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The relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour
Abstract
Proliferation and adhesion of mouse (MC3T3-E1) osteoblastic cells and primary human osteoblastic cells were carried out on Ti6Al4V titanium alloy samples with varied surface roughnesses. Mechanically or manually polished surfaces were prepared to produce respectively non-oriented or oriented residual polishing grooves. Sand-blasted surfaces were prepared using 500 microm or 3 mm alumina particles. Surface roughness parameters showed a negative correlation in comparison to proliferation and adhesion parameters. X-ray microprobe chemical surface microanalysis showed complete disturbance of the surface element composition of the Ti6Al4V alloy following sand-blasting treatment. An AlOx-enriched layer was observed on sample surfaces. This may lead to the suspicion that the concomittant effect of surface roughness amplitude and AlOx surface concentration has an effect on osteoblastic cell proliferation and adhesion. These findings show the significance of chemical surface analysis after any surface treatment of titanium-based implants before any biological use.
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Cited by
Mediation of biomaterial-cell interactions by adsorbed proteins: a review
Wilson, C. J., Clegg, R. E., Leavesley, D. I., & Pearcy, M. J. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1 · Cited by 1,696
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082
Paital, S. R., & Dahotre, N. B. (2009) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2009.05.001 · Cited by 673
Topography effects of pure titanium substrates on human osteoblast long-term adhesion
ANSELME, K., & BIGERELLE, M. (2005) · Acta Biomaterialia · doi:10.1016/j.actbio.2004.11.009 · Cited by 314
Self-citationCell/Material Interfaces: Influence of Surface Chemistry and Surface Topography on Cell Adhesion
Anselme, K., Ploux, L., & Ponche, A. (2010) · Journal of Adhesion Science and Technology · doi:10.1163/016942409x12598231568186 · Cited by 291
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Metadata
- Authors
- Anselme, K., Linez, P., Bigerelle, M., Le Maguer, D., Le Maguer, A., Hardouin, P., Hildebrand, H. F., Iost, A., & Leroy, J. M.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 21
- Issue
- 15
- Pages
- 1567-1577
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2008124574
- Cited by
- 413
- References
- 0
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anselme, K., Linez, P., Bigerelle, M., Le Maguer, D., Le Maguer, A., Hardouin, P., Hildebrand, H. F., Iost, A., & Leroy, J. M. (2000). The relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour. Biomaterials. https://doi.org/10.1016/s0142-9612(00)00042-9
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