan, J. K., Lahousse, L., Montes de Oca, M., Salvi, S. S., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00261-8 · Cited by 274 · see citing works
Self-citation
The Metabolic Syndrome in Patients With Chronic Bronchitis and COPD
Watz, H., Waschki, B., Kirsten, A., Müller, K.-C., Kretschmar, G., Meyer, T., Holz, O., & MAGNUSSEN, H. (2009) · CHEST Journal · doi:10.1378/chest.09-0393 · Cited by 268 · see citing works
Early chronic obstructive pulmonary disease: definition, assessment, and prevention
Rennard, S. I., & Drummond, M. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60647-x · Cited by 265 · see citing works
Managing comorbidities in COPD
Tzanakis, Ν., Hillas, G., Perlikos, F., & Tsiligianni, I. (2015) · International Journal of COPD · doi:10.2147/copd.s54473 · Cited by 251 · see citing works
“68 71 Diabetes worsens the outcomes of COPD by affecting a number of parameters: 66,72,73 shortening time to first hospitalization and increasing hospitalization time and risk of death during exacerbations, 74 increasing Medical Research Council dyspnea scores, and reducing six-minute walking…”
Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea
McNicholas, W. T. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0347pp · Cited by 249 · see citing works
Systemic Manifestations of COPD
Nussbaumer‐Ochsner, Y., & Rabe, K. F. (2011) · CHEST Journal · doi:10.1378/chest.10-1252 · Cited by 245 · see citing works
Inflammatory Biomarkers and Comorbidities in Chronic Obstructive Pulmonary Disease
Thomsen, M., Dahl, M., Lange, P., Vestbo, J., & Nordestgaard, B. G. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-1113oc · Cited by 239 · see citing works
Comorbidities and Short-term Prognosis in Patients Hospitalized for Acute Exacerbation of COPD
Almagro, P., Cabrera, F. J., Díez‐Manglano, J., Boixeda, R., Ortiz, M. B. A., Murio, C., & Soriano, J. B. (2012) · CHEST Journal · doi:10.1378/chest.11-2413 · Cited by 242 · see citing works
Prevalence of Comorbidities in Patients with Chronic Obstructive Pulmonary Disease
Cazzola, M., Bettoncelli, G., Sessa, E., Cricelli, C. A., & Biscione, G. L. (2010) · Respiration · doi:10.1159/000281880 · Cited by 226 · see citing works
Comorbidities, Patient Knowledge, and Disease Management in a National Sample of Patients with COPD
Barr, R. G., Celli, B. R., Mannino, D. M., Petty, T. L., Rennard, S. I., Sciurba, F. C., Stoller, J. K., Thomashow, B. M., & Turino, G. M. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.09.042 · Cited by 223 · see citing works
COPD-OSA Overlap Syndrome
McNicholas, W. T. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.04.160 · Cited by 208 · see citing works
Diabetes and Lung Disease: An Underestimated Relationship
Khateeb, J., Fuchs, E., & Khamaisi, M. (2019) · The Review of Diabetic Studies · doi:10.1900/rds.2019.15.1 · Cited by 200 · see citing works
CPAP and survival in moderate-to-severe obstructive sleep apnoea syndrome and hypoxaemic COPD
Machado, M.-C. L., Vollmer, W. M., Togeiro, S. M., Bilderback, A. L., Oliveira, M.-V. C., Leitão, F. S., Queiroga, F., Lorenzi‐Filho, G., & Krishnan, J. A. (2009) · European Respiratory Journal · doi:10.1183/09031936.00192008 · Cited by 196 · see citing works
Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk
Guerra, S., Sherrill, D., Venker, C., Ceccato, C. M., Halonen, M. J., & Martinez, F. D. (2009) · Thorax · doi:10.1136/thx.2008.110619 · Cited by 193 · see citing works
“There is now convincing evidence that in COPD airway inflammation may extend beyond the lung to systemic inflammation(14-20), which, in turn, has been implicated in the systemic manifestations and excess mortality risk of this disease(21).”
