A comparison of the effect of high-dose methylprednisolone with conventional-dose prednisolone in acute lymphoblastic leukemia patients with randomization.
Abstract
In this preliminary study the efficacy of high-dose methylprednisolone (HDMP) during remission-induction chemotherapy was evaluated on 166 children with acute lymphoblastic leukemia (ALL). The St. Jude Total Therapy Study XI protocol with minor modifications was used in this trial. Patients were randomized into two groups. Group A received conventional-dose (2 mg/kg/day orally) prednisolone, and group B received high-dose methylprednisolone (HDMP, Prednol-L, 900-600 mg/m2 orally) during remission-induction chemotherapy. Complete remission was achieved in 97% of the children. For the 80 patients who were followed up for 3 years, median follow-up was 44 (range 5-60) months and the 3-year event-free survival (EFS) rate was 68.5%) overall, 58.6% in group A and 78.4% in group B. The EFS among patients in group B was significantly higher than in group A (p=0.05). When we compared the 3-year EFS of groups A and B in the high-risk groups and high-risk subgroups with white blood cell (WBC) counts > or = 50 x 10(9)/l and age > or = 10 years, the survival rates were 45% versus 77.2%, 33% versus 78% and 45% versus 89%, respectively. During the follow-up of 162 patients, relapses were significantly higher in group A. Bone marrow relapses in 162 patients, and also in a subgroup of patients > or = 10 years of age were significantly higher in group A. These results suggest that HDMP during remission-induction chemotherapy improves long-term EFS, particularly for high-risk patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Current treatment protocols of glucocorticoids for hematological cancers are based on the administration of high glucocorticoid doses.
“The current treatment protocols of GCs for hematological cancers are based on the administration of high GC doses [51].”
From Fabrication Principles and Their Contribution to the Superior In Vivo Therapeutic Efficacy of Nano-Liposomes Remote Loaded with Glucocorticoids (2011) · cites this paper as [51]
Cites
Rationale for the use of alternating non-cross-resistant chemotherapy.
Goldie, J. H., Coldman, A. J., & Ga, G. (1982) · PubMed · Cited by 551 · see citing works
Secondary Acute Myeloid Leukemia in Children Treated for Acute Lymphoid Leukemia
Pui, C., Behm, F. G., Raimondi, S. C., Dodge, R. K., George, S. L., Rivera, G. K., Mirro, J., Kalwinsky, D. K., Dahl, G. V. H., Murphy, S. B., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210302 · Cited by 439 · see citing works
Clavell, L. A., Gelber, R. D., Cohen, H. J., Hitchcock‐Bryan, S., Cassady, J. R., Tarbell, N. J., Blattner, S. R., Tantravahi, R. V., Leavitt, P., & Sallan, S. E. (1986) · New England Journal of Medicine · doi:10.1056/nejm198609113151101 · Cited by 417 · see citing works
Rivera, G. K., Pui, C., Abromowitch, M., Mirro, J., Ochs, J., Look, A. T., Murphy, S. B., Dahl, G. V. H., Kalwinsky, D. K., Simone, J. V., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)90733-6 · Cited by 376 · see citing works
Rivera, G. K., Pinkel, D. P., Simone, J. V., Hancock, M. L., & Crist, W. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310283291801 · Cited by 261 · see citing works
Results and Significance of Six Randomized Trials in Four Consecutive ALL-BFM Studies
Riehm, H., Gadner, H., Henze, G., Kornhuber, B., Lampert, F., NIETHAMMER, D., Reiter, A., & Schellong, G. (1990) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-74643-7_81 · Cited by 190 · see citing works
Leukemia Research: Advances in Cell Biology and Treatment
Miller, D. R. (1985) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1985.02140040087034 · Cited by 115 · see citing works
Glucocorticoid receptors in subpopulations of childhood acute lymphocytic leukemia.
Yarbro, G. K., Lippman, M. E., Johnson, G. E., & Leventhal, B. G. (1977) · PubMed · Cited by 80 · see citing works
The effect of massive prednisone and prednisolone therapy on acute leukemia and malignant lymphomas
Ranney, H. M., & Gellhorn, A. (1957) · The American Journal of Medicine · doi:10.1016/0002-9343(57)90096-7 · Cited by 79 · see citing works
Poor prognosis in negro children with acute lymphocytic leukemia
Walters, T. R., Bushore, M., & Simone, J. V. (1972) · Cancer · doi:10.1002/1097-0142(197201)29:1 · Cited by 76 · see citing works
Pui, C., Simone, J. V., Hancock, M., We, E., Dl, W., Wp, B., Dahl, G. V. H., Rk, D., Ochs, J., & Abromowitch, M. (1992) · PubMed · Cited by 74 · see citing works
Glucocorticoid receptors in childhood acute lymphocytic leukemia.
