The DOI matches its Crossref record; 141 of the 143 references it cites were found in a registry or an index.
Idiopathic pulmonary fibrosis
Abstract
Idiopathic pulmonary fibrosis is a prototype of chronic, progressive, and fibrotic lung disease. Healthy tissue is replaced by altered extracellular matrix and alveolar architecture is destroyed, which leads to decreased lung compliance, disrupted gas exchange, and ultimately respiratory failure and death. In less than a decade, understanding of the pathogenesis and management of this disease has been transformed, and two disease-modifying therapies have been approved, worldwide. In this Seminar, we summarise the presentation, pathophysiology, diagnosis, and treatment options available for patients with idiopathic pulmonary fibrosis. This disease has improved understanding of the mechanisms of lung fibrosis, and offers hope that similar approaches will transform the management of patients with other progressive fibrotic lung diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“marked by interstitial pneumonia, dyspnea and cough25, histologically characterized by fibroblast proliferation and extracellular matrix remodeling26–29.”
From A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial (2025) · cites this paper as [26]
In the citing paper
“The median survival time after diagnosis is 2–4 years despite widespread availability of targeted antifibrotic therapies26,30, highlighting the ongoing need for novel, effective therapies to treat IPF.”
From A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial (2025) · cites this paper as [26]
In the citing paper
“Clinical trials investigating these two drugs in patients with IPF have demonstrated only a slowing of disease progression33,34, as measured by forced vital capacity (FVC) and self-reported quality of life (QOL) metrics, and unclear benefit to survival26, making the development of therapies that can restore lung function and reverse the course of disease a priority.”
From A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial (2025) · cites this paper as [26]
In the citing paper
“IPF is an age-related, progressive lung disease diagnosed by excluding other potential causes of interstitial lung disease (for example, environmental exposures, connective tissue disease, hypersensitivity pneumonitis or drug toxicities)24 and marked by interstitial pneumonia, dyspnea and cough25, histologically characterized by fibroblast proliferation and extracellular matrix remodeling26–29.”
From A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial (2025) · cites this paper as [26]
In the citing paper
“These observations indicate that the Pdgf pathway is crucial to disease pathogenesis.”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [39]
Citations
Cites
Cancer Incidence in Five Continents
Doll, R., Muir, C. S., & Waterhouse, J. A. H. (1970) · Springer eBooks · doi:10.1007/978-3-642-85851-2 · Cited by 8,485
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186
Self-citationEfficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis
Richeldi, L., du Bois, R. M., Raghu, G., Azuma, A., Brown, K. K., Costabel, U., Cottin, V., Flaherty, K. R., Hansell, D. M., Inoue, Y., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402584 · Cited by 4,654
Self-citationTravis, W. D., Costabel, U., Hansell, D. M., King, T. E., Lynch, D. A., Nicholson, A. G., Ryerson, C. J., Ryu, J. H., Selman, M., Wells, A. U., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201308-1483st · Cited by 4,378
Self-citation(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196
Fleischner Society: Glossary of Terms for Thoracic Imaging
Hansell, D. M., Bankier, A. A., MacMahon, H., McLoud, T. C., Müller, N. L., & Rémy, J. (2008) · Radiology · doi:10.1148/radiol.2462070712 · Cited by 4,189
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
King, T. E., Bradford, W. Z., Castro-Bernardini, S., Fagan, E. A., Glaspole, I., Glassberg, M. K., Gorina, E., Hopkins, P. M., Kardatzke, D., Lancaster, L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402582 · Cited by 3,975
Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment: International Consensus Statement
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.2.ats3-00 · Cited by 2,651
Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials
Noble, P. W., Albera, C., Bradford, W. Z., Costabel, U., Glassberg, M. K., Kardatzke, D., King, T. E., Lancaster, L., Sahn, S. A., Szwarcberg, J., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60405-4 · Cited by 2,154
Raghu, G., Rochwerg, B., Zhang, Y., Garcia, C. A. C., Azuma, A., Behr, J., Brozek, J. L., Collard, H. R., Cunningham, W., Homma, S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1063st · Cited by 1,916
Self-citation
Research works printed but not linked: 1
- 2000, Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS), Am J Respir Crit Care Med, 161, 646, 10.1164/ajrccm.161.2.ats3-00 · DOI
Cited by
Sorted by citations
Items 501–600 of 1,003
Double-edged mitophagy: balancing inflammation and resolution in lung disease
Tian, S., Zhang, Y., Liu, C. X., Zhang, H., Lu, Q., Zhao, Y., & Fan, H. (2025) · Clinical Science · doi:10.1042/cs20256705 · Cited by 29
Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping
D’Alessandro‐Gabazza, C. N., Méndez–García, C., Hataji, O., Westergaard, S., Watanabe, F., Yasuma, T., Toda, M., Fujimoto, H., Nishihama, K., Fujiwara, K., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01892 · Cited by 28
Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis
Savigny, F., Schricke, C., Lacerda‐Queiroz, N., Meda, M., Nascimento, M., Huot-Marchand, S., Monteiro, F. D. G., Ryffel, B., Gombault, A., Bert, M. L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588799 · Cited by 27
Yu, C., Bao, H., Chen, Z., Li, X., Liu, X., Wang, W., Huang, J., & Zhang, Z. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02997a · Cited by 27
Chen, L., Yang, Y., Yan, H., Peng, X., & Zou, J. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57247 · Cited by 27
Chang, K., Zhang, X., Lin, S., Lin, S., Lin, Y., Akhrymuk, I. V., Lin, S., & Lin, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011152 · Cited by 27
Hao, X., Hao, J., Chen, C., Peng, H., Zhang, J., Cao, Q., & Liu, L. (2021) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivab350 · Cited by 30
Yin, J., Wang, J., Zhang, X., Liao, Y., Luo, W. F., Wang, S., Ding, J., Huang, J., Chen, M., Wang, W., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00761-2 · Cited by 26
Wang, Z., Wang, W., Xiang, T., Gong, B., & Xie, J. (2022) · Inflammation · doi:10.1007/s10753-022-01661-w · Cited by 31
Evangelista-Leite, D., Carreira, A. C. O., Nishiyama, M. Y., Gilpin, S. E., & Miglino, M. A. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122338 · Cited by 27
An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis
Aryal, S., & Nathan, S. D. (2018) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2018.1471465 · Cited by 26
Lin, Y., Shi, Y., Su, X., Ouyang, L., Wang, G., & Ye, T. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113714 · Cited by 26
Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis
Zheng, P., Sun, S., Wang, J., Cheng, Z. J., Lei, K. C., Xue, M., Zhang, T., Huang, H., Zhang, X. D., & Sun, B. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04094-0 · Cited by 27
MicroRNA-34a: A Novel Therapeutic Target in Fibrosis
Zhao, M., Qi, Q., Liu, S., Huang, R. S., Shen, J., Zhu, Y., Chai, J., Zheng, H., Wu, H., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.895242 · Cited by 27
Lifestyle, Genetic Susceptibility, and the Risk of Idiopathic Pulmonary Fibrosis
Ma, Y., Cui, F., Li, D., Wang, J., Tang, L., Xie, J., Hu, Y., & Tian, Y. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.04.008 · Cited by 26
Alaaeldin, R., Mohyeldin, R. H., Bekhit, A. A., Gomaa, W. M., Zhao, Q., & Fathy, M. (2023) · Molecules · doi:10.3390/molecules28124665 · Cited by 26
Liu, Y., Tang, A., Liu, M., Xu, C., Cao, F., & Yang, C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116983 · Cited by 25
Adipokine expression in systemic sclerosis lung and gastrointestinal organ involvement
Neumann, E., Lepper, N., Vasile, M., Riccieri, V., Peters, M. A., Meier, F. M. P., Hülser, M.-L., Distler, O., Gay, S., Mahavadi, P., et al. (2019) · Cytokine · doi:10.1016/j.cyto.2018.11.013 · Cited by 26
Shao, R., Wang, F., Lyu, M., Yang, J., Zhang, P., & Zhu, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00412 · Cited by 27
Fibrosis in tissue engineering and regenerative medicine: treat or trigger?
