The DOI matches its Crossref record; 144 of the 146 references it cites were found in a registry or an index.
Male hypogonadism
Abstract
Male hypogonadism is a clinical syndrome that results from failure to produce physiological concentrations of testosterone, normal amounts of sperm, or both. Hypogonadism may arise from testicular disease (primary hypogonadism) or dysfunction of the hypothalamic-pituitary unit (secondary hypogonadism). Clinical presentations vary dependent on the time of onset of androgen deficiency, whether the defect is in testosterone production or spermatogenesis, associated genetic factors, or history of androgen therapy. The clinical diagnosis of hypogonadism is made on the basis of signs and symptoms consistent with androgen deficiency and low morning testosterone concentrations in serum on multiple occasions. Several testosterone-replacement therapies are approved for treatment and should be selected according to the patient's preference, cost, availability, and formulation-specific properties. Contraindications to testosterone-replacement therapy include prostate and breast cancers, uncontrolled congestive heart failure, severe lower-urinary-tract symptoms, and erythrocytosis. Treatment should be monitored for benefits and adverse effects.
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In the citing paper
“Elevated follicle-stimulating hormone levels in the setting of testosterone deficiency (hypergonadatropic hypogonadism) is typically indicative of impaired spermatogenesis”
From Evaluation and Management of Testosterone Deficiency: AUA Guideline (2018) · cites this paper as [6]
In the citing paper
“These androgens are, during the male life span, needed to promote masculine development/virilization and growth, and are of vital importance in reproductive functioning [166].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [166]
In the citing paper
“Manifesting differently between male individuals, symptoms of androgen deficiency vary according to age of onset, severity of T deficiency, androgen sensitivity and previous and/or current use of T replacement therapy [166].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [166]
Citations
Cites
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Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
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Identification of late-onset hypogonadism in middle-aged and elderly men
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Adverse Events Associated with Testosterone Administration
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Self-citationAndrogen Receptor Defects: Historical, Clinical, and Molecular Perspectives*
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Advances in Male Contraception
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The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
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Cited by
Sorted by citations
Evaluation and Management of Testosterone Deficiency: AUA Guideline
Mulhall, J. P., Trost, L. W., Brannigan, R. E., Kurtz, E. G., Redmon, J. B., Chiles, K. A., Lightner, D. J., Miner, M. M., Murad, M. H., Nelson, C. J., et al. (2018) · Journal of Urology · doi:10.1016/j.juro.2018.03.115 · Cited by 766
Clinical Management of Congenital Hypogonadotropic Hypogonadism
Young, J., Xu, C., Papadakis, G. E., Acierno, J. S., Maione, L., Hietamäki, J., Raivio, T., & Pitteloud, N. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00116 · Cited by 425
Clocchiatti, A., Cora, E., Zhang, Y., & Dotto, G. P. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.30 · Cited by 372
Klinefelter Syndrome: Integrating Genetics, Neuropsychology, and Endocrinology
Gravholt, C. H., Chang, S., Wallentin, M., Fedder, J., Moore, P. J., & Skakkebaek, A. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00212 · Cited by 354
Skinner, R., Mulder, R. L., Kremer, L. C. M., Hudson, M. M., Constine, L. S., Bárdi, E., Boekhout, A. H., Borgmann‐Staudt, A., Brown, M. C., Cohn, R. J., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30026-8 · Cited by 240
Metadata
- Authors
- Basaria, S.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Basaria, Shehzad
- ORCID
- Basaria, Shehzad
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 383
- Issue
- 9924
- Pages
- 1250-1263
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4211201846
- Cited by
- 328
- References
- 146
- Citations by year
- 2026: 24 · 2025: 30 · 2024: 38 · 2023: 33 · 2022: 45 · 2021: 30 · 2020: 33 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 17 · 2015: 14 · 2014: 9
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- male hypogonadism, androgen deficiency, hypergonadotropic hypogonadism, secondary hypogonadism, testosterone replacement therapy, spermatogenesis, hypothalamic-pituitary dysfunction, testicular diseases, diagnosis, treatment monitoring, contraindications
- MeSH terms
- Contraindications, Administration, Cutaneous, Administration, Oral, Affect, Androgens, Cardiovascular Diseases, Cognition Disorders, Diabetes Mellitus, Gels, Humans, Hypogonadism, Hypothalamo-Hypophyseal System, Insulin Resistance, Lipids, Male, Polycythemia, Prostatic Neoplasms, Quality of Life, Sexual Dysfunction, Physiological, Sleep Apnea Syndromes, Tablets, Testis, Testosterone, Bone Density, Patient Satisfaction, Early Diagnosis, Muscle Strength
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