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Cited by 112Pregnancy and preeclampsia studiesBirth, Development, and HealthHigh Altitude and Hypoxia

Morphometric studies on villi in human term placentae and the effects of altitude, ethnic grouping and sex of newborn

Jackson, Moira R., Mayhew, T.M., Haas, J.D.·1987·Placenta
DOI 10.1016/0143-4004(87)90077-4
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Abstract

Stereological methods were used to test whether or not altitudinal, ethnic and sex differences in birthweight in Bolivia are associated with differences in placental morphology. Estimates of the volumes, surface areas, lengths and diameters of villi and of fetal capillaries were obtained by analysing paraffin sections of tissue. The average highland placenta contains villi of smaller overall volume, surface area and length. These villi possess a less voluminous fetal vascular space, and the capillaries are smaller in mean diameter. The average Amerindian placenta has longer but thinner capillaries than the average placenta delivered by non-indigenous women. Altitude and ethnic grouping interact to have an effect on total villous length, whilst ethnic grouping and sex interact to influence fetal capillary length. These structural differences are discussed in the context of their likely impact on placental functioning, notably on exchange by passive diffusion.

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Crossref · 10.1016/0143-4004(87)90077-4

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  • Under limiting conditions such as pregnancy at high altitude, changes in surface area or membrane thickness may be adaptive responses to facilitate exchange.

    “However, under limiting conditions, such as pregnancy at high altitude, changes in surface area or membrane thickness may be considered adaptive responses to facilitate exchange (275, 369, 458).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [275]

  • The fetal capillaries are longer and thinner in Andean than European/Mestizo placentas.

    “The fetal capillaries are also longer and thinner in Andean than European/Mestizo placentas (275).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [275]

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Authors
Jackson, M. R., Mayhew, T. M., & Haas, J. D.
Affiliations
  • University of Aberdeen (GB)
  • Cornell University (US)
Corresponding author
Jackson, Moira R.
ORCID
Haas, J.D.
Venue
Placenta
Publisher
Elsevier BV
Published
1987-09
Volume
8
Issue
5
Pages
487-495
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/0143-4004(87)90077-4
OpenAlex
W1990290426
Cited by
112
References
25
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 3 · 2012: 9
FWCI
5.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
Keywords
placental villi, placental morphology, altitude, ethnic differences, Amerindian populations, sex differences, birth weight, fetal capillaries, placental exchange, passive diffusion, term placenta, Bolivia
MeSH terms
Acclimatization, Altitude, Bolivia, Capillaries, Chorionic Villi, Ethnicity, Female, Humans, Indians, South American, Infant, Newborn, Male, Pregnancy, Sex Factors

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