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Cited by 586

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Idiopathic nephrotic syndrome in children

Noone, Damien G, Iijima, Kazumoto, Parekh, Rulan·2018·The Lancet

Abstract

The incidence of idiopathic nephrotic syndrome (NS) is 1·15-16·9 per 100 000 children, varying by ethnicity and region. The cause remains unknown but the pathogenesis of idiopathic NS is thought to involve immune dysregulation, systemic circulating factors, or inherited structural abnormalities of the podocyte. Genetic risk is more commonly described among children with steroid-resistant disease. The mainstay of therapy is prednisone for the vast majority of patients who are steroid responsive; however, the disease can run a frequently relapsing course, necessitating the need for alternative immunosuppressive agents. Infection and venous thromboembolism are the main complications of NS with also increased risk of acute kidney injury. Prognosis in terms of long-term kidney outcome overall is excellent for steroid-responsive disease, and steroid resistance is an important determinant of future risk of chronic or end-stage kidney disease.

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Metadata

Authors
Noone, D. G., Iijima, K., & Parekh, R.
Venue
The Lancet
Publisher
Elsevier BV
Published
2018-07
Volume
392
Issue
10141
Pages
61-74
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2808503484
Cited by
586
References
56
FWCI
34.19
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Idiopathic nephrotic syndrome in children. https://app.cochat.ai/papers/10.1016/s0140-6736(18)30536-1
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Noone, D. G., Iijima, K., & Parekh, R. (2018). Idiopathic nephrotic syndrome in children. The Lancet. https://doi.org/10.1016/s0140-6736(18)30536-1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.