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Biological basis of the behavior of sick animals

Hart, Benjamin L.·1988·Neuroscience & Biobehavioral Reviews
DOI 10.1016/s0149-7634(88)80004-6
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Abstract

The most commonly recognized behavioral patterns of animals and people at the onset of febrile infectious diseases are lethargy, depression, anorexia, and reduction in grooming. Findings from recent lines of research are reviewed to formulate the perspective that the behavior of sick animals and people is not a maladaptive response or the effect of debilitation, but rather an organized, evolved behavioral strategy to facilitate the role of fever in combating viral and bacterial infections. The sick individual is viewed as being at a life or death juncture and its behavior is an all-out effort to overcome the disease.

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Research works printed but not linked: 127

  1. Aarden, 1987, Production of hybridoma growth factor by human monocytes, Eur. J. Immunol., 17, 1411, 10.1002/eji.1830171004 · DOI
  2. Adels, 1986, Thermal control of mother-young contact in Norway rats: Factors mediating chronic elevation of maternal temperature, Physiol. Behav., 36, 183, 10.1016/0031-9384(86)90094-6 · DOI
  3. Atkins, 1984, Fever: The old and the new, J. Infect. Dis., 149, 339, 10.1093/infdis/149.3.339 · DOI
  4. Atkins, 1972, Fever, N. Engl. J. Med., 286, 27, 10.1056/NEJM197201062860109 · DOI
  5. Ballantyne, 1983, Rapid drop in serum iron concentration following cholecystectomy, Am. Surg., 49, 146
  6. Banet, 1979, Fever and survival in the rat, Pflugers Arch., 381, 35, 10.1007/BF00582329 · DOI
  7. Banet, 1986, Fever in mammals: Is it beneficial?, Yale J. Biol. Med., 59, 117
  8. Banet, 1981, The effect of whole body heat exposure and of cooling the hypothalamus on antibody titre in the rat, Pflugers Arch., 391, 25, 10.1007/BF00580689 · DOI
  9. Baracos, 1983, Stimulation of muscle protein degradation by leukocytic pyrogen (interleukin-1), N. Engl. J. Med., 308, 553, 10.1056/NEJM198303103081002 · DOI
  10. Barr, 1922, Clinical calorimetry XXXII. Temperature regulation after the intravenous injection of protease and typhoid vaccine, Arch. Intern. Med., 29, 608, 10.1001/archinte.1922.00110050055004 · DOI
  11. Beisel, 1975, Metabolic response to infection, Annu. Rev. Med., 26, 9, 10.1146/annurev.me.26.020175.000301 · DOI
  12. Beisel, 1983, Mediators of fever and muscle proteolysis, N. Engl. J. Med., 308, 586, 10.1056/NEJM198303103081009 · DOI
  13. Bell, 1962, Effects of limb disability on lousiness in mice. I. Preliminary studies, Exp. Parasitol., 12, 176, 10.1016/0014-4894(62)90055-3 · DOI
  14. Bennett, 1969, The effect of grooming on experimental cattle tick infestation, Exp. Parasitol., 26, 323, 10.1016/0014-4894(69)90125-8 · DOI
  15. Bennett, 1953, Studies on the pathogenesis of fever. I. The effect of the injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits, J. Exp. Med., 98, 477, 10.1084/jem.98.5.477 · DOI
  16. Bennett, 1960, Fever as a mechanism of resistance, Bacterial Rev., 24, 18
  17. Bernheim, 1976, Fever: Effect of drug-induced antipyresis on survival, Science, 193, 237, 10.1126/science.935867 · DOI
  18. Beutler, 1986, Cachectin and tumor necrosis as two sides of the same biological coin, Nature, 32, 584, 10.1038/320584a0 · DOI
  19. Bezkorovainy, 1981, Antimicrobial properties of iron-binding proteins, Adv. Exp. Med. Biol., 135, 139
