Cited by 271Science, Research, and MedicineCancer Genomics and DiagnosticsCancer Cells and Metastasis

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Rethinking the war on cancer

Open access

Hanahan, Douglas·2014·The Lancet

Open this paper in CoChat — free account

Abstract

Some 40 years ago a metaphor was posed that cancer was such an insidious adversary that a declaration of war on the disease was justified. Although this statement was a useful inspiration for enlistment of resources, despite extraordinary progress in our understanding of disease pathogenesis, in most cases and for most forms of cancer this war has not been won. A second metaphor was about magic bullets--targeted therapies based on knowledge of mechanisms that were envisaged to strike with devastating consequences for the disease. The reality, however, is that targeted therapies are generally not curative or even enduringly effective, because of the adaptive and evasive resistance strategies developed by cancers under attack. In this Series paper, I suggest that, much like in modern warfare, the war on cancer needs to have a battlespace vision.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(13)62226-6

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Self-citation
The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Self-citation
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632
Self-citation
Nivolumab plus Ipilimumab in Advanced Melanoma
Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230
Modes of resistance to anti-angiogenic therapy
Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953
Self-citation
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
Flaherty, K. T., Infante, J. R., Daud, A., Gonzalez, R., Kefford, R. F., Sosman, J., Hamid, O., Schuchter, L., Cebon, J., Ibrahim, N., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1210093 · Cited by 2,810
Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
Coussens, L. M., Zitvogel, L., & Palucka, A. K. (2013) · Science · doi:10.1126/science.1232227 · Cited by 1,096
Combinatorial drug therapy for cancer in the post-genomic era
Al-Lazikani, B., Banerji, U., & Workman, P. (2012) · Nature Biotechnology · doi:10.1038/nbt.2284 · Cited by 1,070
Economic burden of cancer across the European Union: a population-based cost analysis
Luengo-Fernández, R., Leal, J., Gray, A. M., & Sullivan, R. J. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70442-x · Cited by 1,055
Cancer heterogeneity: implications for targeted therapeutics
Fisher, R. A., Pusztai, L., & Swanton, C. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.581 · Cited by 972