Background
Airflow Limitation in Smokers Is Associated with Subclinical Atherosclerosis
Iwamoto, H., Yokoyama, A., Kitahara, Y., Ishikawa, N., Haruta, Y., Yamane, K., Hattori, N., Hara, H., & Kohno, N. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-560oc · Cited by 189 · see citing works
Heart failure and chronic obstructive pulmonary disease: the challenges facing physicians and health services
Hawkins, N. M., Virani, S., & Ceconi, C. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht192 · Cited by 186 · see citing works
Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies
Chan, S. M. H., Selemidis, S., Bozinovski, S., & Vlahos, R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.013 · Cited by 183 · see citing works
“Moreover, continued systemic inflammation promotes the formation of atherosclerotic plaques, giving rise to cardiovascular comorbidity in COPD patients (Fabbri et al., 2008; Mizuno, Jacob, & Mason, 2011).”
Background
The Diabetic Lung - A New Target Organ?
Pitocco, D., Fuso, L., Conte, E. G., Zaccardi, F., Condoluci, C., Scavone, G., Incalzi, R. A., & Ghirlanda, G. (2012) · The Review of Diabetic Studies · doi:10.1900/rds.2012.9.23 · Cited by 178 · see citing works
“Thus, both systemic and pulmonary inflammation may be implicated in the complex interplay between respiratory and metabolic dysfunction [20].”
Background
COPD uncovered: an international survey on the impact of chronic obstructive pulmonary disease [COPD] on a working age population
Fletcher, M. J., Upton, J., Taylor-Fishwick, J. C., Buist, S. A., Jenkins, C. R., Hutton, J., Barnes, N. C., van der Molen, T., Walsh, J. W., Jones, P., et al. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-612 · Cited by 156 · see citing works
“It is recognised that comorbid diseases commonly occur with COPD [9-11].”
Background
The Diagnosis and Treatment of COPD and Its Comorbidities.
Kahnert, K., Jörres, R. A., Behr, J., & Welte, T. (2023) · PubMed Central · doi:10.3238/arztebl.m2023.027 · Cited by 145 · see citing works
Should We View Chronic Obstructive Pulmonary Disease Differently after ECLIPSE?. A Clinical Perspective from the Study Team
Vestbo, J., Agustí, A. G. N., Wouters, E. F. �., Bakke, P. S., Calverley, P. M. A., Celli, B. R., Coxson, H. O., Crim, C. C., Edwards, L. D., Locantore, N., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201311-2006pp · Cited by 142 · see citing works
Chronic obstructive pulmonary disease and cerebrovascular disease: A comprehensive review
Lahousse, L., Tiemeier, H. W., Ikram, M. A., & Brusselle, G. (2015) · Respiratory Medicine · doi:10.1016/j.rmed.2015.07.014 · Cited by 136 · see citing works
A Postmortem Analysis of Major Causes of Early Death in Patients Hospitalized With COPD Exacerbation
Zvezdin, B., Milutinov, S., Vukoja, M. K., Hadnadjev, M., Hromiš, S., Marković, M., & Gajic, O. (2009) · CHEST Journal · doi:10.1378/chest.08-2918 · Cited by 136 · see citing works
COPD: early diagnosis and treatment to slow disease progression
Welte, T., Vogelmeier, C. F., & Papi, A. A. (2014) · International Journal of Clinical Practice · doi:10.1111/ijcp.12522 · Cited by 134 · see citing works
Web-based Health Information Seeking and eHealth Literacy among Patients Living with Chronic Obstructive Pulmonary Disease (COPD)
Stellefson, M., Shuster, J. J., Chaney, B. H., Paige, S. R., Alber, J. M., Chaney, J. D., & Sriram, P. (2017) · Health Communication · doi:10.1080/10410236.2017.1353868 · Cited by 132 · see citing works
Impact of comorbidities on COPD-specific health-related quality of life
Burgel, P., Escamilla, R., Perez, T., Carré, P., Caillaud, D. M., Chanez, P., Pinet, C., Jébrak, G., Brinchault, G., Court‐Fortune, I., et al. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.10.002 · Cited by 128 · see citing works
Efficacy of standard rehabilitation in COPD outpatients with comorbidities
Crisafulli, E., Gorgone, P., Vagaggini, B., Pagani, M., Rossi, G., Costa, F., Guarriello, V., Paggiaro, P., Chetta, A. A., Blasio, F. D., et al. (2010) · European Respiratory Journal · doi:10.1183/09031936.00203809 · Cited by 127 · see citing works
“So far, it has been pointed out that Chronic Obstructive Pulmonary Disease (COPD), a common disease in the older population, is often associated with co-morbidities (5-8), sharing systemic pathological features with some of them (6,9).”