Costlow, M. E., Pui, C., & Dahl, G. V. H. (1982) · PubMed · Cited by 71 · see citing works
Spurbeck, J. L., Carlson, R. O., Allen, J. E., & Dewald, G. W. (1988) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(88)90312-3 · Cited by 68 · see citing works
Eliason, J. F. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041280214 · Cited by 52 · see citing works
Cortisone Action on Serum Colony-Stimulating Factor and Bone Marrow in Vitro Colony-Forming Cells
Metcalf, D. (1969) · Experimental Biology and Medicine · doi:10.3181/00379727-132-34222 · Cited by 49 · see citing works
Dahl, G. V. H., Rivera, G. K., Look, A. T., Hustu, H. O., Kalwinsky, D. K., Abromowitch, M., Mirro, J., Ochs, J., Murphy, S. B., & Dodge, R. K. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.7.1015 · Cited by 44 · see citing works
Critical Evaluation of Massive Steroid Therapy of Acute Leukemia
Shanbrom, E., & Miller, S. (1962) · New England Journal of Medicine · doi:10.1056/nejm196206282662603 · Cited by 44 · see citing works
Cetin, M., Yetgin, S., Kara, A., Tuncer, A. M., Günay, L. M., Gümrük, F., & Gürgey, A. (1994) · PubMed · Cited by 43 · see citing works
Self-citationSuccessful treatment of refractory anemia with high‐dose methylprednisolone
Motoji, T., Teramura, M., Takahashi, M., Oshimi, K., Okada, M., Kusakabe, K., & Mizoguchi, H. (1990) · American Journal of Hematology · doi:10.1002/ajh.2830330103 · Cited by 43 · see citing works
MASSIVE PREDNISONE AND PREDNISOLONE THERAPY IN LEUKEMIA AND LYMPHOMAS IN THE ADULT††
Hill, J. M., Marshall, G. J., & Falco, D. (1956) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1956.tb00846.x · Cited by 33 · see citing works
Hiçsönmez, G., Ozsoylu, S. N., & Tuncer, A. M. (1991) · Leukemia Research · doi:10.1016/0145-2126(91)90020-t · Cited by 30 · see citing works
Hiçsönmez, G., Ozsoylu, S. N., Am, T., Ertürk, G., Özbek, N., & Karadeniz, N. (1991) · PubMed · Cited by 26 · see citing works
Self-citationHiçsönmez, G., Onat, N., Albayrak, D., Yetgin, S., & Ozsoylu, S. N. (1991) · Pediatric Hematology and Oncology · doi:10.3109/08880019109033448 · Cited by 25 · see citing works
Self-citationGlucocorticoid receptors in human leukemias and related diseases
Thompson, E. B., Smith, J. R., Bourgeois, S., & Harmon, J. M. (1985) · Journal of Molecular Medicine · doi:10.1007/bf01733111 · Cited by 23 · see citing works
Tuncer, A. M., Hiçsönmez, G., Ertürk, G., Gümrük, F., Albayrak, D., & Oguz, H. (1992) · Leukemia Research · doi:10.1016/0145-2126(92)90010-5 · Cited by 21 · see citing works
Self-citationHiçsönmez, G., Karadeniz, N., Zamani, V. P., Tuncer, A. M., Gümrük, F., Ertürk, G., Gürgey, A., & Ozsoylu, S. N. (1992) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1992.tb01588.x · Cited by 21 · see citing works
Self-citationHiçsönmez, G., Ozsoylu, S. N., Gürgey, A., Zamani, V. P., & İrken, G. (1989) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1989.tb01478.x · Cited by 21 · see citing works
Self-citationSchüler, D., Szende, B., Borsi, J., Marton, T., Bocsi, J., Magyarosy, E., Koós, R., & Csóka, M. (1994) · Pediatric Hematology and Oncology · doi:10.3109/08880019409141811 · Cited by 20 · see citing works
Cetin, M., Hiçsönmez, G., Tuncer, A. M., Kansu, E., & Canpynar, H. (1996) · PubMed · Cited by 20 · see citing works
Ryalls, M. R., Pinkerton, R., Meller, S. T., Talbot, D., & McElwain, T. J. (1992) · Medical and Pediatric Oncology · doi:10.1002/mpo.2950200206 · Cited by 18 · see citing works
Poor prognosis of childhood acute lymphoblastic leukaemia.
