Cytomegalovirus reactivation and tumour necrosis factor
Abstract
Tumour necrosis factor-alpha (TNF) stimulates cytomegalovirus (CMV) activity in a transfected human monocytic cell line. We assessed whether this finding is relevant in vivo by evaluating the frequency of active CMV infection in patients with diseases that enhance plasma TNF. In septic disease, peripheral blood mononuclear cells of almost all patients studied were positive for CMV. Furthermore, CMV antigenaemia and enhanced plasma TNF occurred in many patients with liver cirrhosis, common variable immunodeficiency, and B-cell chronic lymphocytic leukaemia. Thus, TNF may have a central role in CMV reactivation.
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If antioxidant molecules are depleted in T cells, cytokine production can become uncontrolled, potentially resulting in an inflammatory environment that is known to reactivate CMV.
“Finally, if antioxidant molecules are depleted in T cells, then cytokine production, can become uncontrolled (Michalek et al. 2012), potentially resulting in an inflammatory environment that is also known to reactivate CMV (Docke et al. 1994; Prosch et al. 1995; Stein et al. 1993).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Docke et al. 1994
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References 10 · Cited by 268
- Authors
- Döcke, W. D., Fietze, E., Syrbe, U., von Baehr, R., Volk, H. D., Prösch, S., Kimel, V., Krüger, D. H., Zuckermann, H., & Klug, C.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Döcke, W.D.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 343
- Issue
- 8892
- Pages
- 268-269
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2018990797
- Cited by
- 268
- References
- 10
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 4 · 2012: 14
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- cytomegalovirus reactivation, TNF-α, sepsis, liver cirrhosis, common variable immunodeficiency, chronic lymphocytic leukemia, peripheral blood mononuclear cells, viral reactivation
- MeSH terms
- Adolescent, Adult, Antigens, Viral, Cytomegalovirus Infections, Cytomegalovirus, Female, Follow-Up Studies, Humans, Immunohistochemistry, Leukocytes, Mononuclear, Liver Cirrhosis, Male, Middle Aged, Recurrence, Tumor Necrosis Factor-alpha, Virus Activation, Leukemia, Lymphocytic, Chronic, B-Cell, Interleukin-6, Case-Control Studies, Polymerase Chain Reaction, Common Variable Immunodeficiency, Sepsis
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