The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A ROLE FOR INSULIN IN THE AETIOLOGY AND COURSE OF HYPERTENSION?
Open accessAbstract
It is proposed that abnormalities of glucose and insulin metabolism have a role in both the aetiology and the clinical course of hypertension. There is resistance to insulin-stimulated glucose uptake in patients with hypertension, which is associated with glucose intolerance and hyperinsulinaemia. Hyperinsulinaemia could contribute to hypertension by stimulating the activity of the sympathetic nervous system and kidney sodium and volume reabsorption. Glucose intolerance and hyperinsulinaemia have been identified as risk factors for coronary artery disease, and their presence may help explain why the frequency of this disease has not been reduced by treatment of hypertension. The fact that several antihypertensive drugs deleteriously affect glucose, insulin, and lipid metabolism makes it even more important to consider these factors in the treatment of high blood pressure.
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Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465
Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man
Rowe, J. W., Young, J. B., Minaker, K. L., Stevens, A. L., Pallotta, J., & Landsberg, L. (1981) · Diabetes · doi:10.2337/diab.30.3.219 · Cited by 1,143
Cited by
Glucocorticoids and insulin resistance: old hormones, new targets
ANDREWS, R. C., & WALKER, B. R. (1999) · Clinical Science · doi:10.1042/cs0960513 · Cited by 731
Adiposity, Fat Distribution, and Cardiovascular Risk
Peiris, A. N., Sothmann, M. S., Hoffmann, R. G., Hennes, M. I., Wilson, C. R., Gustafson, A. B., & Kissebah, A. H. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-110-11-867 · Cited by 423
Racial Differences in the Relation between Blood Pressure and Insulin Resistance
Saad, M. F., Lillioja, S., Nyomba, B. L., Castillo, C., Ferraro, R., De Gregorio, M., Ravussin, E., Knowler, W. C., Bennett, P. H., Howard, B. V., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103143241105 · Cited by 421
Macfarlane, D. P., Forbes, S., & Walker, B. R. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0054 · Cited by 385
Hypertension, Diabetes Mellitus, and Insulin Resistance The Role of Intracellular Magnesium
Paolisso, G. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00342-1 · Cited by 300
Metadata
- Authors
- Reaven, G., & Hoffman, B.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1987-08
- Volume
- 330
- Issue
- 8556
- Pages
- 435-437
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2048253618
- Cited by
- 292
- References
- 2
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: A ROLE FOR INSULIN IN THE AETIOLOGY AND COURSE OF HYPERTENSION? https://app.cochat.ai/papers/10.1016/s0140-6736(87)90968-8
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- Reaven, G., & Hoffman, B. (1987). A ROLE FOR INSULIN IN THE AETIOLOGY AND COURSE OF HYPERTENSION? The Lancet. https://doi.org/10.1016/s0140-6736(87)90968-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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