The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Stereological evaluation of vascular adaptations in human placental villi to differing forms of hypoxic stress
Abstract
The aim was to determine whether the fetal vasculature of the human placenta adapts in a uniform manner to different forms of hypoxic stress. Stereological analyses were performed on the intermediate and terminal villi of placentae obtained from each of the following conditions; high altitude (up to 2800 m), maternal iron-deficiency anaemia and pre-eclampsia. These conditions were taken to represent hypoxic, anaemic and ischaemic hypoxia, respectively. In each situation, there was a trend for the volume fraction of the fetal capillaries to be higher than in the controls, although the differences were statistically significant only for the cases of hypoxic and anaemia hypoxia. This was due, in part, to capillaries being of larger diameter. Evidence for capillary proliferation was inconsistent. At high altitude there was a trend for the capillary length density to be raised, but there was no change in the ratio of capillary:villous length. In both maternal anaemia and pre-eclampsia the capillary length density remained constant, but the ratio of capillary:villous length was significantly raised in the former. These results suggest that dilatation of the capillary sinusoids, with accompanying thinning of the villous membrane, is the principal adaptation to hypoxia under the conditions studied.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In all high-altitude populations studied to date, there is increased villous vascularisation as a result of increased vasculogenesis and angiogenesis (7, 78, 176, 509, 532).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [78]
In the citing paper
“This is achieved through selective dilation of the capillary sinusoids at the vasculosyncytial membranes (78), a mechanism that increases placental diffusing capacity but has minimal effects on extracorporeal blood volume and the load on the fetal heart.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [78]
Citations
Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Fox, H., & Elston, C. W. (1978) · PubMed · Cited by 621
The impact of recent stereological advances on quantitative studies of the nervous system
Brændgaard, H., & Gundersen, H. J. G. (1986) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(86)90112-3 · Cited by 501
Jackson, M., Carney, E. W., Lye, S. J., & Ritchie, J. W. K. (1994) · Placenta · doi:10.1016/0143-4004(94)90002-7 · Cited by 179
The fetal vascularisation of term human placental villi
Kaufmann, P., Bruns, U., Leiser, R., Luckhardt, M., & Winterhager, E. (1985) · Anatomy and Embryology · doi:10.1007/bf00316301 · Cited by 170
Chorangiosis. An important placental sign of neonatal morbidity and mortality.
Altshuler, G. P. (1984) · PubMed · Cited by 153
Classification of human placental villi
Kaufmann, P., Sen, D. K., & Schweikhart, G. (1979) · Cell and Tissue Research · doi:10.1007/bf00234852 · Cited by 147
Reshetnikova, O. S., Burton, G. J., & Milovanov, A. P. (1994) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(94)90402-2 · Cited by 127
Self-citationMayhew, T. M., & Burton, G. J. (1988) · Placenta · doi:10.1016/0143-4004(88)90001-x · Cited by 114
Self-citationJackson, M. R., Mayhew, T. M., & Haas, J. D. (1987) · Placenta · doi:10.1016/0143-4004(87)90077-4 · Cited by 112
Placental anatomy and diffusing capacity in guinea pigs following long-term maternal hypoxia
Bacon, B. J., Gilbert, R. D., Kaufmann, P., Smith, A. D., Trevino, F. T., & Longo, L. D. (1984) · Placenta · doi:10.1016/s0143-4004(84)80002-8 · Cited by 96
The effects of maternal vascular pressure on the dimensions of the placental capillaries
Karimu, A. L., & Burton, G. J. (1994) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1994.tb13011.x · Cited by 82
Self-citationReshetnikova, O. S., Burton, G. J., & Васильевна, Т. О. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90330-5 · Cited by 82
Self-citationThree-Dimensional Representation of the Fetal Vessel System in the Human Placenta
Kaufmann, P., Luckhardt, M., & Leiser, R. (1988) · Springer eBooks · doi:10.1007/978-1-4615-8109-3_9 · Cited by 81
Histomorphometry of the human placenta in maternal preeclampsia
Teasdale, F. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(85)80170-8 · Cited by 79
Pijnenborg, R. (1994) · Reproductive Medicine Review · doi:10.1017/s0962279900000776 · Cited by 70
Teasdale, F. (1987) · Placenta · doi:10.1016/0143-4004(87)90015-4 · Cited by 68
Anthony, F. W., Wheeler, T., Elcock, C. L., Pickett, M. A., & Thomas, E. J. (1994) · Placenta · doi:10.1016/s0143-4004(05)80424-2 · Cited by 66
Mayhew, T. M., Wadrop, E., & Simpson, R. A. (1994) · PubMed · Cited by 51
Formation of vasculo-syncytial membranes in the human placenta.