Show all 29 references

Sorted by citations

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
Fitzmaurice, C., Allen, C., Barber, R. M., Barregård, L., Bhutta, Z. A., Brenner, H., Dicker, D., Chimed‐Ochir, O., Dandona, R., Dandona, L., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5688 · Cited by 6,318
The great escape: tumour cell plasticity in resistance to targeted therapy
Boumahdi, S., & de Sauvage, F. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0044-1 · Cited by 785
New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment
Chen, S., & Chang, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174136 · Cited by 443
Designing a broad-spectrum integrative approach for cancer prevention and treatment
Block, K. I., Gyllenhaal, C., Lowe, L. J., Amedei, A., Amin, A. R. M. R., Amin, A., Aquilano, K., Arbiser, J. L., Arreola, A., Arzumanyan, A. L., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.09.007 · Cited by 308
Emerging role of tumor cell plasticity in modifying therapeutic response
Qin, S., Jiang, J., Lü, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 289
DrugComb: an integrative cancer drug combination data portal
Zagidullin, B., Aldahdooh, J., Zheng, S., Wang, W., Wang, Y., Saad, J. J., Malyutina, A., Jafari, M., Tanoli, Z., Pessia, A., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz337 · Cited by 270
Hallmarks of cancer—Then and now, and beyond
Hanahan, D. (2026) · Cell · doi:10.1016/j.cell.2025.12.049 · Cited by 314
Self-citation
Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
Sethi, G., Shanmugam, M. K., Warrier, S. R., Mérarchi, M., Arfuso, F., Kumar, A. P., & Bishayee, A. (2018) · Nutrients · doi:10.3390/nu10050645 · Cited by 254
Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
Poornima, P., Kumar, J. D., Zhao, Q., Blunder, M., & Efferth, T. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.06.018 · Cited by 254
Stem cell-based therapies for cancer treatment: separating hope from hype
Stuckey, D. W., & Shah, K. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3798 · Cited by 225
Managing critically Ill hematology patients: Time to think differently
Azoulay, É., Pène, F., Darmon, M., Lengliné, É., Benoît, D., Soares, M., Vincent, F., Bruneel, F., Perez, P., Lemiale, V., et al. (2015) · Blood Reviews · doi:10.1016/j.blre.2015.04.002 · Cited by 217
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment
Wu, P., Gao, W. Q., Su, M., Nice, E. C., Zhang, W., Lin, J., & Xie, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641469 · Cited by 218
Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer
Malyutina, A., Majumder, M. M., Wang, W., Pessia, A., Heckman, C. A., & Tang, J. P. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006752 · Cited by 207
Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer
Cabanos, H. F., & Hata, A. N. (2021) · Cancers · doi:10.3390/cancers13112666 · Cited by 189
Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development
Jo, Y., Choi, N., Kim, K., Koo, H., Choi, J. H., & Kim, H. N. (2018) · Theranostics · doi:10.7150/thno.29098 · Cited by 188
Modulating inflammation for cancer therapy
Ritter, B., & Greten, F. R. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181739 · Cited by 162
Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells
Fan, K., Li, X., Cao, Y., Qi, H., Li, L., Zhang, Q., & Sun, H. (2015) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000263 · Cited by 155
Carcinogenesis explained within the context of a theory of organisms
Sonnenschein, C., & Soto, A. M. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.07.004 · Cited by 137
Frequency of BRAF V600E mutations in 969 central nervous system neoplasms
Behling, F., Barrantes‐Freer, A., Skardelly, M., Nieser, M., Christians, A., Stockhammer, F., Rohde, V., Tatagiba, M. S., Hartmann, C. J., Stadelmann, C., et al. (2016) · Diagnostic Pathology · doi:10.1186/s13000-016-0506-2 · Cited by 112
Protecting the normal in order to better kill the cancer
Liu, B., Ezeogu, L., Zellmer, L., Yu, B., Xu, N., & Liao, D. J. (2015) · Cancer Medicine · doi:10.1002/cam4.488 · Cited by 111
Programmed death ligand‐1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder
Wang, B., Pan, W., Yang, M., Yang, W., He, W., Chen, X., Bi, J., Jiang, N., Huang, J., & Lin, T. (2018) · Cancer Science · doi:10.1111/cas.13887 · Cited by 96
Tumor and the Microenvironment: A Chance to Reframe the Paradigm of Carcinogenesis?