Hiçsönmez, G., Ozsoylu, S. N., Yetgin, S., Zamani, V. P., & Gürgey, A. (1983) · BMJ · doi:10.1136/bmj.286.6375.1437-c · Cited by 16 · see citing works
Self-citationHiçsönmez, G., Gümrük, F., Zamani, P., Tuncer, M. A., Yetgin, S., Gürgey, A., Atahan, L., & Ozsoylu, S. N. (1997) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1997.tb01406.x · Cited by 14 · see citing works
Self-citationHiçsönmez, G., Ozsoylu, S. N., Onat, N., Zamani, V. P., Gümrük, F., & Tuncer, M. A. (1994) · Medical and Pediatric Oncology · doi:10.1002/mpo.2950220114 · Cited by 13 · see citing works
Self-citationPrognosis in 262 Turkish children with acute lymphocytic leukemia
Hiçsönmez, G., Ozsoylu, S. N., Yetgin, S., Zamani, Gürgey, A., & Atahan, I. L. (1982) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.1982.4106 · Cited by 5 · see citing works
Self-citationRecombinant factor VIII concentrate
Walker, I., & Poon, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)90190-e · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Acute Lymphoblastic Leukemia in Children
Hunger, S. P., & Mullighan, C. G. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1400972 · Cited by 2,247 · see citing works
Acute lymphoblastic leukemia in children
Pui, C. (2000) · Current Opinion in Oncology · doi:10.1097/00001622-200001000-00002 · Cited by 169 · see citing works
Avnir, Y., Turjeman, K., Tulchinsky, D., Sigal, A., Kizelsztein, P., Tzemach, D., Gabizon, A., & Barenholz, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025721 · Cited by 72 · see citing works
Two booster dose hepatitis B virus vaccination in patients with leukemia
Yetgin, S., Tunç, B., Koç, A., Toksoy, H. B., Ceyhan, M., & Kanra, G. (2001) · Leukemia Research · doi:10.1016/s0145-2126(00)00101-6 · Cited by 38 · see citing works
Self-citationAkyay, A., Olcay, L., Sezer, N., & Sönmez, Ç. (2014) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000067 · Cited by 37 · see citing works
Self-citationAcute and long-term neurologic complications in children with acute lymphoblastic leukemia
Aytaç, S., Yetgin, S., & Tavil, B. (2006) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2006.2587 · Cited by 37 · see citing works
Self-citationHiçsönmez, G. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.05.015 · Cited by 36 · see citing works
Yetgin, S., Tuncer, M. A., Çetın, M., Gümrük, F., Yenicesu, İ., Tunç, B., Öner, A. F., Toksoy, H. B., Koç, A., Aslan, D., et al. (2003) · Leukemia · doi:10.1038/sj.leu.2402673 · Cited by 36 · see citing works
Self-citationYetgin, S., Olgar, Ş., Aras, T., Çetin, M., Düzova, A., Beylergil, V., Akhan, O., Oĝuz, O., & Saraçbaşı, O. (2004) · American Journal of Hematology · doi:10.1002/ajh.20146 · Cited by 31 · see citing works
Self-citationAlikaşifoğlu, A., Yetgin, S., Çetin, M., Tuncer, M. A., Gümrük, F., Gürgey, A., & Yordam, N. (2005) · American Journal of Hematology · doi:10.1002/ajh.20438 · Cited by 30 · see citing works
Self-citationAkyüz, C., Yarış, N., Kutluk, M. T., & Büyükpamukçu, M. (2001) · Pediatric Hematology and Oncology · doi:10.1080/088800101750059855 · Cited by 29 · see citing works
Can Renal Leukemic Infiltration Cause Hypertension in Children?