Background
An Official American Thoracic Society Workshop Report: The Integrated Care of the COPD Patient
Nici, L. L., & ZuWallack, R. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-014st · Cited by 126 · see citing works
“Their concept of proactive integrated care included four interventions: (1) disease-specific education, (2) teaching selfmanagement strategies, (3) enhanced communication with study coordinators, and (4) remote home monitoring.”
BackgroundMethodInfluential
Asthma and comorbid medical illness
Cazzola, M., Calzetta, L., Bettoncelli, G., Novelli, L., Cricelli, C. A., & Rogliani, P. (2010) · European Respiratory Journal · doi:10.1183/09031936.00140310 · Cited by 123 · see citing works
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
MacNee, W. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370819 · Cited by 119 · see citing works
Water-based exercise in COPD with physical comorbidities: a randomised controlled trial
McNamara, R. J., McKeough, Z. J., McKenzie, D. K., & Alison, J. A. (2012) · European Respiratory Journal · doi:10.1183/09031936.00034312 · Cited by 123 · see citing works
Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD
Al-shair, K., Kolsum, U., Dockry, R., Morris, J., Singh, D., & Vestbo, J. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-3 · Cited by 118 · see citing works
“It has been suggested that systemic manifestations may be related to systemic inflammation in COPD [2,3].”
Background
Treatment of COPD: the sooner the better?
Decramer, M., & Cooper, C. B. (2010) · Thorax · doi:10.1136/thx.2009.133355 · Cited by 114 · see citing works
In-Hospital and One-Year Mortality and Their Predictors in Patients Hospitalized for First-Ever Chronic Obstructive Pulmonary Disease Exacerbations: A Nationwide Population-Based Study
Ho, T., Tsai, Y., Ruan, S., Huang, C., Lai, F., Yu, C., & The HINT Study Group (2014) · PLoS ONE · doi:10.1371/journal.pone.0114866 · Cited by 115 · see citing works
“[1, 27] Angiotensin II receptor blockers, b blockers and statins are commonly used therapeutic drug classes in the management of cardiovascular patients and many trials have demonstrated their protective effects on cardiovascular outcomes.”
Background
Comorbidities and Burden of COPD: A Population Based Case-Control Study
Baty, F., Putora, P. M., Isenring, B. D., Blum, T. G., & Brutsche, M. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063285 · Cited by 109 · see citing works
Cardiovascular disease in asthma and COPD: A population-based retrospective cross-sectional study
Cazzola, M., Calzetta, L., Bettoncelli, G., Cricelli, C. A., Romeo, F., Matera, M. G., & Rogliani, P. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.07.021 · Cited by 109 · see citing works
Airflow obstruction and metabolic syndrome: the Guangzhou Biobank Cohort Study
Lam, H. K. B., Jordan, R. E., Jiang, C. Q., Thomas, G. N., Miller, M. R., Zhang, W. S., Lam, T., Cheng, K. K., & Adab, P. (2009) · European Respiratory Journal · doi:10.1183/09031936.00024709 · Cited by 109 · see citing works
“At present most chronic conditions are managed according to clinical guidelines that were designed to cater for the specific needs of individual diseases with little reference to multimorbidity [1, 2].”
Background
Myocardial infarction and other co-morbidities in patients with chronic obstructive pulmonary disease: a Danish Nationwide Study of 7.4 million individuals
Sode, B. F., Dahl, M., & Nordestgaard, B. G. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr338 · Cited by 108 · see citing works
“However, there are different alternative suggestions as to the cause for association between chronic obstructive pulmonary disease and its co-morbidities, including inflammation.(1,12) –15 For myocardial infarction, the likely explanation of the life-time association with chronic obstructive pulmonary disease is commo…”
Background
Risk factors and comorbidities in the preclinical stages of chronic obstructive pulmonary disease.
van Remoortel, H., Hornikx, M., Langer, D., Burtin, C., Everaerts, S., Verhamme, P., Boonen, S., Gosselink, R., Decramer, M., Troosters, T., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201307-1240oc · Cited by 122 · see citing works
The Interplay Between Immune Response and Bacterial Infection in COPD: Focus Upon Non-typeable Haemophilus influenzae
Su, Y.-C., Jalalvand, F., Thegerström, J., & Riesbeck, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02530 · Cited by 107 · see citing works
“Although COPD mainly affects the lungs, it also produces significant extrapulmonary consequences as a results of an escalated inflammatory response orchestrated by airway cells and immune mediators (20, 21).”