Fernández‐Colino, A., Iop, L., Ferreira, M. S. V., & Mela, P. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.07.007 · Cited by 28
Du, M., Duan, J., Zhang, C., Yang, H., Guan, X., Zhong, W., Liu, Y., Li, Z., Cheng, Y., Zhou, Y., et al. (2019) · Cell Biology International · doi:10.1002/cbin.11205 · Cited by 27
Therapeutic Targeting of IL-11 for Chronic Lung Disease
Kortekaas, R. K., Burgess, J. K., van Orsoy, R., Lamb, D. J., Webster, M. J., & Gosens, R. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.01.007 · Cited by 26
Relationship between asporin and extracellular matrix behavior: A literature review
Fan, R., Yan, X., & Zhang, W. (2022) · Medicine · doi:10.1097/md.0000000000032490 · Cited by 25
Thalidomide interaction with inflammation in idiopathic pulmonary fibrosis
Dsouza, N. N., Alampady, V., Baby, K., Maity, S., Byregowda, B. H., & Nayak, Y. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01193-1 · Cited by 25
TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation
Wu, M., Wang, Z., Shi, X., Zan, D., Chen, H., Yang, S., Ding, F., Liu, Y., Tan, P., Ma, R. Z., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02533-z · Cited by 25
Wu, Z., Shi, R., Yan, S., Zhang, S., Lü, B., Huang, Z., & Ji, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155368 · Cited by 25
Wang, S. F., Li, J., Wu, C., Lei, Z., Wang, T., Huang, X., Zhang, S., Liu, Y., Bi, X., Zheng, F., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111669 · Cited by 25
Zou, M., Zhang, G., Zou, J., Liu, Y., Liu, B., Hu, X., & Cheng, Z. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111886 · Cited by 26
Zhang, R., Xu, L., An, X., Sui, X., & Lin, S. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4574 · Cited by 27
Antoniou, K. M., Kamekis, A., Symvoulakis, E. K., Kokosi, M. A., & Swigris, J. J. (2020) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000703 · Cited by 26
Liu, Y., & Qi, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106774 · Cited by 25
Wang, S., Li, J., He, Y., Ran, Y., Lu, B., Gao, J., Shu, C., Li, J., Zhao, Y., Zhang, X., et al. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120584 · Cited by 25
Faheem, N. M., Askary, A. E., & Gharib, A. F. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14140-w · Cited by 25
Shao, S., Qu, Z., Liang, Y., Xu, Y., Zhou, D., Li, D., Zhang, Y., & Yin, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107936 · Cited by 25
Barochia, A. V., Kaler, M. M., Weir, N. A., Gordon, E. M., Figueroa, D. M., Yao, X., Woldehanna, M. L., Sampson, M. L., Remaley, A. T., Grant, G. M., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.04053-2020 · Cited by 25
A Senescence Bystander Effect in Human Lung Fibroblasts
Waters, D. W., Schuliga, M. J., Pathinayake, P. S., Wei, L., Tan, H.-Y., Blokland, K. E. C., Jaffar, J., Westall, G. P., Burgess, J. K., Prêle, C. M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9091162 · Cited by 25
Achaiah, A., Rathnapala, A., Pereira, A. Z., Bothwell, H., Dwivedi, K., Barker, R., Benamore, R. E., Hoyles, R. K., Iotchkova, V., & Ho, L. (2021) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2021-000899 · Cited by 25
Qin, X., Jia, C., Liang, J., Chen, J., Liu, X., Chao, Z., Qin, H., Yuan, Y., Liu, Z., Zhang, Z., et al. (2022) · Respiratory Research · doi:10.1186/s12931-022-02027-4 · Cited by 25
Jeon, H., Lee, A.-J., & Ha, K. (2022) · BioChip Journal · doi:10.1007/s13206-022-00057-0 · Cited by 26
Takeuchi, T., Hayashi, M., Tamita, T., Nomura, Y., Kojima, N., Mitani, A., Takeda, T., Hitaka, K., Kato, Y., Kamitani, M., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00613 · Cited by 26
Exosomes in pathogenesis, diagnosis, and treatment of pulmonary fibrosis
Yang, Y., Liu, Y., Chai, Y., Liu, K., Hu, W., Zhao, K., Zhu, Y., Gao, P., Huang, Q., & Zhang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927653 · Cited by 25
Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk
Mohammadi‐Nejad, A., Allen, R. J., Kraven, L. M., Leavy, O. C., Jenkins, G. R., Wain, L. V., Auer, D. P., & Sotiropoulos, S. N. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104356 · Cited by 26
A comprehensive review of emodin in fibrosis treatment
HaoShang, Jia, X., Liu, H., Zhang, X., & Shao, Y. (2022) · Fitoterapia · doi:10.1016/j.fitote.2022.105358 · Cited by 25
Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo
Elliot, S. J., Catanuto, P., Pereira‐Simon, S., Xia, X., Shahzeidi, S., Roberts, E. R., Ludlow, J. W., Hamdan, S., Daunert, S., Parra, J., et al. (2022) · eLife · doi:10.7554/elife.79543 · Cited by 26
Ding, L., Qi, H., Wang, Y., Zhang, Z., Liu, Q., Guo, C., Liu, J., Chen, Z., Li, J., Chen, J., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114096 · Cited by 25
Yan, L., Hou, C., Liu, J., Wang, Y., Zeng, C., Yu, J., Zhou, T., Zhou, Q., Duan, S., & Xiong, W. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2314-8 · Cited by 26
Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition
Pi, P., Zeng, Z., Zeng, L., Han, B., Bai, X., & Xu, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1218059 · Cited by 29
Kawamura, K., Ichikado, K., Ichiyasu, H., Anan, K., Yasuda, Y. U., Suga, M., & Sakagami, T. (2019) · BMC Pulmonary Medicine · doi:10.1186/s12890-019-0880-0 · Cited by 24
Zhang, L., Cheng, S., Jiang, X., Zhang, J., Meng, P., Tang, Q., Qin, X., Wang, B., Chen, C., & Zou, Z. (2019) · Toxicology · doi:10.1016/j.tox.2019.152244 · Cited by 25
Pharmacological management of Idiopathic Pulmonary Fibrosis: current and emerging options
Trachalaki, A., Irfan, M., & Wells, A. U. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1822326 · Cited by 25
Wang, S., Yu, J., Liu, Y., Yu, J., Ma, Y., Zhou, L., Liu, X., Liu, L., Li, W., & Niu, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117680 · Cited by 24
Ji, H., Song, X., Lv, X., Shao, F., Yu, L., Song, Y., Song, W., Qiao, P., Gai, Y., Jiang, D., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17060726 · Cited by 24
Li, Y., Yin, H., Yuan, H., Wang, E., Wang, C., Li, H., Geng, X., Zhang, Y., & Bai, J. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-03260-x · Cited by 23
Zheng, H., Yu, J., Gao, L., Wang, K., Xu, Z., Zeng, Z., Zheng, K., Tang, X., Tian, X., Zhao, Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57124-x · Cited by 26
Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis
Zhou, Y., Zhang, B., Li, C., Huang, X., Cheng, H., Bao, X., Zhao, F., Cheng, Q., Yue, S., Han, J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1903-8 · Cited by 24
Khedoe, P. P. S. J., Marges, E. R., Hiemstra, P. S., Ninaber, M. K., & Geelhoed, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01990 · Cited by 24
Emerging physiological and pathological roles of MeCP2 in non-neurological systems
Wang, J., Xiao, Y., Liu, C., Huang, Y., Petersen, R. B., Zheng, L., & Huang, K. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108768 · Cited by 23
Automated Digital Quantification of Pulmonary Fibrosis in Human Histopathology Specimens
Testa, L. C., Julé, Y., Lundh, L., Bertotti, K., Merideth, M. A., O’Brien, K., Nathan, S. D., Venuto, D. C., El‐Chemaly, S., Malicdan, M. C. V., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.607720 · Cited by 24
Chen, H., He, A., Li, H., Chen, H., Xie, H., Luo, L., Huang, Y., Chen, J., Guan, J., He, Q., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04232-3 · Cited by 25
Lü, Y., Zhang, Y., Pan, Z., Yang, C., Chen, L., Wang, Y., Xu, D., Xia, H., Wang, S., Chen, S., et al. (2022) · Nutrients · doi:10.3390/nu14051094 · Cited by 27
Extracellular vesicles in respiratory disease
Carnino, J. M., & Lee, H. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2021.07.008 · Cited by 26
Hussein, R. M., Arafa, E. A., Raheem, S. A., & Mohamed, W. R. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121256 · Cited by 24
