EXAMINATION OF A MYOPATHY BY PHOSPHORUS NUCLEAR MAGNETIC RESONANCE
Abstract
A 16-year-old boy with myopathy, ophthalmoplegia, and raised basal metabolic rate was examined by the non-invasive technique of phosphorus-31 nuclear magnetic resonance (31 P NMR). The muscles of the forearm showed an abnormal 31P NMR spectrum with a high inorganic phosphate (Pi) content in relation to phosphocreatine (PCr) (PCr/Pi = 4; control = 10). This finding was compatible with the abnormality of mitochondrial function already established by biopsy and offers in addition an explanation for the raised oxygen consumption in this patient. The method of 31P NMR is suited to rapid non-invasive diagnosis in various muscle disorders.
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Frank mitochondrial dysfunction in humans (e.g., myopathies with impaired electron transport chain activity) is accompanied by increased fuel oxidation to compensate for impaired mitochondrial ATP synthesis.
“For instance, frank mitochondrial dysfunction in humans (e.g., myopathies with impaired electron transport chain activity) is accompanied by increased fuel oxidation to compensate for the impaired mitochondrial ATP synthesis ([13](#r13)).”
From Metabolic flexibility and insulin resistance (2008) · cites this paper as [13]
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- Authors
- Gadian, D., Ross, B., Bore, P., Radda, G., Hockaday, J., Taylor, D., & Styles, P.
- Affiliations
- University of Oxford (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1981-10
- Volume
- 318
- Issue
- 8250
- Pages
- 774-775
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2064697145
- Cited by
- 86
- References
- 4
- Citations by year
- 2018: 2 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myopathy, phosphocreatine, inorganic phosphate, mitochondrial dysfunction, ophthalmoplegia, hypermetabolism, non-invasive diagnosis, muscle disorders, adolescents
- MeSH terms
- Acidosis, Adolescent, Humans, Hydrogen-Ion Concentration, Lactates, Male, Mitochondria, Muscle, Muscular Diseases, Magnetic Resonance Spectroscopy, Oxygen Consumption, Phosphates, Phosphocreatine, Phosphorus Radioisotopes
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