Background
Characteristics and Prognosis of Never-Smokers and Smokers with Asthma in the Copenhagen General Population Study: A Prospective Cohort Study
Çolak, Y., Afzal, S., Nordestgaard, B. G., & Lange, P. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201502-0302oc · Cited by 104 · see citing works
FAQs about the GOLD 2011 assessment proposal of COPD: a comparative analysis of four different cohorts
Agustí, A. G. N., Hurd, S. S., Jones, P., Fabbri, L. M., Martínez, F. J., Vogelmeier, C. F., Vestbo, J., & Rodriguez‐Roisin, R. (2013) · European Respiratory Journal · doi:10.1183/09031936.00036513 · Cited by 103 · see citing works
Psoriasis and chronic obstructive pulmonary disease: a case-control study
Dreiher, J., Weitzman, D., Shapiro, J. S., Davidovici, B. B., & Cohen, A. D. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08749.x · Cited by 102 · see citing works
Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease
Viglino, D., Jullian‐Desayes, I., Minovès, M., Aron‐Wisnewsky, J., Leroy, V., Zarski, J., Tamisier, R., Joyeux‐Faure, M., & Pépin, J. (2017) · European Respiratory Journal · doi:10.1183/13993003.01923-2016 · Cited by 98 · see citing works
Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease
Perez, T., Burgel, P., Paillasseur, J.-L., Caillaud, D. M., Deslée, G., Chanez, P., & Roche, N. (2015) · International Journal of COPD · doi:10.2147/copd.s82408 · Cited by 101 · see citing works
“For example, high rates of cardiovascular diseases (eg, chronic heart failure) and mood disorders (eg, anxiety and depression) have been reported in COPD patients 5,6 and suggested as contributing to dyspnea.”
Comorbidities and Systemic Effects of Chronic Obstructive Pulmonary Disease
Choudhury, G., Rabinovich, R., & MacNee, W. (2014) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2013.10.007 · Cited by 100 · see citing works
“Patients with COPD often have 1 or more components of the metabolic syndrome,(228) which are, at least in part, independent of treatment with steroids and/or physical inactivity.(229) Comorbidities and Systemic Effects of COPD 117”
Depression Is Associated with Readmission for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Iyer, A. S., Bhatt, S. P., Garner, J. J., Wells, J. M., Trevor, J. L., Patel, N. M., Kirkpatrick, D., Williams, J. C., & Dransfield, M. T. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201507-439oc · Cited by 95 · see citing works
Earlier diagnosis and earlier treatment of COPD in primary care
Price, D. B., Freeman, D., Cleland, J., Kaplan, A. G., & Cerasoli, F. (2010) · Primary Care Respiratory Journal · doi:10.4104/pcrj.2010.00060 · Cited by 94 · see citing works
The Study to Understand Mortality and Morbidity in COPD (SUMMIT) study protocol
Vestbo, J., Anderson, J. A., Brook, R. D., Calverley, P. M. A., Celli, B. R., Crim, C. C., Haumann, B., Martínez, F. J., Yates, J., & Newby, D. E. (2012) · European Respiratory Journal · doi:10.1183/09031936.00087312 · Cited by 91 · see citing works
“It is increasingly recognized that COPD often coexists with other chronic diseases and that comorbidities can contribute to patients’ health status and prognosis [2, 3].”
