Barriers and enablers of locally led clinical trials in Ethiopia and Cameroon: a prospective, qualitative study
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Four articles reported that the presence of unskilled authorities in the review process posed a barrier to conducting clinical trials.
“Four articles reported that the presence of unskilled authorities in the review process posed a barrier to conducting clinical trials [42, 45, 48, 49].”
From Barriers for conducting clinical trials in developing countries—A systematic review (2018) · cites this paper as [49]
Over-complex and unreasonably strict ethical and regulatory systems were reported in some articles.
“Over-complex and unreasonably strict ethical and regulatory systems were also reported in some articles [48, 49, 51].”
From Barriers for conducting clinical trials in developing countries—A systematic review (2018) · cites this paper as [49]
Delays in regulatory and ethical review were mentioned in most articles.
“Delays in regulatory and ethical review were mentioned in most articles [40, 42, 45, 46, 48, 49, 52].”
From Barriers for conducting clinical trials in developing countries—A systematic review (2018) · cites this paper as [49]
Absence of suitable research infrastructure was stated by many articles.
“Absence of suitable research infrastructure was stated by many articles [45, 47–50].”
From Barriers for conducting clinical trials in developing countries—A systematic review (2018) · cites this paper as [49]
Cited by
Sorted by citations
Barriers for conducting clinical trials in developing countries—A systematic review
Alemayehu, C., Mitchell, G., & Nikles, J. (2018) · International Journal for Equity in Health · doi:10.1186/s12939-018-0748-6 · Cited by 406 · see citing works
“Delays in regulatory and ethical review were mentioned in most articles [40, 42, 45, 46, 48, 49, 52].”
BackgroundInfluentialYang, M., An, Q., Ding, T., et al. (2017) · Annals of Operations Research · doi:10.1007/s10479-017-2682-1 · Cited by 39 · see citing works
Regulatory changes after the enforcement of the new Clinical Trials Act in Japan
Nakamura, K., & Shibata, T. (2020) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyaa028 · Cited by 39 · see citing works
Faay, M. D. M., Czobor, P., & Sommer, I. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0161-2 · Cited by 30 · see citing works
Parks, M. J., Kingsbury, J. H., Boyle, R. G., et al. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.05.019 · Cited by 30 · see citing works
Connecting low-income smokers to tobacco treatment services
Slater, J. S., Nelson, C. L., Parks, M. J., & Ebbert, J. O. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2015.10.013 · Cited by 17 · see citing works
International Clinical Trial Day and clinical trials in Ethiopia and Africa
Fekadu, A., Teferra, S., Hailu, A., Gebre‐Mariam, T., Addissie, A., Deressa, W. A., Yimer, G., & Reja, A. (2014) · Trials · doi:10.1186/1745-6215-15-493 · Cited by 14 · see citing works
“Local evidence is essential and is more likely to influence policy and practice [22,23].”
BackgroundN-of-1 trials in the clinical care of patients in developing countries: a systematic review
Alemayehu, C. M., Nikles, J., & Mitchell, G. K. (2018) · Trials · doi:10.1186/s13063-018-2596-5 · Cited by 7 · see citing works
“Moreover, the barriers already documented to conducting clinical trials in developing countries [37, 57, 58] and the specific barriers reported for implementing N-of-1 trials in developed countries (physicians’ time, physicians’ acceptance, drug companies’ acceptance, patient willingness, and cost”
BackgroundParks, M. J., Hughes, K. D., Keller, P. A., Lachter, R. B., Kingsbury, J. H., Nelson, C. L., & Slater, J. S. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2019.105867 · Cited by 5 · see citing works
Randomised clinical trials in surgery: are we at a crossroads?
Ramchurn, T. P., & Nundy, S. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001457 · Cited by 6 · see citing works
CURRENT STATUS OF CLINICAL TRIALS IN ETHIOPIA: HOW MUCH IS DONE?
Deressa, B. T., Rauch, D., Badra, E. V., Glatzer, M., Jeremic, B. M., Lössl, K., Igrutinovic, I., & Cihoric, N. (2018) · Ethiopian Medical Journal · doi:10.7892/boris.123938 · Cited by 4 · see citing works
“This results in inadequate locally-obtained evidence for clinical practice which in turn leads to adoption of the “developed world’s”- clinical practice standards and guidelines which may not be relevant or even harmful (9,10).”
BackgroundMwamwitwa, K. W., Munishi, C. G., Makoye, P. M., Maganga, A., Chambiri, S. M., Nyondo, G. G., Mlugu, E. M., Mwalwisi, Y. H., Oriyo, N. M., Ally, M. S., et al. (2026) · Therapeutic Innovation & Regulatory Science · doi:10.1007/s43441-026-00973-5 · Cited by 1 · see citing works
CLARION CALL FOR MORE CLINICAL TRIALS: THE CASE OF ETHIOPIA
Lulseged, S., & Aseffa, A. (2018) · Ethiopian Medical Journal
- Authors
- Franzen, S. R. P., Chandler, C., Atashili, J., Angus, B., & Lang, T.
- Affiliations
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- University of Buea (CM)
- Corresponding author
- Franzen, Samuel R P
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 382
- Pages
- 14
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2018652326
- Cited by
- 13
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Surgery
- Keywords
- investigator-initiated trials, barriers to clinical trials, research capacity building, research regulation, research incentives, research environment, low-income countries, Ethiopia, Cameroon, international research collaboration, researcher motivation
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