Cited by 280Iron Metabolism and DisordersBreast Cancer Treatment StudiesFerroptosis and cancer prognosis

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TRANSFERRIN AND TRANSFERRIN RECEPTORS IN CARCINOMA OF THE BREAST

Page Faulk, W., Hsi, Bae-Li, Stevens, P.J.·1980·The Lancet

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Abstract

Breast tissues from 59 patients were immunohistologically studied for transferrin and transferrin receptors. None of the 8 normal breasts or 22 benign mastopathies, and only 1 of 7 fibroadenomas were reactive for transferrin, but 16 (72.7%) of 22 carcinomas were positive and parallel sections showed histopathologically that the rective areas were confined to tumour-cell membranes. That breast-tumour transferrin is probably receptor-bound in vivo was indicatd by its complete chemical removal in vitro and return to the same cells following reincubation with dilute solutions of transferrin. Similar bindig is found on certain normal or transformed cells and at the maternofetal interface of human placentae. It is suggested that this oncofetal receptor preferentially binds apotransferrin and may offer a novel approach to more specific therapy of certain breast cancers.

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Authors: Page Faulk, W., Hsi, B.-L., & Stevens, P. J.
Affiliations: Queen Victoria Hospital (GB)
Venue: The Lancet
Publisher: Elsevier BV
Published: 1980-08
Volume: 316
Issue: 8191
Pages: 390-392
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(80)90440-7
OpenAlex: W2079229575
Cited by: 280
References: 18
Citations by year: 2026: 2 · 2025: 8 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 8 · 2015: 3 · 2014: 8 · 2013: 6 · 2012: 8
FWCI: 8.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: transferrin, transferrin receptor, breast cancer, apotransferrin, oncofetal protein, tumor cell membrane, fibroadenoma, benign breast disease, breast cancer treatment
MeSH terms: Breast, Breast Neoplasms, Cell Membrane, Female, Fetal Proteins, Fluorescent Antibody Technique, Humans, Receptors, Cell Surface, Transferrin

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TRANSFERRIN AND TRANSFERRIN RECEPTORS IN CARCINOMA OF THE BREAST

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