Background
Recognition, diagnosis, and treatment of cognitive and psychiatric disorders in patients with COPD
Ouellette, D. R., & Lavoie, K. (2017) · International Journal of COPD · doi:10.2147/copd.s123994 · Cited by 87 · see citing works
“Patients with COPD are more likely to have coronary artery disease,(8,10) lung cancer,(11,12) metabolic syndrome,(13,14) osteoporosis,(15,16) diabetes mellitus,(8,17) and hypertension(8,18) than persons without COPD, resulting in some suggesting COPD be considered a multisystem inflammatory disorder rather than a cond…”
Influential
Muscle and Blood Redox Status after Exercise Training in Severe COPD Patients
Rodriguez, D. A., Kalko, S., Puig-Vilanova, E., Perez-Olabarría, M., Falciani, F., Gea, J., Cascante, M., Barreiro, E., & Roca, J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.022 · Cited by 102 · see citing works
Multidimensional assessment of older people with asthma and COPD: clinical management and health status
McDonald, V. M., Simpson, J. L., Higgins, I. J., & Gibson, P. G. (2010) · Age and Ageing · doi:10.1093/ageing/afq134 · Cited by 88 · see citing works
Endothelial Dysfunction and Specific Inflammation in Obesity Hypoventilation Syndrome
Borel, J., Roux‐Lombard, P., Tamisier, R., Arnaud, C., Monneret, D., Arnol, N., Baguet, J.-P., Levy, P. A., & Pépin, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006733 · Cited by 84 · see citing works
“Not only obesity but many other systemic diseases like diabetes, COPD, cardiovascular diseases or sleep apnea are associated with an underlying pro-inflammatory state [8,29,30].”
Background
COPD – do the right thing
Sandelowsky, H., Weinreich, U. M., Aarli, B. B., Sundh, J., Høines, K. J., Stratelis, G., Løkke, A., Janson, C., Jensen, C., & Larsson, K. (2021) · BMC Family Practice · doi:10.1186/s12875-021-01583-w · Cited by 83 · see citing works
“age, smoking, systemic inflammation) or by one disease increasing the risk severity of the other [18, 141].”
Background
Systemic Inflammation in Chronic Obstructive Pulmonary Disease and Asthma: Relation with Comorbidities
MAGNUSSEN, H., & Watz, H. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200906-053dp · Cited by 80 · see citing works
“The question arises whether systemic inflammation is the result of a spill-over of local inflammation to the systemic compartment or whether systemic inflammation might be a systemic component of COPD not necessarily related to the local inflammatory processes in the lung (2, 15, 16).”
Background
Coronary artery disease concomitant with chronic obstructive pulmonary disease
Roversi, S., Roversi, P., Spadafora, G., Rossi, R., & Fabbri, L. M. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12181 · Cited by 81 · see citing works
Increased Sympathetic Nerve Activity in COPD is Associated with Morbidity and Mortality
Andreas, S., Haarmann, H., Klarner, S. F., Hasenfuss, G. P., & Raupach, T. (2013) · Lung · doi:10.1007/s00408-013-9544-7 · Cited by 79 · see citing works
“Although COPD primarily affects the lungs, it has recently become clear that systemic effects of COPD significantly contribute to its severity and overall mortality [1, 4].”
Background
Biomarkers in chronic obstructive pulmonary disease
Rosenberg, S. R., & Kalhan, R. (2012) · Translational research · doi:10.1016/j.trsl.2012.01.019 · Cited by 77 · see citing works
Controversies in treatment of chronic obstructive pulmonary disease
Rabe, K. F., & Wedzicha, J. A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61295-6 · Cited by 76 · see citing works
Identification of Clinical Phenotypes Using Cluster Analyses in COPD Patients with Multiple Comorbidities
Burgel, P., Paillasseur, J.-L., & Roche, N. (2014) · BioMed Research International · doi:10.1155/2014/420134 · Cited by 76 · see citing works
“, diabetes, dyslipidemia, and metabolic syndrome), and cancer have been found highly prevalent among COPD patients [5, 6].”
Background
Why Does Lung Function Predict Mortality? Results From the Whitehall II Cohort Study
Sabia, S., Shipley, M. J., Elbaz, A., Marmot, M. G., Mika Kivimaki, B., Kauffmann, F., & Singh‐Manoux, A. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq294 · Cited by 76 · see citing works
Validity and Responsiveness of the Depression Anxiety Stress Scales-21 (DASS-21) in COPD
Yohannes, A. M., Dryden, S., & Hanania, N. A. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.12.010 · Cited by 79 · see citing works
Network medicine, multimorbidity and the lung in the elderly
Faner, R., Cruz, T., López-Giraldo, A., & Agustí, A. G. N. (2014) · European Respiratory Journal · doi:10.1183/09031936.00078714 · Cited by 73 · see citing works
Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD
Koskela, J. T., Kilpeläinen, M., Kupiainen, H., Mazur, W., Sintonen, H., Boezen, M., Lindqvist, A. E., Postma, D. S., & Laitinen, T. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-102 · Cited by 73 · see citing works
“and addiction diseases [1-5].”
