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Cited by 697

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Guillain-Barré syndrome

Shahrizaila, Nortina, Lehmann, Helmar C, Kuwabara, Satoshi·2021·The Lancet

Abstract

Guillain-Barré syndrome is the most common cause of acute flaccid paralysis worldwide. Most patients present with an antecedent illness, most commonly upper respiratory tract infection, before the onset of progressive motor weakness. Several microorganisms have been associated with Guillain-Barré syndrome, most notably Campylobacter jejuni, Zika virus, and in 2020, the severe acute respiratory syndrome coronavirus 2. In C jejuni-related Guillain-Barré syndrome, there is good evidence to support an autoantibody-mediated immune process that is triggered by molecular mimicry between structural components of peripheral nerves and the microorganism. Making a diagnosis of so-called classical Guillain-Barré syndrome is straightforward; however, the existing diagnostic criteria have limitations and can result in some variants of the syndrome being missed. Most patients with Guillain-Barré syndrome do well with immunotherapy, but a substantial proportion are left with disability, and death can occur. Results from the International Guillain-Barré Syndrome Outcome Study suggest that geographical variations exist in Guillain-Barré syndrome, including insufficient access to immunotherapy in low-income countries. There is a need to provide improved access to treatment for all patients with Guillain-Barré syndrome, and to develop effective disease-modifying therapies that can limit the extent of nerve injury. Clinical trials are currently underway to investigate some of the potential therapeutic candidates, including complement inhibitors, which, together with emerging data from large international collaborative studies on the syndrome, will contribute substantially to understanding the many facets of this disease.

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Metadata

Authors
Shahrizaila, N., Lehmann, H. C., & Kuwabara, S.
Venue
The Lancet
Publisher
Elsevier BV
Published
2021-03
Volume
397
Issue
10280
Pages
1214-1228
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W4211083796
Cited by
697
References
101
FWCI
42.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Guillain-Barré syndrome. https://app.cochat.ai/papers/10.1016/s0140-6736(21)00517-1
The paper
Shahrizaila, N., Lehmann, H. C., & Kuwabara, S. (2021). Guillain-Barré syndrome. The Lancet. https://doi.org/10.1016/s0140-6736(21)00517-1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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