The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Human schistosomiasis
Open accessAbstract
Human schistosomiasis—or bilharzia—is a parasitic disease caused by trematode flukes of the genus Schistosoma. By conservative estimates, at least 230 million people worldwide are infected with Schistosoma spp. Adult schistosome worms colonise human blood vessels for years, successfully evading the immune system while excreting hundreds to thousands of eggs daily, which must either leave the body in excreta or become trapped in nearby tissues. Trapped eggs induce a distinct immune-mediated granulomatous response that causes local and systemic pathological effects ranging from anaemia, growth stunting, impaired cognition, and decreased physical fitness, to organ-specific effects such as severe hepatosplenism, periportal fibrosis with portal hypertension, and urogenital inflammation and scarring. At present, preventive public health measures in endemic regions consist of treatment once every 1 or 2 years with the isoquinolinone drug, praziquantel, to suppress morbidity. In some locations, elimination of transmission is now the goal; however, more sensitive diagnostics are needed in both the field and clinics, and integrated environmental and health-care management will be needed to ensure elimination.
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Cites
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291
Self-citationNemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Gurarie, D., Wang, X., Bustinduy, A. L., & King, C. H. (2011) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2011.10-0642 · Cited by 43
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Grimes, J. E. T., Croll, D., Harrison, W. E., Utzinger, J., Freeman, M. C., & Templeton, M. R. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003296 · Cited by 296
Ezeamama, A. E., Bustinduy, A. L., Nkwata, A. K., Martinez, L., Pabalan, N., Boivin, M. J., & King, C. H. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005524 · Cited by 149
Wang, L., Li, Z., Shen, J., Liu, Z., Liang, J., Wu, X., Sun, X., & Wu, Z. (2015) · Parasitology Research · doi:10.1007/s00436-015-4373-7 · Cited by 124
Metadata
- Authors
- Colley, D. G., Bustinduy, A. L., Secor, W. E., & King, C. H.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 383
- Issue
- 9936
- Pages
- 2253-2264
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4211071799
- Cited by
- 2,444
- References
- 3
- FWCI
- 94.90
- Type
- journal article
- Language
- en
- Open access
- green
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