The cardiopulmonary continuum systemic inflammation as ‘common soil’ of heart and lung disease
Ukena, C., Mahfoud, F., Kindermann, M., Kindermann, I., Bals, R., Voors, A. A., van Veldhuisen, D. J., & Böhm, M. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.04.082 · Cited by 73 · see citing works
Involvement of Endothelial Apoptosis Underlying Chronic Obstructive Pulmonary Disease–like Phenotype in Adiponectin-null Mice: Implications for Therapy
Nakanishi, K., Takeda, Y., Tetsumoto, S., Iwasaki, T., Tsujino, K., Kuhara, H., Jin, Y., Nagatomo, I., Kida, H., Goya, S., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201007-1091oc · Cited by 72 · see citing works
Electrocardiographic abnormalities and cardiac arrhythmias in chronic obstructive pulmonary disease
Goudis, C. A., Konstantinidis, A. K., Ntalas, I. V., & Korantzopoulos, P. G. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.096 · Cited by 72 · see citing works
“Thus, cardiovascular and pulmonary risk factors create a “cardiopulmonary continuum” through shared systemic inflammatory processes, inducing cascades of events which underpin chronic diseases including COPD, CAD, and HF [84,85].”
Background
Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model
Lüthje, L., Raupach, T., Michels, H., Unsöld, B. W., Hasenfuss, G. P., Kögler, H., & Andreas, S. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-7 · Cited by 72 · see citing works
“Although COPD affects primarily the lungs it recently became clear that systemic effects of COPD significantly contribute to its severity and mortality [1,6].”
Background
Natural Histories of Chronic Obstructive Pulmonary Disease
Rennard, S. I., & Vestbo, J. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200804-035qc · Cited by 72 · see citing works
The diagnosis and treatment of COPD and its comorbidities
Kahnert, K., Jörres, R. A., Behr, J., & Welte, T. (2023) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2023.0027 · Cited by 204 · see citing works
Clinical relevance of plasma miR-106b levels in patients with chronic obstructive pulmonary disease
Soeda, S., Ohyashiki, J. H., Ohtsuki, K., Umezu, T., Setoguchi, Y., & Ohyashiki, K. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1251 · Cited by 70 · see citing works
d-dimer as a Prognostic Biomarker for Mortality in Chronic Obstructive Pulmonary Disease Exacerbation
Fruchter, O., Yigla, M., & Kramer, M. R. (2014) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000332 · Cited by 70 · see citing works
How to Integrate Multiple Comorbidities in Guideline Development: Article 10 in Integrating and Coordinating Efforts in COPD Guideline Development. An Official ATS/ERS Workshop Report
Fabbri, L. M., Boyd, C. M., Boschetto, P., Rabe, K. F., Buist, A. S., Yawn, B. P., Leff, B. A., Kent, D. M., & Schünemann, H. J. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201208-063st · Cited by 70 · see citing works
Dietary nitrate supplementation in COPD: An acute, double-blind, randomized, placebo-controlled, crossover trial
Kerley, C. P., Cahill, K., Bolger, K., McGowan, A., Burke, C., Faul, J., & Cormican, L. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.12.010 · Cited by 69 · see citing works
Malnutrition according to ESPEN consensus predicts hospitalizations and long-term mortality in rehabilitation patients with stable chronic obstructive pulmonary disease
Marco, E., Sánchez‐Rodríguez, D., Dávalos‐Yerovi, V., Durán, X., Pascual, E. M., Muniesa, J. M., Rodriguez, D. A., Aguilera-Zubizarreta, A., Escalada, F., & Duarte, E. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.014 · Cited by 69 · see citing works
COPD and the metabolic syndrome: an intriguing association
Clini, E. M., Crisafulli, E., Radaeli, A., & Malerba, M. (2011) · Internal and Emergency Medicine · doi:10.1007/s11739-011-0700-x · Cited by 67 · see citing works
“decade, however, it has been increasingly recognized that the presence of common factors in COPD and in other chronic extra-pulmonary diseases, together with the frequent co-existence of these conditions in the same adult individual, supports the hypothesis of a common process sharing their pathogenesis in the same pa…”
Background
B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review
Hawkins, N. M., Khosla, A., Virani, S., McMurray, J. J. V., & FitzGerald, J. M. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-016-0345-7 · Cited by 67 · see citing works
“Many of these factors are present in stable COPD and common non-infective precipitants of exacerbation [32, 41, 63].”