Bizzarri, M., & Cucina, A. (2014) · BioMed Research International · doi:10.1155/2014/934038 · Cited by 93
Invasion and metastasis: the elusive hallmark of cancer
Meirson, T., Gil-Henn, H., & Samson, A. O. (2019) · Oncogene · doi:10.1038/s41388-019-1110-1 · Cited by 91
Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors
Neul, C., Schaeffeler, E., Sparreboom, A., Laufer, S., Schwab, M. G., & Nies, A. T. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.08.003 · Cited by 93
Over a century of cancer research: Inconvenient truths and promising leads
Sonnenschein, C., & Soto, A. M. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000670 · Cited by 90
The “virgin birth”, polyploidy, and the origin of cancer
Erenpreisa, J. A., Salmiņa, K., Huna, A., Jackson, T., Vázquez‐Martín, A., & Cragg, M. S. (2014) · Oncoscience · doi:10.18632/oncoscience.108 · Cited by 83
Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression
Brohée, L., Peulen, O., Nusgens, B., Castronovo, V., Thiry, M., Colige, A., & Deroanne, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-25340-9 · Cited by 81
Mesenchymal stem/stromal cells: Developmental origin, tumorigenesis and translational cancer therapeutics
Li, C., Zhao, H., & Wang, B. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100948 · Cited by 77
Burden of early, advanced and metastatic breast cancer in The Netherlands
Vondeling, G. T., Menezes, G. L. G., Dvortsin, E., Jansman, F. G. A., Konings, I. R. H. M., Postma, M. J., & Rozenbaum, M. H. (2018) · BMC Cancer · doi:10.1186/s12885-018-4158-3 · Cited by 72
Derivatization Strategy for Simultaneous Molecular Imaging of Phospholipids and Low-Abundance Free Fatty Acids in Thyroid Cancer Tissue Sections
Wang, S., Wang, Y.-J., Zhang, J., Sun, T., & Guo, Y. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05680 · Cited by 73
Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities
Chin, V. T., Nagrial, A. M., Chou, A. S. Y., Biankin, A. V., Gill, A. J., Timpson, P., & Pajic, M. (2015) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2015.17 · Cited by 71
Membrane-core nanoparticles for cancer nanomedicine
Guo, J., & Huang, L. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.05.005 · Cited by 69
The oncolytic virusdl922-947 reduces IL-8/CXCL8 and MCP-1/CCL2 expression and impairs angiogenesis and macrophage infiltration in anaplastic thyroid carcinoma
Passaro, C., Borriello, F., Vastolo, V., Somma, S. D., Scamardella, E., Gigantino, V., Franco, R., Marone, G., & Portella, G. (2015) · Oncotarget · doi:10.18632/oncotarget.6430 · Cited by 68
Tumor cell-intrinsic phenotypic plasticity facilitates adaptive cellular reprogramming driving acquired drug resistance
Hammerlindl, H., & Schaider, H. (2017) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-017-0435-1 · Cited by 70
The Reverse Transcriptase Encoded by LINE-1 Retrotransposons in the Genesis, Progression, and Therapy of Cancer
Sciamanna, I., Luca, C. D., & Spadafora, C. (2016) · Frontiers in Chemistry · doi:10.3389/fchem.2016.00006 · Cited by 66
Anticancer potential of Trigonella foenum graecum: Cellular and molecular targets
Bairi, K. E., Ouzir, M., Najda, A., & Khalki, L. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.071 · Cited by 63
One more chemo or one too many? Defining the limits of treatment and innovation in medical oncology
Baszanger, I. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2012.03.023 · Cited by 62
Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance
de Klerk, D. J., Honeywell, R. J., Jansen, G., & Peters, G. J. (2018) · Cancers · doi:10.3390/cancers10120503 · Cited by 62
Invasion and Metastasis as a Central Hallmark of Breast Cancer
Saha, T., Solomon, J., Samson, A. O., & Gil-Henn, H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163498 · Cited by 59
Biological Hallmarks of Cancer
Hanahan, D., & Weinberg, R. A. (2017) · Wiley eBooks · doi:10.1002/9781119000822.hfcm002 · Cited by 64
Self-citation
Cancer associated fibroblast: Mediators of tumorigenesis
Alexander, J. I., & Cukierman, E. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.05.004 · Cited by 55
Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions
Zhang, J., Lou, X., Jin, L., Zhou, R., Liu, S., Xu, N., & Liao, D. J. (2014) · Oncoscience · doi:10.18632/oncoscience.61 · Cited by 53
Personalized targeted therapy for esophageal squamous cell carcinoma
Kang, X. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7648 · Cited by 54
Doxorubicin-loaded polypeptide nanorods based on electrostatic interactions for cancer therapy
