Cited by 350Medication Adherence and ComplianceDiabetes Management and EducationDiabetes Treatment and Management

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Predictors of medication adherence and associated health care costs in an older population with type 2 diabetes mellitus: A longitudinal cohort study

Balkrishnan, Rajesh, Rajagopalan, Rukmini, Camacho, Fabian T., Huston, Sally A., Murray, Frederick T., Anderson, Roger T.·2003·Clinical Therapeutics

DOI 10.1016/s0149-2918(03)80347-8

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Abstract

Background The cost of treating diabetes mellitus and its complications is high (91.8 billion dollars in the United States in 2002). It is important to understand predictors of adherence to therapy with different antidiabetic medications and to determine the relationships between adherence and health care service utilization in older adults (aged >or=65 years) with type 2 diabetes mellitus.Objective The aim of this study was to examine the relationship between self-reported health status data, subsequent antidiabetic medication adherence, and health care service utilization in older adults with type 2 diabetes mellitus in a managed care setting.Methods This was a longitudinal cohort study of older adults in the south-eastern United States with type 2 diabetes mellitus who completed a health status assessment, used antidiabetic medications, and were enrolled in a health maintenance organization (HMO) continuously for 1 to 5 years. The baseline assessment included questions related to demographics, health care service utilization in the year before enrollment, lifestyle, and quality of life. Demographic, clinical, and utilization-related economic variables were also retrieved from the administrative claims data of the patients' HMO. Prescription refill patterns were used to measure adherence. Associations were examined with a sequential, mixed-model, regression approach. Model appropriateness was tested via sensitivity analyses with logged and unlogged dependent variables.Results A total of 775 patients were included. Increased comorbidity severity and an emergency room visit during the year prior to enrollment in a Medicare HMO were independently associated with decreased antidiabetic medication possession ratios (MPRs) after enrollment. After controlling for type of medication therapy and other variables, increased antidiabetic MPR remained the strongest predictor of decreased total annual health care costs (8.6% to 28.9% decrease in annual costs with every 10% increase in MPR; P < 0.001). Adherence to anti-diabetic medications was a greater driver of cost reduction than other concurrent medications (eg, statins) in this population.Conclusions This study found strong associations between decreased anti-diabetic medication adherence and increased health care service utilization in older adults with type 2 diabetes mellitus in a managed care setting. Health status assessments completed at time of enrollment had the potential to identify enrollees with higher risk for both nonadherent behaviors and poor health-related outcomes.

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A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Specification Tests in Econometrics
Hausman, J. A. (1978) · Econometrica · doi:10.2307/1913827 · Cited by 18,820
A 12-Item Short-Form Health Survey: Construction of Scales and Preliminary Tests of Reliability and Validity
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452
Revisiting the Behavioral Model and Access to Medical Care: Does it Matter?
Andersen, R. M. (1995) · Journal of Health and Social Behavior · doi:10.2307/2137284 · Cited by 9,831
The Lagrange Multiplier Test and its Applications to Model Specification in Econometrics
Breusch, T., & Pagan, A. R. (1980) · The Review of Economic Studies · doi:10.2307/2297111 · Cited by 9,036
Economic Costs of Diabetes in the U.S. in 2002
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.3.917 · Cited by 4,147
Pharmacotherapy: A Pathophysiologic Approach
(1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-5-447_3 · Cited by 2,402
Why People Use Health Services
Rosenstock, I. M. (2005) · Milbank Quarterly · doi:10.1111/j.1468-0009.2005.00425.x · Cited by 2,329

Show all 32 references

Research works printed but not linked: 1

Kennedy, 1981, Estimation with correctly interpreted dummy variables in semilogarithmic equations, Am Econ Rev., 71, 801