Olgar, Ş., Yetgin, S., Çetin, M., & Aras, T. (2006) · Journal of Pediatric Hematology/Oncology · doi:10.1097/01.mph.0000212990.64435.b9 · Cited by 23 · see citing works
Self-citationOlgar, E., Yetgin, S., etin, M., Aras, T., & Akhan, O. (2005) · Journal of Pediatric Hematology/Oncology · doi:10.1097/01.mph.0000161271.68054.b9 · Cited by 20 · see citing works
Self-citationMedical neglect of a child: challenges for pediatricians in developing countries
Ertem, İ., Bingoler, B. E., Ertem, M., Uysal, Z., & Gözdaşoğlu, S. (2002) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00349-6 · Cited by 16 · see citing works
Yetgin, S., Çetin, M., & Gürgey, A. (2003) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/1042819021000055048 · Cited by 15 · see citing works
Self-citationKoç, A., Ayçiçek, A., Özdemir, Z. C., Söker, M., & Varma, M. (2012) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e318271f43f · Cited by 13 · see citing works
Acute and long-term neurological complications in children with acute lymphoblastic leukemia
Rahman, A., Mannan, M. A., & Sadeque, S. (1970) · Bangladesh Medical Research Council Bulletin · doi:10.3329/bmrcb.v34i3.1858 · Cited by 11 · see citing works
Yetgin, S., Özyürek, E., Aslan, D., & Çetin, M. (2004) · Pediatric Hematology and Oncology · doi:10.1080/08880010490440482 · Cited by 11 · see citing works
Self-citationYetgin, S., & Ozsoylu, S. N. (2007) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3180335be0 · Cited by 9 · see citing works
Self-citationÖzbek, N. Y., Yetgin, S., & Tuncer, A. M. (1998) · Pediatric Hematology and Oncology · doi:10.3109/08880019809018316 · Cited by 8 · see citing works
Self-citationTavil, B., Çetin, M., Tuncer, M. A., Gümrük, F., Yüce, A., Demır, H., Aytaç, S., Kuşkonmaz, B., Ünal, Ş., & Yetgin, S. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00079.x · Cited by 7 · see citing works
Self-citationUçkan, D., Yetgin, S., Çetın, M., Özyürek, E., Okur, H., Aslan, D., & Tuncer, M. A. (2003) · Clinical & Laboratory Haematology · doi:10.1046/j.1365-2257.2003.00475.x · Cited by 6 · see citing works
Self-citationErduran, E., Tekelioğlu, Y., Karakaş, T., Gedik, Y., & Mert, F. M. (2006) · Pediatric Hematology and Oncology · doi:10.1080/08880010600857053 · Cited by 6 · see citing works
Tunç, B., Öner, A. F., & Hiçsönmez, G. (2002) · Leukemia Research · doi:10.1016/s0145-2126(02)00074-7 · Cited by 3 · see citing works
Yılmaz, H., Aytaç, S., Kuşkonmaz, B., Çetinkaya, D., Ünal, Ş., & Gümrük, F. (2024) · Turkish Journal of Hematology · doi:10.4274/tjh.galenos.2024.2024.0066 · Cited by 1 · see citing works
Self-citationCerebrospinal fluid oxidant/antioksidant status in children with acute lymphoblastic leukemia
Ayçiçek, A., Koç, A., Adar, B., & Solmaz, A. (2014) · DergiPark (Istanbul University)
- Authors
- Yetgin, S., Gürgey, A., Murat Tuncer, A., Çetin, M., Özbek, N., Şayli, T., Güler, E., Kara, A., Olcay, L., Duru, F., Gümrük, F., Atahan, L., & Tunçbilek, E.
- Affiliations
- Hacettepe University (TR)
- Hacettepe University Hospital (TR)
- Corresponding author
- Yetgin, Sevgi
- Venue
- Leukemia Research
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 22
- Issue
- 6
- Pages
- 485-493
- ISSN
- 0145-2126 (ISSN-L)
- OpenAlex
- W2053130412
- Cited by
- 26
- References
- 35
- Citations by year
- 2024: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Leukemia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Keywords
- high-dose methylprednisolone, prednisolone, acute lymphoblastic leukemia, pediatric leukemia, induction chemotherapy, event-free survival, relapse, high-risk patients, glucocorticoids
- MeSH terms
- Adolescent, Age Factors, Antineoplastic Agents, Child, Child, Preschool, Dose-Response Relationship, Drug, Female, Humans, Infant, Infections, Leukocyte Count, Male, Methylprednisolone, Neutropenia, Prednisolone, Recurrence, Remission Induction, Risk Factors, Time Factors, Leukemia, Myeloid, Acute, Survival Rate, Disease-Free Survival, Precursor Cell Lymphoblastic Leukemia-Lymphoma
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
