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Cited by 55Circular RNAs in diseasesCancer-related molecular mechanisms researchRNA Research and Splicing

Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases

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Zeng, Xianhui, Yuan, Xianglei, Cai, Qiuyu, Tang, Chengwei, Gao, Jinhang·2021·Cells
DOI 10.3390/cells10081945PMC PMC8392363
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Abstract

Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably cleared up by extracellular vesicles. CircRNAs play a pivotal role in the epigenetic regulation of gene expression at transcriptional and post-transcriptional levels. Recently, circRNAs have been demonstrated to be involved in the regulation of liver homeostasis and diseases. However, the epigenetic role and underlying mechanisms of circRNAs in chronic liver diseases remain unclear. This review discussed the role of circRNAs in non-neoplastic chronic liver diseases, including alcoholic liver disease (ALD), metabolic-associated fatty liver disease (MAFLD), viral hepatitis, liver injury and regeneration, liver cirrhosis, and autoimmune liver disease. The review also highlighted that further efforts are urgently needed to develop circRNAs as novel diagnostics and therapeutics for chronic liver diseases.

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  • circRNAs have a key role in the epigenetic mediation of gene expression at both transcriptional and post-transcriptional levels, with a demonstrated function in liver diseases and homeostasis.

    “circRNAs have a key role in the epigenetic mediation of gene expression at both transcriptional and post-transcriptional levels with a demonstrated function in liver diseases and homeostasis [73].”

    From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [73]

    The Introduction describes circRNAs regulating target-gene expression through miRNA sponging, and the Introduction and Conclusions describe their roles in liver homeostasis and chronic liver diseases. However, the passage explicitly attributing regulation at both transcriptional and post-transcriptional levels concerns lncRNAs, not circRNAs; our copy does not establish both levels for circRNAs. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • circRNAs are a recently described, not fully characterized type of exonic ncRNAs covalently bonded from 5′ to 3′ sticky ends in a circle and commonly found in mammals.

    “A recently described and not fully characterized type of exonic ncRNAs are covalently bonded from the 5′ to 3′ sticky ends in the shape of a circle, which is why they have been named circular RNAs (circRNAs) and are very commonly found in mammals.”

    From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [73]

    The Introduction (page not provided) identifies circRNAs as non-coding RNAs with a covalently closed loop, generated from pre-mRNA by back-splicing. It does not describe them as specifically exonic, say that 5′ and 3′ sticky ends bond together, or establish that they are very common in mammals. Its discussion of unclear mechanisms concerns circRNAs in chronic liver diseases, not the characterization of circRNAs generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Authors
Zeng, X., Yuan, X., Cai, Q., Tang, C., & Gao, J.
Affiliations
Sichuan University (CN)
Corresponding author
Gao, Jinhang
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2021-07-30
Volume
10
Issue
8
Pages
1945
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells10081945
PMC
PMC8392363
OpenAlex
W3187563869
Cited by
55
References
131
Citations by year
2026: 2 · 2025: 8 · 2024: 8 · 2023: 18 · 2022: 16 · 2021: 3
FWCI
1.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Natural Science Fund of China (81670551, U1702281, 81873584, 82000613 and 82000574)
  • Sichuan Science and Technology Program (2020YJ0083 and 21ZDYF1667)
  • National Key R&D Program of China (2017YFA0205404)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
circular RNA, epigenetic regulation, chronic liver disease, back-splicing, extracellular vesicles, liver homeostasis, alcoholic liver disease, metabolic-associated fatty liver disease, viral hepatitis, liver cirrhosis, autoimmune liver disease
MeSH terms
RNA, Circular, Animals, Chronic Disease, Humans, Liver, Liver Diseases, Liver Regeneration, Signal Transduction, Autoimmunity, Epigenesis, Genetic

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