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Doró, P., Benkő, R., Kosik, E., Matúz, M., Tóth, K., & Soós, G. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0031-9 · Cited by 37
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Pool, A. C., Kraschnewski, J. L., Poger, J. M., Smyth, J. M., Stuckey, H. L., Craig, T., Lehman, E. B., Yang, C., & Sciamanna, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170447 · Cited by 37
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Vadhariya, A., Fleming, M. L., Johnson, M. L., Essien, E. J., Serna, O., Esse, T. W., Choi, J., Boklage, S., & Abughosh, S. (2019) · Europe PMC (PubMed Central) · Cited by 33
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Rout, S. K., Swain, S., Samal, S., & Sahu, K. S. (2018) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_24_18 · Cited by 34
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Nietert, P. J., Tilley, B. C., Zhao, W., Edwards, P. F., Wessell, A. M., Mauldin, P. D., & Polk, P. P. (2008) · Medical Care · doi:10.1097/mlr.0b013e3181808c17 · Cited by 32
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Race and medication adherence and glycemic control: findings from an operational health information exchange.
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Effect of patient medication cost share on adherence and glycemic control.
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Self-citation
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Hussain, N., Said, A. S. A., & Khan, Z. (2019) · International Quarterly of Community Health Education · doi:10.1177/0272684x19896724 · Cited by 23
Self-Care and Health Outcomes of Diabetes Mellitus
Song, M., Ratcliffe, S. J., Tkacs, N. C., & Riegel, B. J. (2011) · Clinical Nursing Research · doi:10.1177/1054773811422604 · Cited by 27
Self-reported treatment adherence in inflammatory bowel disease in Indian patients
Bhatt, J., Patil, S., Joshi, A. G., Abraham, P., & Desai, D. (2009) · Indian Journal of Gastroenterology · doi:10.1007/s12664-009-0050-z · Cited by 28
Effect of insulin pen devices on the management of diabetes mellitus
Meece, J. D. (2008) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp070524 · Cited by 27
Demographic, Socioeconomic, and Psychological Factors Related to Medication Non-adherence Among Emergency Department Patients
Davis, D. P., Jandrisevits, M. D., Iles, S., Weber, T. R., & Gallo, L. C. (2009) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2009.04.008 · Cited by 25
Increasing Medicare Part D Enrollment In Medication Therapy Management Could Improve Health And Lower Costs
Stuart, B., Loh, F. E., Roberto, P. N., & Miller, L. M. (2013) · Health Affairs · doi:10.1377/hlthaff.2012.0848 · Cited by 25
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Self-citation
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Impact of diabetes control on mortality by race in a national cohort of veterans
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Stuart, B., Yin, X., Davidoff, A. J., Simoni, J. M., Zuckerman, I. H., Shoemaker, J. S., & Doshi, J. A. (2012) · Medical Care · doi:10.1097/mlr.0b013e31826c85f9 · Cited by 22
Patient and parent preferences for immunoglobulin treatments: a conjoint analysis
Mohamed, A. F., Kilambi, V., Luo, M. P., Iyer, R. G., & Li-McLeod, J. M. (2012) · Journal of Medical Economics · doi:10.3111/13696998.2012.716804 · Cited by 25
Using the extended self-regulatory model to characterise diabetes medication adherence: a cross-sectional study
Shiyanbola, O. O., Unni, E., Huang, Y., & Lanier, C. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022803 · Cited by 23
Poor Adherence to Anti-inflammatory Medication in Asthma
Elliott, R. A. (2006) · Disease Management & Health Outcomes · doi:10.2165/00115677-200614040-00005 · Cited by 22
A Multichannel Medication Adherence Intervention Influences Patient and Prescriber Behavior
Leslie, R. S., Gilmer, T., Natarajan, L., & Hovell, M. F. (2016) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2016.22.5.526 · Cited by 22
Physicians' and other professionals' expectations and prognoses for mentally retarded individuals.
Wolraich, M. L., & Siperstein, G. N. (1986) · PubMed · Cited by 22
Cost Sharing and Decreased Branded Oral Anti-Diabetic Medication Adherence Among Elderly Part D Medicare Beneficiaries
Sacks, N. C., Burgess, J. F., Cabral, H., Pizer, S. D., & McDonnell, M. E. (2013) · Journal of General Internal Medicine · doi:10.1007/s11606-013-2342-3 · Cited by 21
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Oral Antidiabetes Medication Adherence and Health Care Utilization Among Medicaid-Enrolled Type 2 Diabetic Patients Beginning Monotherapy
Shenolikar, R. A., & Balkrishnan, R. (2008) · Diabetes Care · doi:10.2337/dc07-1442 · Cited by 21
Self-citation
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Medication adherence for 90-day quantities of medication dispensed through retail and mail order pharmacies.
Khandelwal, N., Duncan, I. G., Rubinstein, E., Ahmed, T., Pegus, C., Murphy, P., & Kudrak, K. E. (2011) · PubMed · Cited by 20
