The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Drug therapy for osteoporosis in older adults
Abstract
The goal of osteoporosis management is to prevent fractures. Several pharmacological agents are available to lower fracture risk, either by reducing bone resorption or by stimulating bone formation. Bisphosphonates are the most widely used anti-resorptives, reducing bone turnover markers to low premenopausal concentrations and reducing fracture rates (vertebral by 50-70%, non-vertebral by 20-30%, and hip by ~40%). Bisphosphonates bind avidly to bone mineral and have an offset of effect measured in months to years. Long term, continuous use of oral bisphosphonates is usually interspersed with drug holidays of 1-2 years, to minimise the risk of atypical femoral fractures. Denosumab is a monoclonal antibody against RANKL that potently inhibits osteoclast development and activity. Denosumab is administered by subcutaneous injection every 6 months. Anti-fracture effects of denosumab are similar to those of the bisphosphonates, but there is a pronounced loss of anti-resorptive effect from 7 months after the last injection, which can result in clusters of rebound vertebral fractures. Two classes of anabolic drugs are now available to stimulate bone formation. Teriparatide and abaloparatide both target the parathyroid hormone-1 receptor, and are given by daily subcutaneous injection for up to 2 years. Romosozumab is an anti-sclerostin monoclonal antibody that stimulates bone formation and inhibits resorption. Romosozumab is given as monthly subcutaneous injections for 1 year. Head-to-head studies suggest that anabolic agents have greater anti-fracture efficacy and produce larger increases in bone density than anti-resorptive drugs. The effects of anabolic agents are transient, so transition to anti-resorptive drugs is required. The optimal strategy for cycling anabolics, anti-resorptives, and off-treatment periods remains to be determined.
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Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
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Romosozumab Treatment in Postmenopausal Women with Osteoporosis
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Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
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Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
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Role and Regulation of Transcription Factors in Osteoclastogenesis
Jiang, T., Xia, T., Qiao, F., Wang, N., Jiang, Y., & Xin, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216175 · Cited by 60
Osteosarcopenia in NAFLD/MAFLD: an underappreciated clinical problem in chronic liver disease
Musio, A., Perazza, F., Leoni, L., Stefanini, B., Dajti, E., Menozzi, R., Petroni, M. L., Colecchia, A., & Ravaioli, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087517 · Cited by 26
Metadata
- Authors
- Reid, I. R., & Billington, E. O.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 399
- Issue
- 10329
- Pages
- 1080-1092
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W4220705422
- Cited by
- 698
- References
- 96
- FWCI
- 122.80
- Type
- journal article
- Language
- en
- Open access
- closed
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