  20. Blatteis, 1986, Fever: Is it beneficial?, Yale J. Biol. Med., 59, 107
  21. Bolles, 1960, Grooming behavior in the rat, J. Comp. Physiol. Psychol., 53, 306, 10.1037/h0045421 · DOI
  22. Breder, 1988, Interleukin-1 immunoreactive innervation of the human hypothalamus, Science, 240, 321, 10.1126/science.3258444 · DOI
  23. Byrant, 1971, Factors affecting mortality of gram-negative rod bacteria, Arch. Intern. Med., 127, 120, 10.1001/archinte.127.1.120 · DOI
  24. Bullen, 1981, The significance of iron on infection, Rev. Infect. Dis., 3, 1127, 10.1093/clinids/3.6.1127 · DOI · Paper page
  25. Carmichael, 1969, Effect of temperature on the growth of canine herpesvirus in dog kidney cell and macrophage cultures, J. Infect. Dis., 120, 664, 10.1093/infdis/120.6.664 · DOI
  26. Carmichael, 1969, Temperature as a factor in resistance of young puppies to canine herpesvirus, J. Infect. Dis., 120, 669, 10.1093/infdis/120.6.669 · DOI
  27. Caverzasio, 1987, Interleukin-1 decreases renal sodium reabsorption: possible mechanism of endotoxin-induced natriuresis, Am. J. Physiol., 252, F943
  28. Coceani, 1986, Prostaglandin E2 and fever: a continuing debate, Yale J. Biol. Med., 59, 169
  29. Corsett, 1922, Remarks on “hog flu”, J. Am. Vet. Med. Assoc., 62, 162
  30. Covert, 1977, Survival value of fever in fish, Nature, 267, 43, 10.1038/267043a0 · DOI
  31. Davis, 1979, Fever. J. Am. Vet. Med. Assoc., 175, 1210
  32. Depelchin, 1985, Clinical and experimental modifications of plasma iron and zinc concentrations in cattle, Vet. Rec., 116, 519, 10.1136/vr.116.19.519 · DOI
  33. Dinarello, 1984, Interleukin-1, Rev. Infect. Dis., 6, 51, 10.1093/clinids/6.1.51 · DOI
  34. Dinarello, 1985, An update on human interleukin-1: From molecular biology to clinical relevance, J. Clin. Immunol., 5, 287, 10.1007/BF00918247 · DOI
  35. Dinarello, 1986, Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin), Year. Immunol., 2, 68
  36. Dinarello, 1988, Biology in interleukin 1, FASEB, 2, 108, 10.1096/fasebj.2.2.3277884 · DOI
  37. Disilestro, 1985, Induction of rat metallothionen by interleukin-1, J. Leukocyte Biol., 37, 697
  38. Duff, 1982, Fever and immunoregulation: Hyperthermia, interleukin 1 and 2 and T-cell proliferation, Yale J. Biol. Med., 55, 437
  39. Duff, 1983, The pyrogenic and mitogenic actions of interleukin-1 are related, Nature, 304, 449, 10.1038/304449a0 · DOI
  40. Dupont, 1969, Infections due to gram-negative organisms: An analysis of 866 patients with bacteremia at the University of Minnesota Medical Center, 1958–1966, Medicine, 48, 307, 10.1097/00005792-196907000-00003 · DOI
  41. Elin, 1974, The role of iron in nonspecific resistance to infection induced by endotoxin, J. Immunol., 112, 737, 10.4049/jimmunol.112.2.737 · DOI
  42. Ewald, 1980, Evolutionary biology and the treatment of signs and symptoms of infectious disease, J. Theor. Biol., 86, 169, 10.1016/0022-5193(80)90073-9 · DOI
  43. 1986, vol. 1
  44. Finkelstein, 1983, Pneumococcal bacteremia in adults: Age-dependent differences in presentation and outcome, J. Am. Geriatr. Soc., 31, 19, 10.1111/j.1532-5415.1983.tb06283.x · DOI
  45. Flynn, 1984, Stimulation of interleukin-1 production from placental monocytes, Lymphokine Res., 3, 1
  46. Gleckman, 1982, Afebrile bacteremia. A phenomenon in geriatric patients, J. Am. Med. Assoc., 248, 1478, 10.1001/jama.248.12.1478 · DOI
  47. Grieger, 1978, Fever and survival: The role of serum iron, J. Physiol., 279, 187, 10.1113/jphysiol.1978.sp012339 · DOI
  48. Harlow, 1974, Induced depression in monkeys, Behav. Biol., 12, 273, 10.1016/S0091-6773(74)91475-8 · DOI
