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Development and applications of injectable poly(ortho esters) for pain control and periodontal treatment
Abstract
Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing procedure. When molecular weights are limited to < 5 kDa, such materials are directly injectable using a needle size no larger than 22 gauge. Somewhat hydrophilic polymers can be produced by using the diketene acetal 3,9-diethylidene-2,4,8,10-tetraoxaspiro[5.5]undecane and triethylene glycol (TEG), while hydrophobic materials can be produced by using the diketene acetal and 1,10-decanediol. Molecular weight can be reproducibly controlled by using an excess of the diol, or by use of an alcohol that acts as a chain-stopper. Erosion rates can be controlled by varying the amount of latent acid incorporated into the polymer backbone. Toxicology studies using the TEG polymer have been completed and have shown that the polymer is non-toxic. Toxicology studies using the decanediol polymer are underway. Development studies using the TEG polymer aimed at providing a sustained delivery of an analgesic agent to control post-surgical pain are under development and human clinical trials using the decanediol polymer for the treatment of periodontitis are also underway.
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Poly(ortho esters) based injectable polymer has been reported for use in pain control and periodontal treatment.
“Poly(ortho esters) based injectable polymer has also been reported (Heller et al., 2002) for use in pain control and periodontal treatment.”
From Biodegradable synthetic polymers for tissue engineering (2003) · cites this paper as Heller et al., 2002
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Research works printed but not linked: 12
- Heller, 1980, Preparation of poly(ortho esters) by the reaction of ketene acetals and diols, J Polym Sci Polym Lett Ed, 18, 82, 10.1002/pol.1980.130180907 · DOI
- Ng, 1992, Poly (ortho esters) by the addition of diols to a diketene acetal, Macromol Synth, 11, 23
- Heller, 1993, Poly(ortho esters), Adv Polym Sci, 107, 41, 10.1007/BFb0027551 · DOI
- Ng, 1997, Synthesis and erosion studies of self-catalyzed poly(ortho ester)s, Macromolecules, 30, 770, 10.1021/ma9610626 · DOI
- Schwach-Abbellaoui, 1999, Hydrolysis and erosion studies of autocatalyzed poly(ortho esters) containing lactoyl–lactyl acid dimers, Macromolecules, 32, 301, 10.1021/ma981517m · DOI
- Heller, 2002, Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery, J Controlled Release, 78, 133, 10.1016/S0168-3659(01)00482-5 · DOI
- Schwach-Abdellaoui K, Heller J, Barr J, Gurny R. Control of molecular weight for auto-catalyzed poly(ortho esters) obtained by polycondensation reaction. Int J Polym Anal Charact, in press. · DOI
- Ng, 2000, Development of a poly(ortho ester) prototype with latent acid in the polymer backbone for 5-fluorouracil delivery, J Controlled Release, 65, 367, 10.1016/S0168-3659(99)00218-7 · DOI
- Schwach-Abbellaoui K, Monti A, Barr J, Heller J, Gurny R. Optimization of a novel bioerodible device based on autocatalyzed poly(ortho ester) for controlled delivery of tetracycline to periodontal pocket. Biomaterials, in press.
- Schwach-Abdellaoui, 2000, Local delivery of antimicrobial agents for the treatment of periodontal diseases, Eur J Biopharm, 50, 83, 10.1016/S0939-6411(00)00086-2 · DOI
- Schwach-Abbellaoui K, Vivien-Castioni N, Loup PJ, Baehni P, Mombelli A, Barr J, Heller J, Gurny R. Bioerodible injectable poly(ortho ester) for tetracycline delivery to periodontal poicket: Preliminary trial in humans, http:/www.pharmsci.org/, in press
- van Winkelhoff, 1996, Periodontal infections and treatment, J Parodontol Implantol Orale, 15, 219
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Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765
“Poly(ortho esters) based injectable polymer has also been reported (Heller et al., 2002) for use in pain control and periodontal treatment.”
BackgroundIn situ forming parenteral drug delivery systems: an overview
Packhaeuser, C. B., Schnieders, J., Oster, C. G., & Kissel, T. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.003 · Cited by 413
Metadata
- Authors
- Heller, J., Barr, J., Ng, S. Y., Shen, H.-R., Schwach-Abdellaoui, K., Gurny, R., Vivien-Castioni, N., Loup, P. J., Baehni, P., & Mombelli, A.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Heller, J
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 23
- Issue
- 22
- Pages
- 4397-4404
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2027555154
- Cited by
- 33
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- poly(ortho esters), injectable polymers, low glass transition temperature, triethylene glycol, 1,10-decanediol, hydrophilic and hydrophobic polymers, molecular weight control, chain stopper, sustained drug release, postoperative pain, periodontitis treatment, polymer toxicity
- MeSH terms
- Anesthetics, Local, Animals, Biocompatible Materials, Bupivacaine, Dogs, Drug Carriers, Fatty Alcohols, Gingiva, Glass, Humans, Injections, Models, Chemical, Magnetic Resonance Spectroscopy, Pain, Periodontal Diseases, Polyesters, Polyethylene Glycols, Polymers, Solvents, Temperature, Tetracycline, Time Factors, Rats, Sprague-Dawley, Rats
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