Rethinking the war on cancer
Open accessAbstract
Some 40 years ago a metaphor was posed that cancer was such an insidious adversary that a declaration of war on the disease was justified. Although this statement was a useful inspiration for enlistment of resources, despite extraordinary progress in our understanding of disease pathogenesis, in most cases and for most forms of cancer this war has not been won. A second metaphor was about magic bullets--targeted therapies based on knowledge of mechanisms that were envisaged to strike with devastating consequences for the disease. The reality, however, is that targeted therapies are generally not curative or even enduringly effective, because of the adaptive and evasive resistance strategies developed by cancers under attack. In this Series paper, I suggest that, much like in modern warfare, the war on cancer needs to have a battlespace vision.
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In the clinic, the persister state most closely corresponds to minimal residual disease from which relapse can occur if treatment is discontinued or if acquired drug resistance develops in response to continuous therapy.
“In the clinic, the persister state most closely corresponds to minimal residual disease from which relapse can occur if treatment is discontinued or if acquired drug resistance develops in response to continuous therapy.”
From Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer (2021) · cites this paper as [28]
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- Authors
- Hanahan, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Hanahan, Douglas
- ORCID
- Hanahan, Douglas
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 383
- Issue
- 9916
- Pages
- 558-563
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2098627399
- Cited by
- 271
- References
- 29
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 16 · 2021: 26 · 2020: 20 · 2019: 20 · 2018: 25 · 2017: 26 · 2016: 31 · 2015: 35 · 2014: 24 · 2013: 1 · 2012: 2
- FWCI
- 36.57
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Science, Research, and Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- war on cancer, cancer, targeted therapy, drug resistance, adaptive resistance, carcinogenesis, cancer treatment strategies
- MeSH terms
- Antineoplastic Agents, Health Planning, Humans, Neoplasms, Anticarcinogenic Agents, Metaphor, Molecular Targeted Therapy
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