  49. Hart, 1985, Animal behavior and the fever response, J. Am. Vet. Med. Assoc., 187, 998
  50. Hoffman-Goetz, 1985, Fever and survival in aged mice after endotoxin challenge, J. Gerontol., 40, 15, 10.1093/geronj/40.1.15 · DOI
  51. Hoffman, 1979, Protein deprivation: Its effects on fever and plasma iron during bacterial infection in rabbits, J. Physiol., 295, 419, 10.1113/jphysiol.1979.sp012977 · DOI
  52. Holbein, 1980, Iron-controlled infection with Neisseria meningitidis in mice, Infect. Immun., 29, 886, 10.1128/iai.29.3.886-891.1980 · DOI
  53. Holbein, 1981, Enhancement of Neisseria meningitidis infection in mice by addition of iron bound to transferrin, Infect. Immun., 34, 120, 10.1128/IAI.34.1.120-125.1981 · DOI
  54. Husseini, 1982, Elevation of nasal viral levels by suppression of fever in ferrets infected with influenza viruses of differing virulence, J. Infect. Dis., 145, 520, 10.1093/infdis/145.4.520 · DOI
  55. Ismail, 1986, Effect elevated temperatures and low levels of trace metals on the growth and phenotypic development of Candida albicans, Mycopathologicia, 94, 45, 10.1007/BF00437261 · DOI
  56. Janis, 1983, The effects of lactation and ambient temperature on the body temperature of female Norway rats, Physiol. Behav., 30, 959, 10.1016/0031-9384(83)90261-5 · DOI
  57. Janpel, 1983, Fever and immunoregulation. III. Hyperthermia augments the primary in vitro humoral immune response, J. Exp. Med., 157, 1229, 10.1084/jem.157.4.1229 · DOI
  58. Jeddi, 1970, Confort du contact et thermorégulation comportementale, Physiol. Behav., 5, 1487, 10.1016/0031-9384(70)90140-X · DOI
  59. Jeddi, 1971, Thermoregulatory efficiency of neonatal rabbit search for fur comfort contact, Int. J. Biometeorol., 15, 337, 10.1007/BF01803923 · DOI
  60. Kaufman, 1967, The reaction to separation in infant monkeys: Anaclitic depression and conservation-withdrawal, Psychosom. Med., 29, 648, 10.1097/00006842-196711000-00010 · DOI
  61. Kirby, 1982, Urinary excretion of zinc and iron following injection of bacteria in the unanesthetized rabbit, Min. Elect. Metab., 7, 250
  62. Kluger, 1978, The evolution and adaptive value of fever, Am. Scient., 66, 38
  63. Kluger, 1979, Fever ectotherms: Evolutionary implications, Am. Zool., 19, 295, 10.1093/icb/19.1.295 · DOI
  64. Kluger, 1975, Fever and survival, Science, 188, 166, 10.1126/science.1114347 · DOI
  65. Kluger, 1979, Fever and reduced iron: Their interaction as a host defense response to bacterial infection, Science, 203, 374, 10.1126/science.760197 · DOI
  66. Kluger, 1978, Fever and survival in rabbits infected with Pasteurella multocida, J. Physiol., 282, 243, 10.1113/jphysiol.1978.sp012460 · DOI
  67. Krakauer, 1986, Human interleukin-1, CRC Crit. Rev. Immunol., 6, 213
  68. Krueger, 1986, Enhancement of slow-wave sleep by endotoxin and lipid A, Am. J. Physiol., 251, R591
  69. Krueger, 1984, Sleep-promoting effects of endogenous pyrogen (interleukin-1), Am. J. Physiol., 246, R994
  70. Le, 1987, Tumor necrosis factor and interleukin-1: Cytokines with multiple overlapping biological activities, Lab Invest., 56, 234
  71. Leon, 1978, Thermal control of mother-young contract in rats, Physiol. Behav., 21, 793, 10.1016/0031-9384(78)90021-5 · DOI
  72. Letendre, 1984, Mechanism of impaired iron release by the reticuloendothelial system during the hypoferremic phase of experimental Neisseria meningitidis infection in mice, Infect. Immun., 44, 320, 10.1128/IAI.44.2.320-325.1984 · DOI
