Cited by 87Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisHIV, TB, and STIs Epidemiology

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Scientific advances and the end of tuberculosis: a report from the Lancet Commission on Tuberculosis

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  • A new set of tuberculosis control technologies provides grounds for optimism in reaching a tuberculosis-free world within a generation.

    “Last year, the Lancet Commission on Tuberculosis published its report “Scientific advances and the end of tuberculosis,” which argued that a new set of tuberculosis control technologies provided grounds for optimism in reaching a tuberculosis-free world within a generation.52”
  • Using new diagnostics along the case finding cascade could reap large benefits.

    “Using new diagnostics along the case finding “cascade”—for those with subclinical tuberculosis, those with symptoms who have not sought care, and those who have sought care but are undiagnosed—could reap large benefits.52”
  • The WHO and the US Centers for Disease Control and Prevention recently approved the 4-month isoniazid-rifapentine-moxifloxacin-pyrazinamide (4HPMZ) regimen for eligible people with drug-susceptible tuberculosis.

    “The WHO and the US Centers for Disease Control and Prevention recently approved the 4-month isoniazid–rifapentine–moxifloxacin–pyrazinamide (4HPMZ) regimen for eligible people with drug-susceptible tuberculosis, which “speaks to the momentum of the development of new treatments for drug-susceptible tuberculosis.”52”
  • For a tuberculosis-free world within a generation, new tuberculosis control tools would need to be adopted wholesale, implemented at scale, and accompanied by sustained investment in development of new tools and in tuberculosis programmes.

    “Such tools, it argued, would need to be adopted wholesale, implemented at scale, and accompanied by sustained investment in development of new tools and in tuberculosis programmes for this vision to be achieved.”

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Metadata

Authors
Reid, M., Agbassi, Y. J. P., Arinaminpathy, N., Bercasio, A., Bhargava, A., Bhargava, M., Bloom, A., Cattamanchi, A., Chaisson, R., Chin, D., Churchyard, G., Cox, H., Denkinger, C. M., Ditiu, L., Dowdy, D., Dybul, M., Fauci, A., Fedaku, E., Gidado, M., Harrington, M., Hauser, J., Heitkamp, P., Herbert, N., Herna Sari, A., Hopewell, P., Kendall, E., Khan, A., Kim, A., Koek, I., Kondratyuk, S., Krishnan, N., Ku, C.-C., Lessem, E., McConnell, E. V., Nahid, P., Oliver, M., Pai, M., Raviglione, M., Ryckman, T., Schäferhoff, M., Silva, S., Small, P., Stallworthy, G., Temesgen, Z., van Weezenbeek, K., Vassall, A., Velásquez, G. E., Venkatesan, N., Yamey, G., Zimmerman, A., Jamison, D., Swaminathan, S., & Goosby, E.
Affiliations
  • University of California, San Francisco (US)
  • Yenepoya University (IN)
  • Imperial College London (GB)
  • United States Agency for International Development (US)
  • University of California, Irvine (US)
  • Johns Hopkins University (US)
  • Gates Foundation (US)
  • Aurum Institute (ZA)
  • University of Cape Town (ZA)
  • University Hospital Heidelberg (DE)
  • Georgetown University (US)
  • National Institutes of Health (US)
  • KNCV TB Plus (NL)
  • Treatment Action Group (US)
  • McGill University (CA)
  • Parliament of United Kingdom (GB)
  • Interactive Research and Development (PK)
  • Save the Children (US)
  • University of Milan (IT)
  • Harvard University (US)
  • Mayo Clinic (US)
  • London School of Hygiene & Tropical Medicine (GB)
  • University of Oxford (GB)
  • Duke University (US)
  • M S Swaminathan Research Foundation (IN)
Corresponding author
Reid, Michael
Venue
The Lancet
Publisher
Elsevier BV
Published
2023-10
Volume
402
Issue
10411
Pages
1473-1498
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W4386700370
Cited by
87
References
4
Citations by year
2026: 26 · 2025: 33 · 2024: 25 · 2023: 3
FWCI
4.13
Type
journal article
Language
en
Open access
closed
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • World Health Organization
  • Medical Research Council (MR/R015600/1)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV, TB, and STIs Epidemiology
Keywords
tuberculosis, tuberculosis elimination, drug-resistant tuberculosis, tuberculosis treatment outcomes, tuberculosis mortality
MeSH terms
Humans, Tuberculosis, Global Health

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