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IDENTIFICATION OF PLACENTAL PROTEIN 14 AS AN IMMUNOSUPPRESSIVE FACTOR IN HUMAN REPRODUCTION
Abstract
Extracts of human decidual tissue obtained in the first trimester of pregnancy showed potent suppressive activity in mixed lymphocyte cultures. These extracts contained substantial amounts of the decidual protein PP14. Purified PP14 also exhibited in vitro immunosuppressive activity, and such activity in decidual extract and purified PP14 preparations was removed by treatment with a monoclonal anti-PP14 antibody-based immunoadsorbent. PP14 was present in seminal plasma, which also exhibited immunosuppressive activity that could be reduced, but not removed, by the immunoadsorbent. PP14 may be an important immunomodulator in the human reproductive system.
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“As an example, the high glycodelin concentrations in peritoneal fluid might protect early lesions from NK cell attack (261, 262) and could thus facilitate survival.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [261]
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Jeschke, U. (2000) · Springer eBooks · doi:10.1007/978-3-642-57222-7_6 · Cited by 1
Koistinen, R. A., Julkunen, M., Riittinen, L., Suikkari, A., & Seppälä, M. T. (1991) · Springer eBooks · doi:10.1007/978-1-4471-1802-2_15 · Cited by 1
Medical Complications in Patients after Cardiac Transplantation
OʼConnell, J. B. (1991) · Springer eBooks · doi:10.1007/978-1-4612-3008-3_11 · Cited by 1
A pregnant possibility: crossing fetal tolerance with hematopoiesis.
Furmanski, P. (1994) · PubMed Central
Metadata
- Authors
- Bolton, A. E., Clough, K. J., Stoker, R. J., Pockley, A. G., Mowles, E. A., Westwood, O. M. R., & Chapman, M. G.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1987-03
- Volume
- 329
- Issue
- 8533
- Pages
- 593-595
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W1998710143
- Cited by
- 220
- References
- 30
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- placental protein 14, immunosuppression, decidua, first trimester, mixed lymphocyte reaction, seminal plasma, immunoadsorbent, immunomodulation, human reproduction
- MeSH terms
- Glycodelin, Animals, Antibodies, Monoclonal, Endometrium, Female, Glycoproteins, Humans, Immunosorbents, Immunosuppression Therapy, Lymphocyte Culture Test, Mixed, Male, Mice, Inbred BALB C, Pregnancy, Pregnancy Proteins, Thymidine, Tritium, Mice
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