Smoking-related interstitial lung disease
Gotarredona, M. P. S., Herrero, S. N., Izquierdo, L. G., & Portal, J. A. R. (2022) · Radiología (English Edition) · doi:10.1016/j.rxeng.2022.10.008 · Cited by 24
Ji, H.-M., Dong, H., Lan, Y., Bi, Y., Gu, X., Han, Y., Yang, C., Cheng, M.-H., & Gao, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1089812 · Cited by 24
Ding, D.-L., Shen, X., Yu, L., Zheng, Y., Liu, Y., Wang, W., Liu, L., Zhao, Z., Nian, S., & Liu, L. (2023) · Phytotherapy Research · doi:10.1002/ptr.7774 · Cited by 24
Protective Effect of Tunisian Flaxseed Oil against Bleomycin-Induced Pulmonary Fibrosis in Rats
Abidi, A., Kourda, N., Feki, M., & Khamsa, S. B. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1622741 · Cited by 24
Treatment of idiopathic pulmonary fibrosis with Nintedanib: an update
Wongkarnjana, A., Yanagihara, T., & Kolb, M. R. J. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1673733 · Cited by 23
Wong, A. H., & Tran, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00064 · Cited by 24
Liu, M., Zhang, T., Zang, C., Cui, X.-L., Li, J., & Wang, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1856222 · Cited by 24
Zhang, G., Shi, L., Li, J., Wang, S., Ren, J., Wang, D., Hu, P., Wang, Y., & Li, C. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01659-9 · Cited by 24
Macisaac, S., Somboonviboon, D., Scallan, C. J., & Kolb, M. R. J. (2024) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2024.2340723 · Cited by 25
Peng, J., Wang, Q., Sun, R., Zhang, K., Chen, Y. C., & Gong, Z. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.026 · Cited by 23
Polymeric Micelles for Pulmonary Drug Delivery: A Comprehensive Review
Teama, M. T., Abdelmalak, N. S., Naguib, M. J., & Ahmed, S. (2025) · BioNanoScience · doi:10.1007/s12668-025-02105-z · Cited by 23
New trajectories in the treatment of interstitial lung disease
Morisset, J., & Lee, J. S. (2019) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000600 · Cited by 23
Wang, B., Bai, W., Ma, H., & Li, F. (2020) · Medical Science Monitor · doi:10.12659/msm.927577 · Cited by 23
Arginine is a key player in fibroblasts during the course of IPF development
Wang, Y., Zhao, J., Zhang, H., & Wang, C. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.02.023 · Cited by 23
Wang, P., Leung, J., Lam, A., Lee, S., Calabrese, D. R., Hays, S. R., Golden, J. A., Kukreja, J., Singer, J. P., Wolters, P. J., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.11.012 · Cited by 24
FGF19 is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits Lung Fibrosis in Mice
Justet, A., Ghanem, M., Boghanim, T., Hachem, M., Vasarmidi, E., Jaillet, M., Vadel, A., Joannes, A., Mordant, P., Bonniaud, P., et al. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0246oc · Cited by 26
Sehgal, M., Jakhete, S. M., Manekar, A. G., & Sasikumar, S. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09773 · Cited by 23
Cai, Z., Tian, Y., Li, J.-Z., Zhao, P., Li, J., Mei, X., & Bai, Y. (2022) · Bioscience Reports · doi:10.1042/bsr20220986 · Cited by 23
Lv, K., Wang, Y., Lou, P., Liu, S., Zhou, P., Yang, L., Lu, Y., Cheng, J., & Liu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1042983 · Cited by 24
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF
Wang, L., Zhao, W., Xia, C., Li, Z., Zhao, W., Xu, K., Wang, N., Lian, H., Rosas, I. O., & Yu, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415705 · Cited by 24
Cuproptosis-related gene CDKN2A as a molecular target for IPF diagnosis and therapeutics
Xu, B., Yang, K., Han, X., & Hou, J. (2023) · Inflammation Research · doi:10.1007/s00011-023-01739-7 · Cited by 24
Yang, J., Shi, X., Gao, R., Fan, L., Chen, R., Cao, Y., Xu, T., & Yang, J. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17937 · Cited by 24
Huh, J.-Y., Lee, J. H., & Song, J. W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1301923 · Cited by 25
Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives
Wang, W., Zhong, Z., Huang, Z., Hiew, T. N., Huang, Y., Wu, C., & Pan, X. (2024) · Nanoscale · doi:10.1039/d3nr05487j · Cited by 26
Bonadio, J. D., Bashiri, G., Halligan, P., Kegel, M., Ahmed, F., & Wang, K. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115303 · Cited by 24
Sakayori, M., Terada, J., Abe, M., Hirasawa, Y., Suzuki, K., Yoshioka, K., Tsushima, K., & Tatsumi, K. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s208733 · Cited by 23
Ma, W., Huang, Q., Xiong, G., Deng, L., & He, Y. (2020) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2020.1721263 · Cited by 23
Pulmonary rehabilitation in patients with interstitial lung diseases: Correlates of success
Brunetti, G., Malovini, A. L., Maniscalco, M., Balestrino, A., Carone, M., Visca, D., Capelli, A., Vitacca, M., Bellazzi, R., Piaggi, G., et al. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2021.106473 · Cited by 23
Zhuo, J., Liu, D., Yu, Q., Hu, M., Huang, H., Chen, Y., Li, Y., Gao, Y., Chen, W., Meng, X., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123191 · Cited by 23
Aging Lung: Molecular Drivers and Impact on Respiratory Diseases—A Narrative Clinical Review
Górski, P., Białas, A. J., & Piotrowski, W. J. (2024) · Antioxidants · doi:10.3390/antiox13121480 · Cited by 25
Espinosa, A. M. D., Link, P. A., Sicard, D., Jorba, I., Tschumperlin, D. J., & Haak, A. J. (2020) · Journal of Cell Science · doi:10.1242/jcs.248278 · Cited by 25
Chelerythrine Ameliorates Pulmonary Fibrosis via Activating the Nrf2/ARE Signaling Pathway
Peng, L., Li, W., Shi, Q., Gao, F., Huang, B., & Wang, C. (2021) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-021-00967-0 · Cited by 22
Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases
Sala, V., Sala, A. D., Ghigo, A., & Hirsch, E. (2021) · Cell Stress · doi:10.15698/cst2021.04.246 · Cited by 23
Liu, J., Peng, D.-Y., You, J., Ou, Z., Qiu, H., Hao, C., Chen, H., Fu, Z., & Zou, L. (2021) · Stem Cells and Development · doi:10.1089/scd.2020.0208 · Cited by 23
Chen, Q., Xia, S., Sui, H. X., Shi, X., Huang, B., & Wang, T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262737 · Cited by 22
Han, M., Song, Y., Liu, S., Lu, X., Su, L., Liu, M., Zhu, X., Sun, K., Lu, Y., & Wang, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.882678 · Cited by 22
Mohamed, M. Z., Baky, M. F. A. E., Ali, M. E., & Hafez, H. M. (2022) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2022.103940 · Cited by 22
DDR1 activation in macrophage promotes IPF by regulating NLRP3 inflammasome and macrophage reaction
Wang, H., Wen, Y., Wang, L., Wang, J., Chen, H., Chen, J., Guan, J., Xie, S., Chen, Q. P., Wang, Y., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109294 · Cited by 23
Metadata
- Authors
- Richeldi, L., Collard, H. R., & Jones, M. G.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- University of California, San Francisco (US)
- National Institute for Health and Care Research (GB)
- Corresponding author
- Richeldi, Luca
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 389
- Issue
- 10082
- Pages
- 1941-1952
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2599075603
- Cited by
- 2,020
- References
- 143
- Citations by year
- 2026: 202 · 2025: 317 · 2024: 338 · 2023: 293 · 2022: 273 · 2021: 233 · 2020: 167 · 2019: 94 · 2018: 76 · 2017: 22
- FWCI
- 17.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- National Institute for Health and Care Research (CL-2016-26-004)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- idiopathic pulmonary fibrosis, pulmonary fibrosis, pathophysiology, extracellular matrix, alveolar architecture, disease-modifying therapy, diagnosis, treatment options, respiratory failure
- MeSH terms
- Humans, Idiopathic Pulmonary Fibrosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review