Background
Comorbidity in chronic obstructive pulmonary disease
Negewo, N. A., McDonald, V. M., & Gibson, P. G. (2015) · Respiratory Investigation · doi:10.1016/j.resinv.2015.02.004 · Cited by 66 · see citing works
“Clinical decision making is further complicated by the lack of adequate recommendations in the existing guidelines regarding the management of COPD patients, who may also suffer from other comorbid conditions [103].”
Background
Management of the COPD Patient with Comorbidities: An Experts Recommendation Document
Iglesias, J. R., Díez‐Manglano, J., Garcı́a, F. L., Peromingo, J. A. D., Almagro, P., & Aguilar, J. M. V. (2020) · International Journal of COPD · doi:10.2147/copd.s242009 · Cited by 74 · see citing works
Potential benefits of statins on morbidity and mortality in chronic obstructive pulmonary disease: a review of the evidence
Young, R. P., Hopkins, R. J., & Eaton, T. E. (2009) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.078477 · Cited by 64 · see citing works
Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients
Ställberg, B., Janson, C., Larsson, K., Johansson, G. S., Κostikas, Κ., Gruenberger, J.-B., Gutzwiller, F. S., Jørgensen, L., Uhde, M., & Lisspers, K. (2018) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-018-0101-y · Cited by 64 · see citing works

Chronic obstructive disease and comorbidities (literature review)
Stavila, E., Botnaru, V., Rusu, D., & Corlăteanu, A. (2021) · Bulletin of the Academy of Sciences of Moldova Medical Sciences · doi:10.52692/1857-0011.2021.1-69.33 · Cited by 2 · see citing works
Systemic manifestations and comorbidities of COPD
Barnes, P. J., & Celli, B. R. (2009) · European Respiratory Journal · doi:10.1183/09031936.00128008 · Cited by 1,818 · see citing works
The Emerging Role of Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Tran, B. T., & Kalhan, R. (2008) · Clinical Pulmonary Medicine · doi:10.1097/cpm.0b013e3181671a46 · Cited by 4 · see citing works
Systemic Manifestations and Comorbidities of Chronic Obstructive Pulmonary Disease
Most, J. F., Possick, J. D., & Rochester, C. L. (2014) · Clinical Pulmonary Medicine · doi:10.1097/cpm.0000000000000044 · Cited by 3 · see citing works
Systemic inflammatory biomarkers and co-morbidities of chronic obstructive pulmonary disease
MacNee, W. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.732703 · Cited by 123 · see citing works

Authors: Fabbri, L. M., Luppi, F., Beghé, B., & Rabe, K. F.
Affiliations: University of Modena and Reggio Emilia (IT)
ORCID: Fabbri, L. M.
Luppi, F.
Beghé, B.
Rabe, K. F.
Venue: European Respiratory Journal
Publisher: European Respiratory Society (ERS)
Published: 2007-12-31
Volume: 31
Issue: 1
Pages: 204-212
ISSN: 0903-1936 (ISSN-L)
1399-3003
DOI: 10.1183/09031936.00114307
OpenAlex: W2165340553
Cited by: 660
References: 139
Citations by year: 2026: 8 · 2025: 16 · 2024: 20 · 2023: 17 · 2022: 26 · 2021: 19 · 2020: 35 · 2019: 25 · 2018: 36 · 2017: 48 · 2016: 31 · 2015: 50 · 2014: 68 · 2013: 55 · 2012: 59
FWCI: 28.24
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
Locations: European Respiratory Journal (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: chronic obstructive pulmonary disease, comorbidities, systemic inflammation, chronic heart failure, metabolic syndrome, cigarette smoking, C-reactive protein, inflammatory markers, COPD severity assessment, cardiovascular function, COPD management
MeSH terms: Chronic Disease, Health Status, Humans, Inflammation, Lung, Models, Biological, Prognosis, Risk Factors, Smoking, Pulmonary Medicine, Comorbidity, Guidelines as Topic, Pulmonary Disease, Chronic Obstructive, Overweight

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Complex chronic comorbidities of COPD

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks