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Cited by 686Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityReproductive Biology and Fertility

The DOI matches its Crossref record; 528 of the 538 references it cites were found in a registry or an index.

Metabolic fuels and reproduction in female mammals

Wade, George N., Schneider, Jill E.·1992·Neuroscience & Biobehavioral Reviews
DOI 10.1016/s0149-7634(05)80183-6
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Abstract

A complete reproductive cycle of ovulation, conception, pregnancy, and lactation is one of the most energetically expensive activities that a female mammal can undertake. A reproductive attempt at a time when calories are not sufficiently available can result in a reduced return on the maternal energetic investment or even in the death of the mother and her offspring. Numerous physiological and behavioral mechanisms link reproduction and energy metabolism. Reproductive attempts may be interrupted or deferred when food is scarce or when other physiological processes, such as thermoregulation or fattening, make extraordinary energetic demands. Food deprivation suppresses both ovulation and estrous behavior. The neural mechanisms controlling pulsatile release of gonadotropin-releasing hormone (GnRH) and, consequently, luteinizing hormone secretion and ovarian function appear to respond to minute-to-minute changes in the availability of metabolic fuels. It is not clear whether GnRH-secreting neurons are able to detect the availability of metabolic fuels directly or whether this information is relayed from detectors elsewhere in the brain. Although pregnancy is less affected by fuel availability, both lactational performance and maternal behaviors are highly responsive to the energy supply. When a reproductive attempt is made, changes in hormone secretion have dramatic effects on the partitioning and utilization of metabolic fuels. During ovulatory cycles and pregnancy, the ovaria…

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Research works printed but not linked: 22

  1. Berriman, 1991, Food deprivation decreases c-fos expression in gonadotropin-releasing hormone (GnRH) neurons in Syrian hamsters, Soc. Neurosci. Abstr., 17, 1363
  2. Bronson, 1988, Effect of food manipulation on the gonadotropin releasing hormone-luteinizing hormone-estradiol axis of the young female rat, Am. J. Physiol., 254, R616
  3. Bucholtz, 1990, Is growth hormone an important cue timing puberty in the female lamb?, Biol. Reprod., 42, 46
  4. Calingasan, 1990, Effects of lesioning the amygdala, parabrachial nucleus, and the hypothalamic paraventricular nucleus on lipoprivic and glucoprivic feeding, Soc. Neurosci. Abstr., 16, 1251
  5. Cumming, 1987, The reproductive effects of exercise and training, Curr. Prob. Obstet. Gynecol. Fertil., 10, 225
  6. Dickerman, 1991, Food deprivation suppresses steroid-induced estrous behavior in ovariectomized Syrian hamsters, Soc. Neurosci. Abstr., 17, 500
  7. Dickerman, 1990, Decreased availability of metabolic fuels attenuates the preovulatory LH surge in Syrian hamsters, Soc. Neurosci. Abstr., 16, 399
  8. Gray, 1981, In vivo cell nuclear binding of 17β-[3H]estradiol in rat adipose tissues, Am. J. Physiol., 240, E43
  9. Gray, 1983, Uterine and adipose tissue lipoprotein lipase activity in hormone-treated and pregnant rats, Am. J. Physiol., 245, E132
  10. Gray, 1980, Cytoplasmic estrogen, but not progestin, receptors in male rat adipose tissues, Am. J. Physiol., 239, E237
  11. Hileman, 1991, Effects of metabolic fuel restriction on patterns of LH and GH in ovariectomized lambs, Biol. Reprod., 44, 138
  12. Kassil, 1970, Regulation of selection and consumption of food and metabolism, Prog. Physiol. Sci., 1, 387
  13. Kaur, 1982, Influence of level of nutrition and season on the oestrous cycle rhythm and on fertility in buffaloes, Trop. Agric., 59, 274
  14. Kinder, 1987, Endocrine regulation of puberty in cows and ewes, J. Reprod. Fert. Suppl., 34, 167
  15. Lazzarini, 1988, Role of the sympathetic nerves in the action of estradiol on white adipose tissue, Soc. Neurosci. Abstr., 14, 215
  16. LeMagnen, 1971, Advances in studies on the physiological control and regulation of food intake, vol. 4, 203
  17. Li, 1991, Effects of diabetes mellitus on estrous cyclicity and copulatory behavior in female Syrian hamsters, Soc. Neurosci. Abstr., 17, 499
  18. McClure, 1962, Infertility in female rodents caused by temporary inanition at or about the time of implantation, J. Reprod. Fert., 4, 241
  19. McShane, 1990, Effects of free fatty acids on luteinizing hormone and growth hormone secretion in ovariectomized lambs, Endocrinology, 126, 1934, 10.1210/endo-126-4-1934 · DOI
  20. Richter, 1943, Total self-regulatory functions in animals and human beings, The Harvey Lectures, 38, 63
  21. Sadlier, 1969, The role of nutrition in the reproduction of wild mammals, J. Reprod. Fert., 39
  22. Schneider, 1991, Signals generated in CNS glucose metabolism affect estrous cycles in Syrian hamsters, Soc. Neurosci. Abstr., 17, 499

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Metadata

Authors
Wade, G. N., & Schneider, J. E.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Wade, George N.
ORCID
Schneider, Jill E.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1992-06
Volume
16
Issue
2
Pages
235-272
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/s0149-7634(05)80183-6
OpenAlex
W2004945873
Cited by
686
References
538
Citations by year
2026: 8 · 2025: 17 · 2024: 13 · 2023: 18 · 2022: 21 · 2021: 13 · 2020: 18 · 2019: 20 · 2018: 17 · 2017: 28 · 2016: 17 · 2015: 17 · 2014: 25 · 2013: 25 · 2012: 26
FWCI
11.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk032976-09)
  • National Institute of Mental Health (MH 00321)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 32976)
  • National Institute of Neurological Disorders and Stroke (NS 10873)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
energy metabolism, reproduction, female mammals, food deprivation, ovulation, estrous cycle, pregnancy, lactation, gonadotropin-releasing hormone, luteinizing hormone, estradiol, progesterone, prolactin, growth hormone, dietary intake, thermoregulation, maternal behavior
MeSH terms
Animals, Female, Humans, Mammals, Metabolism, Reproduction

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