Zhang, L., Zhang, P., Zhao, Q., Zhang, Y., Cao, L., & Luan, Y. (2015) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2015.11.008 · Cited by 51
Improving Bioprinted Volumetric Tumor Microenvironments In Vitro
Li, ., Parra‐Cantu, C., Wang, Z., & Zhang, Y. S. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.06.002 · Cited by 51
Droplet Array-Based 3D Coculture System for High-Throughput Tumor Angiogenesis Assay
Du, X., Li, W., Du, G.-S., Cho, H., Yu, M., Fang, Q., Lee, L. P., & Jin, F. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04772 · Cited by 50
The other side of the coin: The tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND–CDK4/6–RB axis
Lou, X., Zhang, J., Liu, S., Lou, X., & Liao, D. J. (2014) · Cell Cycle · doi:10.4161/cc.29082 · Cited by 50
Colorectal tumor 3Din vitromodels: advantages of biofabrication for the recapitulation of early stages of tumour development
Rosa, J. M. R. D. L., Wubetu, J., Tirelli, N., & Tirella, A. (2018) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/aac1c9 · Cited by 49
Secoiridoids of olive and derivatives as potential coadjuvant drugs in cancer: A critical analysis of experimental studies
Celano, M., Maggisano, V., Lepore, S. M., Russo, D., & Bulotta, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.045 · Cited by 47
“Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients
Xu, K., Chen, J., Kong, X., Lv, Y., Qin, S.-C., Sun, X., Mu, F., & Lu, T. (2019) · Medical Gas Research · doi:10.4103/2045-9912.266985 · Cited by 47
IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.
Lin, Y.-W., Weng, X., Huang, B.-L., Guo, H., Xu, Y., & Peng, Y. (2021) · PubMed Central · Cited by 45
Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms
Lyubitelev, A. V., & Studitsky, V. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310663 · Cited by 53
A Metabolomic Approach to Predict Breast Cancer Behavior and Chemotherapy Response
Cardoso, M. R., Santos, J. C., Ribeiro, M. L., Talarico, M., Viana, L. R., & Derchain, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020617 · Cited by 44
A Holistic Model of Care to Support Those Living with and beyond Cancer
Cadet, T. J., Davis, C., Elks, J., & Wilson, P. A. (2016) · Healthcare · doi:10.3390/healthcare4040088 · Cited by 44
Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids?
Loh, J. S., Tan, L., Lee, W.-L., Ming, L. C., How, C. W., Foo, J. B., Kifli, N., Goh, B. H., & Ong, Y. S. (2021) · Cancers · doi:10.3390/cancers13215346 · Cited by 42
Prediction of drug cocktail effects when the number of measurements is limited
Zimmer, A., Tendler, A., Katzir, I., Mayo, A., & Alon, U. S. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002518 · Cited by 39
Testing alternative regression models to predict utilities: mapping the QLQ-C30 onto the EQ-5D-5L and the SF-6D
Lamu, A. N., & Olsen, J. A. (2018) · Quality of Life Research · doi:10.1007/s11136-018-1981-6 · Cited by 38
Emergence and impact of theranostic‐nanoformulation of triple therapeutics for combination cancer therapy
Rajora, A. K., Ahire, E. D., Rajora, M. A. K., Singh, S., Bhattacharya, J., & Zhang, H. (2024) · Smart Medicine · doi:10.1002/smmd.20230035 · Cited by 39
Pharmacogenomics and targeted therapy of cancer: Focusing on non-small cell lung cancer
Haghgoo, S. M., Allameh, A., Mortaz, E., Garssen, J., Folkerts, G., Barnes, P. J., & Adcock, I. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.029 · Cited by 39
On waiting, hauntings and surviving: Chronicling life with cancer through solicited diaries
Broom, A. F., Kenny, K., & Kirby, E. R. (2017) · The Sociological Review · doi:10.1177/0038026117719216 · Cited by 38
Chasing Mendel: five questions for personalized medicine
Joyner, M. J., & Prendergast, F. G. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.272336 · Cited by 38
Implementing successful systematic Patient Reported Outcome and Experience Measures (PROMs and PREMs) in robotic oncological surgery—The role of physicians
Lungu, D. A., Pennucci, F., Rosis, S. D., Romano, G., & Melfi, F. M. A. (2019) · The International Journal of Health Planning and Management · doi:10.1002/hpm.2959 · Cited by 36
Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
Madia, V. N., Nicolai, A., Messore, A., Leo, A. D., Ialongo, D., Tudino, V., Saccoliti, F., Vita, D. D., Scipione, L., Artico, M., et al. (2021) · Molecules · doi:10.3390/molecules26030771 · Cited by 36
Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii
Lun, Z., Lai, D., Wen, Y., Zheng, L., Shen, J.-L., Yang, T.-B., Zhou, W., Qu, L., Hide, G., & Ayala, F. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502599112 · Cited by 39
The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?
de Assis, L. V. M., Moraes, M. N., & Castrucci, A. M. D. L. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03183-5 · Cited by 33
Modeling the Leukemia Microenviroment In Vitro
Scielzo, C., & Ghia, P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.607608 · Cited by 35
The 50-Year War on Cancer Revisited: Should We Continue to Fight the Enemy Within?
Surh, Y.-J. (2021) · Journal of Cancer Prevention · doi:10.15430/jcp.2021.26.4.219 · Cited by 33
An investigation of bacteriocin nisin anti-cancer effects and FZD7 protein interactions in liver cancer cells
Balçık-Erçin, P., & Sever, B. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110152 · Cited by 33
Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics
Erenpreisa, J. A., & Giuliani, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010240 · Cited by 32
Two-dimensional (2D) hybrid nanomaterials for diagnosis and treatment of cancer
Ashfaq, M., Talreja, N., Chauhan, D., Afreen, S., Sultana, A., & Srituravanich, W. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103268 · Cited by 31
Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy
Platt, J. L., Zhou, X., Lefferts, A. R., & Cascalho, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071118 · Cited by 31
SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms
Bizzarri, M., & Cucina, A. (2016) · Acta Biotheoretica · doi:10.1007/s10441-016-9281-4 · Cited by 31
Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines
Skowron, M. A., Niegisch, G., Fritz, G., Arent, T., van Roermund, J. G. H., Romano, A., Albers, P., Schulz, W. A., & Hoffmann, M. J. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0259-x · Cited by 29
Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression
Sciamanna, I., Gualtieri, A., Piazza, P. V., & Spadafora, C. (2014) · Oncotarget · doi:10.18632/oncotarget.2504 · Cited by 29
Targeting drug‐tolerant cells: A promising strategy for overcoming acquired drug resistance in cancer cells
Song, X.-H., Yang, L., Zheng, X., Zhu, Q., Liao, X.-L., Liu, K., Zhang, W., Peng, Q., Zhu, Y., Zhao, L.-Y., et al. (2023) · MedComm · doi:10.1002/mco2.342 · Cited by 28
Tweeting About Prostate and Testicular Cancers: What Are Individuals Saying in Their Discussions About the 2013 Movember Canada Campaign?
Bravo, C. A., & Hoffman‐Goetz, L. (2015) · Journal of Cancer Education · doi:10.1007/s13187-015-0838-8 · Cited by 28
Cancer Metastases: So Close and So Far
Sonnenschein, C., & Soto, A. M. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv236 · Cited by 31
Expression Characteristics and Significant Diagnostic and Prognostic Values of ANLN in Human Cancers
Ahmad, M., Khan, M., Rizwan, A., Sial, N., Abid, U., Shamim, T., Hameed, Z., Iqbal, M. J., Sarfraz, U., Saeed, H., et al. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s343975 · Cited by 27
Complement and the hallmarks of cancer
Artero, M. R., Minery, A., Nedelcev, L., Radanova, M. A., & Roumenina, L. T. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101950 · Cited by 30
Novel biomarkers in cancer: The whole is greater than the sum of its parts
Samatov, T. R., Galatenko, V., Block, A., Shkurnikov, M. Y., Tonevitsky, A., & Schumacher, U. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.09.002 · Cited by 26
The War on Cancer: Lessons from the War on Terror
Huang, S. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00293 · Cited by 25
Vasculature Disruption Enhances Bacterial Targeting of Autochthonous Tumors
Drees, J. J., Mertensotto, M. J., Augustin, L. B., Schottel, J. L., & Saltzman, D. A. (2015) · Journal of Cancer · doi:10.7150/jca.12491 · Cited by 24
Multi-label Deep Learning for Gene Function Annotation in Cancer Pathways
Guan, R., Wang, X., Yang, M. Q., Zhang, Y. L., Zhou, F., Yang, C., & Liang, Y. (2018) · Scientific Reports · doi:10.1038/s41598-017-17842-9 · Cited by 24
The Adaptive and Innate Immune Cell Landscape of Uterine Leiomyosarcomas
Manzoni, M., Bolognesi, M. M., Antoranz, A., Mancari, R., Carinelli, S. G., Faretta, M., Bosisio, F. M., & Cattoretti, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-57627-1 · Cited by 24
The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice
Cao, M., Royce, D. B., Risingsong, R., Williams, C. R., Sporn, M. B., & Liby, K. T. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0325 · Cited by 23
