Hanahan, Douglas

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 66,590

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell

Cancer Cells and MetastasisCancer Genomics and Diagnostics

Cited by 29,219

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

Hanahan, D., & Folkman, J. (1996) · Cell

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 6,885

The consensus molecular subtypes of colorectal cancer

Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine

Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancer

Cited by 5,170

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell

Cancer Cells and MetastasisImmune cells in cancer

Cited by 4,632

Modes of resistance to anti-angiogenic therapy

Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 2,953

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology

Angiogenesis and VEGF in CancerProtease and Inhibitor Mechanisms

Cited by 2,797

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., et al. (2011) · Nature Medicine

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 1,967

Induction of angiogenesis during the transition from hyperplasia to neoplasia

Folkman, J., Watson, K., Ingber, D., & Hanahan, D. (1989) · Nature

Angiogenesis and VEGF in CancerPancreatic function and diabetes

Cited by 1,879

Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors

Casanovas, O., Hicklin, D. J., Bergers, G., & Hanahan, D. (2005) · Cancer Cell

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 1,621

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell

Immune cells in cancerTGF-β signaling in diseases

Cited by 1,515

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell

Protease and Inhibitor MechanismsImmune cells in cancer

Cited by 1,306

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

Bergers, G., Javaherian, K., Lo, K.-M., Folkman, J., & Hanahan, D. (1999) · Science

Angiogenesis and VEGF in CancerMathematical Biology Tumor Growth

Cited by 988

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

Sadanandam, A., Lyssiotis, C. A., Homicsko, K., Collisson, E. A., Gibb, W. J., Wullschleger, S., Ostos, L. C. G., Lannon, W. A., Grotzinger, C., Del Rio, M., et al. (2013) · Nature Medicine

Colorectal Cancer Treatments and StudiesGene expression and cancer classification

Cited by 960

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

Coussens, L. M., Raymond, W. W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G. H., & Hanahan, D. (1999) · Genes & Development

Angiogenesis and VEGF in CancerMast cells and histamine

Cited by 946

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

Allen, E., Jabouille, A., Rivera, L. B., Lodewijckx, I., Missiaen, R., Steri, V., Feyen, K., Tawney, J., Hanahan, D., Michael, I. P., et al. (2017) · Science Translational Medicine

Cancer Immunotherapy and BiomarkersAngiogenesis and VEGF in Cancer

Cited by 820

An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

Giraudo, E., Inoue, M., & Hanahan, D. (2004) · Journal of Clinical Investigation

Angiogenesis and VEGF in CancerProtease and Inhibitor Mechanisms

Cited by 700

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development

Pancreatic and Hepatic Oncology ResearchTGF-β signaling in diseases

Cited by 674

Synaptic proximity enables NMDAR signalling to promote brain metastasis

Zeng, Q., Michael, I. P., Zhang, P., Saghafinia, S., Knott, G., Jiao, W., McCabe, B. D., Galván, J. A., Robinson, H. P. C., Zlobec, I., et al. (2019) · Nature

Brain Metastases and TreatmentNeuroscience and Neuropharmacology Research

Cited by 574

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas

Hodgson, G., Hager, J. H., Volik, S., Hariono, S., Wernick, M., Moore, D., Albertson, D. G., Pinkel, D., Collins, C., Hanahan, D., et al. (2001) · Nature Genetics

Genomic variations and chromosomal abnormalitiesPancreatic function and diabetes

Cited by 294

Cellular Transformation and Malignancy Induced by ras Require c-jun

Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 282

Rethinking the war on cancer

Hanahan, D. (2014) · The Lancet

Science, Research, and MedicineCancer Genomics and Diagnostics

Cited by 271

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

Ulanet, D. B., Ludwig, D. L., Kahn, C. R., & Hanahan, D. (2010) · Proceedings of the National Academy of Sciences

Growth Hormone and Insulin-like Growth FactorsMetabolism, Diabetes, and Cancer

Cited by 235

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

Allen, E., Miéville, P., Warren, C. M., Saghafinia, S., Li, L., Peng, M.-W., & Hanahan, D. (2016) · Cell Reports

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 221