  73. McCarthy, 1984, The role of fever in appetite suppression after endotoxin administration, Am. J. Clin. Nutr., 40, 310, 10.1093/ajcn/40.2.310 · DOI
  74. McCarthy, 1985, Suppression of food intake during infection: Is interleukin-1 involved?, Am. J. Clin. Nutr., 42, 1179, 10.1093/ajcn/42.6.1179 · DOI
  75. McCarthy, 1986, Effect of centrally administered interleukin-1 and endotoxin on food intake of fasted rats, Physiol. Behav., 36, 745, 10.1016/0031-9384(86)90363-X · DOI
  76. MacKowiak, 1981, Direct effects of hyperthermia on pathogenic microorganisms: Teleologic implications with regard to fever, Rev. Infect. Dis., 3, 508, 10.1093/clinids/3.3.508 · DOI
  77. 1982, vol. 1
  78. Manzella, 1979, Human macrophage and lymphocyte responses to mitogen stimulation after exposure to influenza virus, ascorbic acid, and hyperthermia, J. Immunol., 123, 1044, 10.4049/jimmunol.123.5.1940 · DOI
  79. Marx, 1988, Orphan interferon finds a new home, Science., 239, 25, 10.1126/science.3276001 · DOI
  80. Maurer, 1963, African horse sickness—with emphasis on pathology, Am. J. Vet. Res., 24, 235
  81. Mineka, 1978, Social separation in monkeys, Psychol. Bull., 85, 1376, 10.1037/0033-2909.85.6.1376 · DOI
  82. Mitchell, 1986, Is prostagladin E the neural mediator of the febrile response? The case against a proven obligatory role, Yale J. Biol. Med., 59, 156
  83. Mrosovsky, 1976, Lipid programmes and life strategies in hibernators, Am. Zool., 16, 685, 10.1093/icb/16.4.685 · DOI
  84. Mrosovsky, 1980, Animal anorexias, Science, 207, 837, 10.1126/science.6928327 · DOI
  85. Murray, 1961, The ecology of the louse Polyplax serrata (Burm.) on the mouse Mus musculus L, Aust. J. Zool., 9, 1, 10.1071/ZO9610001 · DOI
  86. Murray, 1987, Effects of host grooming on louse populations, Parasitol. Today, 3, 276, 10.1016/0169-4758(87)90105-0 · DOI
  87. Murray, 1979, Anorexia of infection as a mechanism of host defense, Am. J. Clin. Nutr., 32, 593, 10.1093/ajcn/32.3.593 · DOI
  88. Murray, 1978, The adverse effect of iron repletion on the courses of certain infections, Br. Med. J., 2, 1113, 10.1136/bmj.2.6145.1113 · DOI · Paper page
  89. Muschenheim, 1943, Hypothermia in experimental infections. III. The effect of hypothermia on resistance to experimental pneumococcus infection, J. Infect. Dis., 72, 187, 10.1093/infdis/72.3.187 · DOI
  90. Nijsten, 1987, Serum levels of interleukin-6 and acute phase responses, Lancet, ii, 921, 10.1016/S0140-6736(87)91413-9 · DOI
  91. Norman, 1985, Fever and aging, J. Am. Geriatr. Soc., 33, 859, 10.1111/j.1532-5415.1985.tb05441.x · DOI
  92. Otterness, 1988, The effects of continuous administration of murine interleukin-1α in the rat, Physiol Behav., 43, 10.1016/0031-9384(88)90379-4 · DOI
  93. Reite, 1974, Depression in infant monkeys: Physiological correlation, Psychosom. Med., 36, 363, 10.1097/00006842-197407000-00010 · DOI
  94. Richmond, 1980, Grooming in Norway rats: The development and adult expression of a complex motor pattern, Behaviour, 75, 82, 10.1163/156853980X00573 · DOI
  95. Ritter, 1974, Saliva lost by grooming: A major item in the rat's water economy, Behav. Biol., 11, 581, 10.1016/S0091-6773(74)90935-3 · DOI
  96. Rodgers, 1967, Pathological effects of prolonged voluntary consumption of alcohol by mice, Q. J. Stud. Alcohol, 28, 618, 10.15288/qjsa.1967.28.618 · DOI
  97. Ruwe, 1983, Peptide neurohormones: their role in thermoregulation and fever, Can. J. Biochem. Biol., 61, 579, 10.1139/o83-074 · DOI
  98. Satinoff, 1976, Behavioral fever in newborn rabbits, Science, 193, 1139, 10.1126/science.959829 · DOI
