The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Chronic hepatitis B virus infection
Abstract
Chronic hepatitis B virus infection is a global public health threat that causes considerable liver-related morbidity and mortality. It is acquired at birth or later via person-to-person transmission. Vaccination effectively prevents infection and chronic hepatitis B virus carriage. In chronically infected patients, an elevated serum hepatitis B virus DNA concentration is the main risk factor for disease progression, although there are other clinical and viral parameters that influence disease outcomes. In addition to liver biochemistry, virological markers, and abdominal ultrasonography, non-invasive assessment of liver fibrosis is emerging as an important assessment modality. Long-term nucleos(t)ide-analogue therapy is safe and well tolerated, achieves potent viral suppression, and reduces the incidence of liver-related complications. However, a need to optimise management remains. Promising novel therapies are at the developmental stage. With current vaccines, therapies, and an emphasis on improving linkage to care, WHO's goal of eliminating hepatitis B virus as a global health threat by 2030 is achievable.
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Cites
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection
Lampertico, P., Agarwal, K., Berg, T., Buti, M., Janssen, H. L. A., Papatheodoridis, G., Zoulim, F., & Tacke, F. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.03.021 · Cited by 5,391
Terrault, N. A., Lok, A. S. F., McMahon, B. J., Chang, K., Hwang, J. P., Jonas, M. M., Brown, R. S., Bzowej, N. H., & Wong, J. B. (2018) · Hepatology · doi:10.1002/hep.29800 · Cited by 4,306
Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level
Chen, C.-J. (2006) · JAMA · doi:10.1001/jama.295.1.65 · Cited by 3,140
(2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.006 · Cited by 1,875
Marcellin, P., Gane, E., Buti, M., Afdhal, N., Sievert, W., Jacobson, I. M., Washington, M. K., Germanidis, G., Flaherty, J. F., Schall, R. A., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61425-1 · Cited by 1,788
Lai, C. L., Ratziu, V., Yuen, M.-F., & Poynard, T. (2003) · The Lancet · doi:10.1016/s0140-6736(03)15108-2 · Cited by 1,727
Self-citationPredicting Cirrhosis Risk Based on the Level of Circulating Hepatitis B Viral Load
Iloeje, U. H., Yang, H., Su, J., Jen, C., You, S., & Chen, C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.016 · Cited by 1,528
Randomized controlled trial of screening for hepatocellular carcinoma
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Fattovich, G., Bortolotti, F., & Donato, F. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2007.11.011 · Cited by 1,348
HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)
Thio, C. L., Seaberg, E. C., Skolasky, R., Phair, J., Visscher, B., Muñoz, A., & Thomas, D. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11913-1 · Cited by 1,099
Cited by
Ginès, P., Krag, A., Abraldes, J. G., Solà, E., Fabrellas, N., & Kamath, P. S. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01374-x · Cited by 1,663
Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases
Zeng, X., Yuan, X., Cai, Q., Tang, C., & Gao, J. (2021) · Cells · doi:10.3390/cells10081945 · Cited by 55
Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis
Su, D.-N., Wu, S.-P., & Xu, S.-Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01911-4 · Cited by 33
GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases
Qin, Z.-X., Zuo, L., Zeng, Z., Ma, R., Xie, W., Zhu, X., & Zhou, X. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2466767 · Cited by 32
Du, Y., Yan, H., Zou, S., Khera, T., Li, J., Han, M., Yang, X., Wang, B., Liu, J., Sun, S., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1676 · Cited by 9
Metadata
- Authors
- Seto, W.-K., Lo, Y.-R., Pawlotsky, J.-M., & Yuen, M.-F.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 392
- Issue
- 10161
- Pages
- 2313-2324
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2900781853
- Cited by
- 555
- References
- 109
- FWCI
- 35.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seto, W.-K., Lo, Y.-R., Pawlotsky, J.-M., & Yuen, M.-F. (2018). Chronic hepatitis B virus infection. The Lancet. https://doi.org/10.1016/s0140-6736(18)31865-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
