Cited by 220Reproductive System and PregnancyPregnancy-related medical researchPregnancy and preeclampsia studies

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IDENTIFICATION OF PLACENTAL PROTEIN 14 AS AN IMMUNOSUPPRESSIVE FACTOR IN HUMAN REPRODUCTION

Bolton, A.E., Clough, K.J., Stoker, R.J., Pockley, A.G., Mowles, E.A., Westwood, O.M.R., Chapman, M.G.·1987·The Lancet

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Abstract

Extracts of human decidual tissue obtained in the first trimester of pregnancy showed potent suppressive activity in mixed lymphocyte cultures. These extracts contained substantial amounts of the decidual protein PP14. Purified PP14 also exhibited in vitro immunosuppressive activity, and such activity in decidual extract and purified PP14 preparations was removed by treatment with a monoclonal anti-PP14 antibody-based immunoadsorbent. PP14 was present in seminal plasma, which also exhibited immunosuppressive activity that could be reduced, but not removed, by the immunoadsorbent. PP14 may be an important immunomodulator in the human reproductive system.

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Authors: Bolton, A. E., Clough, K. J., Stoker, R. J., Pockley, A. G., Mowles, E. A., Westwood, O. M. R., & Chapman, M. G.
ORCID: Pockley, A.G.
Chapman, M.G.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1987-03
Volume: 329
Issue: 8533
Pages: 593-595
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(87)90235-2
OpenAlex: W1998710143
Cited by: 220
References: 30
Citations by year: 2025: 1 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
FWCI: 3.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: placental protein 14, immunosuppression, decidua, first trimester, mixed lymphocyte reaction, seminal plasma, immunoadsorbent, immunomodulation, human reproduction
MeSH terms: Glycodelin, Animals, Antibodies, Monoclonal, Endometrium, Female, Glycoproteins, Humans, Immunosorbents, Immunosuppression Therapy, Lymphocyte Culture Test, Mixed, Male, Mice, Inbred BALB C, Pregnancy, Pregnancy Proteins, Thymidine, Tritium, Mice

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IDENTIFICATION OF PLACENTAL PROTEIN 14 AS AN IMMUNOSUPPRESSIVE FACTOR IN HUMAN REPRODUCTION

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