Opportunities and Challenges for Antibodies against Intracellular Antigens
Yang, X., Xie, S., Yang, X., Jumbo, J. C. C., Hou, X., Tang, Z., Yao, H., Mo, F., Yin, S., Liu, A., et al. (2019) · Theranostics · doi:10.7150/thno.35486 · Cited by 22
Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma
Zomerman, W. W., Plasschaert, S. L. A., Conroy, S., Scherpen, F. J. G., Boer, T. M.-D., Lourens, H. J., Llobet, S. G., Smit, M. J., Slagter‐Menkema, L., Seitz, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.089 · Cited by 22
Immunotherapy of melanoma: efficacy and mode of action
Wieder, T., Brenner, E., Braumüller, H., & Röcken, M. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12819 · Cited by 22
Illness and heroics: On counter-narrative and counter‑metaphor in the discourse on cancer
Hansen, P. K. (2018) · Frontiers of Narrative Studies · doi:10.1515/fns-2018-0039 · Cited by 21
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells
Meireles, D. R. P., Fernandes, H., Wanderley, T. L. R., Batista, T. M., Mangueira, V. M., de Sousa, T. K. G., Pita, J. C. L. R., Xavier, A. L., Beltrão, D. M., Tavares, J. F., et al. (2016) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2016.05.014 · Cited by 21
Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling
Dong, J., Aulestia, F. J., Kahn, S. A., Zeniou, M., Dubois, L. G., El-Habr, E. A., Daubeuf, F., Tounsi, N., Cheshier, S. H., Frossard, N., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.01.010 · Cited by 21
An Epigenetic LINE-1-Based Mechanism in Cancer
Lavia, P., Sciamanna, I., & Spadafora, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314610 · Cited by 21
The war on cancer: time for a new terminology
Haines, I. E. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60907-7 · Cited by 20
Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue—Going Beyond Apoptosis Induction
Heudobler, D., Lüke, F., Vogelhuber, M., Klobuch, S., Pukrop, T., Herr, W., Gerner, C., Pantziarka, P., Ghibelli, L., & Reichle, A. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01408 · Cited by 20
Using Metaphors to Explain Molecular Testing to Cancer Patients
Pinheiro, A. P. M., Pocock, R. H., Dixon, M. D., Shaib, W. L., Ramalingam, S. S., & Pentz, R. D. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0270 · Cited by 19
Inducing Controlled Release and Increased Tumor-Targeted Delivery of Chlorambucil via Albumin/Liposome Hybrid Nanoparticles
Zhang, Q., Zhang, L., Li, Z., Xie, X., Gao, X., & Xu, X. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0782-5 · Cited by 19
Changing the Paradigm of Cancer Screening, Prevention, and Treatment
Doss, M. (2016) · Dose-Response · doi:10.1177/1559325816680539 · Cited by 19
The Penrose Effect and its acceleration by the war on drugs: a crisis of untranslated neuroscience and untreated addiction and mental illness
Grecco, G. G., & Chambers, R. A. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0661-9 · Cited by 18
A pH-responsive supramolecular hydrogel encapsulating a CuMnS nanoenzyme catalyst for synergistic photothermal–photodynamic–chemodynamic therapy of tumours
Dong, A., Huang, S., Qian, Z., Xu, S., Yuan, W., & Wang, B. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01769a · Cited by 18
Targeted inhibition of WRN helicase, replication stress and cancer
Orlovetskie, N., Serruya, R., Abboud-Jarrous, G., & Jarrous, N. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.11.004 · Cited by 18

Authors: Hanahan, D.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Hanahan, Douglas
ORCID: Hanahan, Douglas
Venue: The Lancet
Publisher: Elsevier BV
Published: 2014-02
Volume: 383
Issue: 9916
Pages: 558-563
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(13)62226-6
OpenAlex: W2098627399
Cited by: 271
References: 29
Citations by year: 2026: 10 · 2025: 9 · 2024: 10 · 2023: 16 · 2022: 16 · 2021: 26 · 2020: 20 · 2019: 20 · 2018: 25 · 2017: 26 · 2016: 31 · 2015: 35 · 2014: 24
FWCI: 36.57
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Science, Research, and Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: war on cancer, cancer, targeted therapy, drug resistance, adaptive resistance, carcinogenesis, cancer treatment strategies
MeSH terms: Antineoplastic Agents, Health Planning, Humans, Neoplasms, Anticarcinogenic Agents, Metaphor, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Rethinking the war on cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks