The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
TRANSFERRIN AND TRANSFERRIN RECEPTORS IN CARCINOMA OF THE BREAST
Abstract
Breast tissues from 59 patients were immunohistologically studied for transferrin and transferrin receptors. None of the 8 normal breasts or 22 benign mastopathies, and only 1 of 7 fibroadenomas were reactive for transferrin, but 16 (72.7%) of 22 carcinomas were positive and parallel sections showed histopathologically that the rective areas were confined to tumour-cell membranes. That breast-tumour transferrin is probably receptor-bound in vivo was indicatd by its complete chemical removal in vitro and return to the same cells following reincubation with dilute solutions of transferrin. Similar bindig is found on certain normal or transformed cells and at the maternofetal interface of human placentae. It is suggested that this oncofetal receptor preferentially binds apotransferrin and may offer a novel approach to more specific therapy of certain breast cancers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Upregulation of this highly conserved iron acquisition pathway is found in a variety of cancers, including breast and colon [90,91,92,93].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [90]
Citations
Cites
Host antigens in schistosomiasis
Smithers, S. R., Terry, R. J., & HOCKLEY, D. J. (1969) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1969.0007 · Cited by 281
Glutaradehyde-activated aminohexyl-derivative of sepharose 4B as a new versatile immunoabsorbent
Cambiaso, C. L., Goffinet, A., Vaerman, J. P., & Heremans, J. F. (1975) · Immunochemistry · doi:10.1016/0019-2791(75)90175-5 · Cited by 217
Hakomori, S., Wang, S.-M., & Young, W. W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.3023 · Cited by 181
Faulk, W. P., Temple, A., Lovins, R. E., & SMITH, N. C. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.4.1947 · Cited by 178
Wada, H., Hass, P. E., & Sussman, H. H. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86360-3 · Cited by 174
Faulk, W. P., & Johnson, P. (1977) · PubMed · Cited by 134
Transferrin binding by human lymphoblastoid cell lines and other transformed cells
Galbraith, G. M. P., Galbraith, R. M., & Faulk, W. P. (1980) · Cellular Immunology · doi:10.1016/0008-8749(80)90072-6 · Cited by 100
Recent Developments in Immunofluorescence
Faulk, W. P., & Hijmans, W. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000393067 · Cited by 86
Faulk, W. P., & Galbraith, G. M. P. (1979) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1979.0014 · Cited by 81
Johnson, P., & Faulk, W. P. (1978) · PubMed · Cited by 69
Transferrin Receptor in Human Placental Brush Border Membranes
Wada, H., Hass, P. E., & Sussmang, H. H. (1979) · Cited by 67
Transferrin receptors on the human placental microvillous membrane.
Loh, T. T., Higuchi, D. A., van BOCKXMEER, F. M., Smith, C. H., & Brown, E. B. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109773 · Cited by 64
Immunological studies of transferrin and transferrin receptors of human placental trophoblast
Galbraith, G. M. P., Galbraith, R. M., & Faulk, W. P. (1980) · Placenta · doi:10.1016/s0143-4004(80)80014-2 · Cited by 58
Trophoblast modulation of maternal allogeneic recognition.
McIntyre, J. A., & Faulk, W. P. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.4029 · Cited by 53
A Method for the Use of Immunofluorescence on Paraffin-embedded Tissues
Dorsett, B. H., & Ioachim, H. L. (1978) · American Journal of Clinical Pathology · doi:10.1093/ajcp/69.1.66 · Cited by 50
Transferrin and iron uptake by human cells in culture
Hemmaplardh, D., & MORGAN, E. (1974) · Experimental Cell Research · doi:10.1016/0014-4827(74)90543-6 · Cited by 47
Recent Developments in Immunofluorescence (with colour plates I and II)
Faulk, P., & Hijmans, W. (1972) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000313167 · Cited by 34
Blood group and tissue genetic markers in familial adenocarcinoma: potential specific immunotherapy.
Levine, P. (1978) · PubMed · Cited by 21
Research works printed but not linked: 3
- Faulk, 1980, Immunological studies of human placentæ: Basic and practical implications, Rec Adv Clin Immunol, 2, 1
- Galbraith, 1979, Removal of unwanted staining in fluroescence microscopy, J Lab Clin Immunol, 1, 163
- Faulk, 1976, Non-specific factors of resittance in human plancentæ, Protides Biol Fluids, 24, 139
Cited by
Sorted by citations
Knovich, M. A., Storey, J. A., Coffman, L. G., Torti, S. V., & Torti, F. M. (2008) · Blood Reviews · doi:10.1016/j.blre.2008.08.001 · Cited by 687
Mitochondria regulation in ferroptosis
Wang, H., Liu, C., Zhao, Y., & Gao, G. (2019) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2019.151058 · Cited by 659
Daniels‐Wells, T. R., Delgado, T., Rodríguez, J. A., Helguera, G. F., & Penichet, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.06.010 · Cited by 646
Transferrin receptors in human tissues: their distribution and possible clinical relevance.
Gatter, K. C., Brown, G., Trowbridge, I. S., Woolston, R.-E., & Mason, D. Y. (1983) · Journal of Clinical Pathology · doi:10.1136/jcp.36.5.539 · Cited by 530
Laske, D. W., Youle, R. J., & Oldfield, E. H. (1997) · Nature Medicine · doi:10.1038/nm1297-1362 · Cited by 522
Metadata
- Authors
- Page Faulk, W., Hsi, B.-L., & Stevens, P. J.
- Affiliations
- Queen Victoria Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1980-08
- Volume
- 316
- Issue
- 8191
- Pages
- 390-392
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2079229575
- Cited by
- 280
- References
- 18
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 8 · 2015: 3 · 2014: 8 · 2013: 6 · 2012: 8
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- transferrin, transferrin receptor, breast cancer, apotransferrin, oncofetal protein, tumor cell membrane, fibroadenoma, benign breast disease, breast cancer treatment
- MeSH terms
- Breast, Breast Neoplasms, Cell Membrane, Female, Fetal Proteins, Fluorescent Antibody Technique, Humans, Receptors, Cell Surface, Transferrin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