Burton, G. J., & Tham, S. W. (1992) · PubMed · Cited by 46
Self-citationKarimu, A. L., & Burton, G. J. (1994) · Reproduction · doi:10.1530/jrf.0.1020447 · Cited by 35
Self-citationMaternal oxygen supply as a regulator of fetal placental capillarisation
Scheffen, I., Philippens, L., Kaufmann, P., Leiser, R., & Mironov, V. (1989) · Placenta · doi:10.1016/0143-4004(89)90147-1 · Cited by 7
Effects of High Altitude on the Vascularization of Terminal Villi in Human Placentae
Jackson, M. R., Mayhew, T. M., & Haas, J. D. (1988) · Springer eBooks · doi:10.1007/978-1-4615-8109-3_26 · Cited by 6
Chorangiosis: Clinical correlations and pathological background
Soma, H., Watanabe, Y., & Hata, T. (1994) · Placenta · doi:10.1016/0143-4004(94)90171-6 · Cited by 1
Research works printed but not linked: 3
- Karimu, 1994, Compliance of the human placental villous membrane at term; the concept of the feto-placental unit as an autoregulating gas exchange system, Trophoblast Research, 8, 541
- Reshetnikova, 1994, Human placental chorangioma at high altitude, Journal of Anatomy, 185, 223
- Reshetnikova, O. S., Burton, G. J., Milovanov, A. P. et al (in press) Increased incidence of placental chorangioma in high altitude pregnancies; hypobaric hypoxia as a possible aetiological factor. American Journal of Obstetrics and Gynecology.
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Self-citationDevelopment of the placental villous tree and its consequences for fetal growth
Kingdom, J. C., Huppertz, B., Seaward, G. R., & Kaufmann, P. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00423-1 · Cited by 605
“[74] Burton GJ, Reshetnikova OS, Milovanov AP, Teleshova OV.”
BackgroundOxygen and placental villous development: Origins of fetal hypoxia
Kingdom, J. C., & Kaufmann, P. (1997) · Placenta · doi:10.1016/s0143-4004(97)90000-x · Cited by 581
Jansson, T., & Powell, T. L. (2007) · Clinical Science · doi:10.1042/cs20060339 · Cited by 542
Aspects of Human Fetoplacental Vasculogenesis and Angiogenesis. II. Changes During Normal Pregnancy
Kaufmann, P., Mayhew, T. M., & Jones, D. S. (2003) · Placenta · doi:10.1016/j.placenta.2003.10.009 · Cited by 450
Metadata
- Authors
- Burton, G. J., Reshetnikova, O. S., Milovanov, A. P., & Teleshova, O. V.
- Affiliations
- University of Cambridge (GB)
- Luhansk State Medical University (UA)
- Corresponding author
- Burton, G.J.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 17
- Issue
- 1
- Pages
- 49-55
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W1967702415
- Cited by
- 149
- References
- 24
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 7
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Physiology (medical) › High Altitude and Hypoxia
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- placental villi, fetal vasculature, hypoxic stress, high altitude, preeclampsia, capillary density, capillary dilation, stereology
- MeSH terms
- Altitude, Hypoxia, Capillaries, Female, Fetus, Humans, Male, Placenta, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Anemia, Iron-Deficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