Comparisons of Rosiglitazone Versus Pioglitazone Monotherapy Introduction and Associated Health Care Utilization in Medicaid-Enrolled Patients with Type 2 Diabetes Mellitus
Balkrishnan, R., Arondekar, B. V., CAMACHO, F. T., Shenolikar, R. A., Horblyuk, R. V., & Anderson, R. T. (2007) · Clinical Therapeutics · doi:10.1016/j.clinthera.2007.06.019 · Cited by 20
Self-citation
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Zarowitz, B. J. M., & Conner, C. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.pt2.55s · Cited by 20
Real-life comparison of DPP4-inhibitors with conventional oral antidiabetics as add-on therapy to metformin in elderly patients with type 2 diabetes: The HYPOCRAS study
Penfornis, A., Bourdel‐Marchasson, I., Quéré, S., & Dejager, S. (2012) · Diabetes & Metabolism · doi:10.1016/j.diabet.2012.08.003 · Cited by 19
Pharmaceutical Cost-Saving Strategies and their Association with Medication Adherence in a Medicare Supplement Population
Musich, S. A., Cheng, Y., Wang, S. S., Hommer, C. E., Hawkins, K., & Yeh, C. S. (2015) · Journal of General Internal Medicine · doi:10.1007/s11606-015-3196-7 · Cited by 19
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de Araújo, M. F. M., Gonçalves, T. D. C., Damasceno, M. M. C., & Caetano, J. Á. (2010) · Escola Anna Nery · doi:10.1590/s1414-81452010000200021 · Cited by 19
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Sharma, K. P., & Taylor, T. N. (2012) · Medical Care · doi:10.1097/mlr.0b013e318249d800 · Cited by 19
Adherence to Oral Antihyperglycemic Agents Among Older Adults With Mental Disorders and Its Effect on Health Care Costs, Quebec, Canada, 2005-2008.
Gentil, L., Vasiliadis, H., Préville, M., & Berbiche, D. (2015) · Europe PMC (PubMed Central) · doi:10.5888/pcd12.150412 · Cited by 19
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Kuo, W., Shyu, Y. L., Wang, J., Chen, C.-F., Wu, C., & Chen, M. (2019) · Nursing Research · doi:10.1097/nnr.0000000000000371 · Cited by 19
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Yerrapragada, G., Siadimas, A., Babaeian, A., Sharma, V., & O’Neill, T. J. (2021) · JCO Clinical Cancer Informatics · doi:10.1200/cci.20.00102 · Cited by 21
Interventions for improving medication-taking ability and adherence in older adults prescribed multiple medications
Cross, A. J., Elliott, R. A., & George, J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012419 · Cited by 21
Antimigraine medication use and associated health care costs in employed patients
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Meyer, J. W., Schultz, J. S., O’Donnell, J. C., Patel, P., & Sasané, R. (2005) · Value in Health · doi:10.1111/j.1524-4733.2005.00052.x · Cited by 19
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Evolving Metformin Treatment Strategies in Type-2 Diabetes
Chacra, A. R. (2012) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318235f1bb · Cited by 20
Medication Adherence to Oral Hypoglycemic Drugs among Individuals with Type 2 Diabetes Mellitus – A Community Study
Aravindakshan, R., Abraham, S., & Aiyappan, R. (2021) · Indian Journal of Community Medicine · doi:10.4103/ijcm.ijcm_985_20 · Cited by 15
Towards Personalizing Treatment for Depression
Wittink, M. N., Morales, K. H., Cary, M. S., Gallo, J. J., & Bartels, S. J. (2013) · Patient · doi:10.1007/s40271-013-0003-6 · Cited by 18
Does intervention by an allied health professional discussing adherence to medicines improve this adherence in Type 2 diabetes?
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Authors: Balkrishnan, R., Rajagopalan, R., Camacho, F. T., Huston, S. A., Murray, F. T., & Anderson, R. T.
Affiliations: Wake Forest University Health Sciences (US)
Takeda (United States) (US)
University of Michigan (US)
Corresponding author: Balkrishnan, Rajesh
ORCID: Balkrishnan, Rajesh
Camacho, Fabian T.
Huston, Sally A.
Anderson, Roger T.
Venue: Clinical Therapeutics
Publisher: Elsevier BV
Published: 2003-11
Volume: 25
Issue: 11
Pages: 2958-2971
ISSN: 0149-2918 (ISSN-L)
DOI: 10.1016/s0149-2918(03)80347-8
OpenAlex: W2144002425
Cited by: 350
References: 32
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 16 · 2018: 22 · 2017: 16 · 2016: 22 · 2015: 19 · 2014: 20 · 2013: 24 · 2012: 27
FWCI: 11.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: Takeda Pharmaceuticals North America
Claude Pepper Older Americans Independence Center, Wake Forest School of Medicine
Topics: Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: medication adherence, type 2 diabetes, older adults, health care costs, health care utilization, antidiabetic drugs, medication possession ratio, comorbidities, emergency department visits, health assessment, managed care, Medicare HMOs, prescription refills
MeSH terms: Aged, Diabetes Mellitus, Type 2, Female, Health Maintenance Organizations, Health Services, Health Status, Humans, Hypoglycemic Agents, Longitudinal Studies, Male, Patient Compliance, Health Care Costs

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Predictors of medication adherence and associated health care costs in an older population with type 2 diabetes mellitus: A longitudinal cohort study

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