Cited by 114Invertebrate Immune Response MechanismsImmune Response and InflammationAquaculture disease management and microbiota

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Role of lectins in the innate immunity of horseshoe crab

Kawabata, Shun-ichiro, Iwanaga, Sadaaki·1999·Developmental & Comparative Immunology

DOI 10.1016/s0145-305x(99)00019-1

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Abstract

We have purified five types of lectins, named tachylectins, from circulating hemocytes and hemolymph plasma of the Japanese horseshoe crab, Tachypleus tridentatus. Tachylectin-1 interacts with Gram-negative bacteria probably through 2-keto-3-deoxyoctonate, one of the constituents of lipopolysaccharides (LPS). Tachylectin-1 also binds to polysaccharides such as agarose and dextran with broad specificity. Tachylectin-2 binds to D-GlcNAc or D-GalNAc and recognizes staphylococcal lipoteichoic acids and LPS from several Gram-negative bacteria. In contrast, tachylectins-3 and -4 specifically bind to S-type LPS from several Gram-negative bacteria through a certain sugar moiety on the O-specific polysaccharides (O-antigens). Tachylectin-5 identified in hemolymph plasma has the strongest bacterial agglutinating activity in the five types of tachylectins, and exhibits broad specificity against acetyl group-containing substances. Thus, the innate immune system of horseshoe crab may recognize invading pathogens through a combinatorial method using lectins with different specificities against carbohydrates exposed on pathogens. An encounter of these lectins derived from hemocytes and hemolymph plasma at injured sites, in response to the stimulation of LPS, suggests that they serve synergistically to accomplish an effective host defense against invading microbes and foreign substances.

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Authors: Kawabata, S.-I., & Iwanaga, S.
Affiliations: Kyushu University (JP)
Corresponding author: Kawabata, Shun-ichiro
Venue: Developmental & Comparative Immunology
Publisher: Elsevier BV
Published: 1999-06
Volume: 23
Issue: 4-5
Pages: 391-400
ISSN: 0145-305X (ISSN-L)
DOI: 10.1016/s0145-305x(99)00019-1
OpenAlex: W2025265837
Cited by: 114
References: 27
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 1 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 4
FWCI: 1.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Developmental & Comparative Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Core Research for Evolutional Science and Technology
Naito Foundation
Japan Science and Technology Corporation
Topics: Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
Keywords: lectins, horseshoe crab, Tachypleus tridentatus, innate immunity, hemocytes, lipopolysaccharide recognition, Gram-negative bacteria, bacterial agglutination, O-antigen, lipoteichoic acid, carbohydrate recognition, host defense
MeSH terms: Animals, Gram-Negative Bacteria, Hemocytes, Horseshoe Crabs, Immunity, Innate, Lipopolysaccharides, Teichoic Acids, Sequence Alignment, O Antigens, Lectins

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