  99. Schmidt, 1960, The influence of environmental temperature on the course of experimental herpes simplex infection, J. Infect. Dis., 107, 356, 10.1093/infdis/107.3.356 · DOI
  100. Sebag, 1977, Effect of temperature on bacterial killing by serum and by polymorphonuclear leukocytes, Infect. Immun., 10, 947, 10.1128/IAI.16.3.947-954.1977 · DOI
  101. Sigel, 1962, Influence of age on susceptibility to virus infections with particular reference to laboratory animals, Annu. Rev. Microbiol., 62, 257
  102. Singer, 1988, Hyperthermia induced by open-field stress is blocked by salicylate, Physiol. Behav., 36, 1179, 10.1016/0031-9384(86)90497-X · DOI
  103. Small, 1986, Influence of body temperature on bacterial growth rates in experimental pneumococcal meningitis in rabbits, Infect. Immun., 52, 484, 10.1128/IAI.52.2.484-487.1986 · DOI
  104. Smith, 1978, Human lymphocyte responses are enhanced by culture at 40°C, J. Immunol., 121, 691, 10.4049/jimmunol.121.2.691 · DOI
  105. Snowball, 1956, The effects of self-licking by cattle on infestation of cattle tick, Boophilus microplus (canestrini), Aust. J. Agric. Res., 7, 227, 10.1071/AR9560227 · DOI
  106. Stitt, 1985, A study of the variability of the febrile response of rabbits to endogenous pyrogen, J. Appl. Physiol., 59, 1254, 10.1152/jappl.1985.59.4.1254 · DOI
  107. Szczepanska-Sadowski, 1974, Plasma ADH increase and thirst suppression elicited by preoptic heating in the dog, Am. J. Physiol., 226, 155, 10.1152/ajplegacy.1974.226.1.155 · DOI
  108. Szczepanska-Sadowska, 1979, Thirst and renal excretion of water and electrolytes during pyrogen fever in dogs, Arch. Int. Physiol. Biochem., 87, 673, 10.3109/13813457909070528 · DOI
  109. Teisner, 1974, Poikilothermia and susceptability of suckling mice to coxsackie B1 virus, Nature, 247, 568, 10.1038/247568a0 · DOI
  110. Templeton, 1988, Natural disease resistance in domestic animals, J. Am. Vet. Med. Assoc., 192, 1306
  111. Thierry, 1984, Searching-waiting strategy: A candidate for an evolutionary model of depression, Behav. Neural. Biol., 41, 180, 10.1016/S0163-1047(84)90555-7 · DOI
  112. Tobler, 1984, Interleukin-1 derived from astrocytes enhances slow-wave activity in sleep EEG of rat, Eur. J. Pharmacol., 104, 191, 10.1016/0014-2999(84)90391-1 · DOI
  113. Tocco-Bradley, 1984, Zinc concentration and survival in rats infested with Salmonella typhimurium, Infect. Immun., 45, 332, 10.1128/IAI.45.2.332-338.1984 · DOI
  114. Toms, 1977, The relation of pyrexia and nasal inflammatory response to virus levels in nasal washings of ferrets infected with influenza viruses of differing virulence, Br. J. Exp. Pathol., 58, 444
  115. Toth, 1988, Alteration of sleep in rabbits by Staphylococcus aureus infection, Infect. Immunol., 56, 1785, 10.1128/IAI.56.7.1785-1791.1988 · DOI
  116. Uehara, 1987, Interleukin-1 stimulates ACTH release by an indirect action which requires endogenous corticotropin releasing action, Endocrinology, 121, 1580, 10.1210/endo-121-4-1580 · DOI
  117. Van Miert, 1982, Endotoxin-induced fever and associated hematological and blood biochemical changes in the goat: the effect of repeated administration and the influence of flurbiprofen, Res. Vet. Sci., 33, 248, 10.1016/S0034-5288(18)32345-2 · DOI
  118. Vaughn, 1980, Antipyresis: its effect on mortality rate of bacterially infected rabbits, Brain Res. Bull., 5, 69, 10.1016/0361-9230(80)90285-3 · DOI
  119. Verheijden, 1982, Plasma zinc and iron concentrations as measurements for evaluating the influence of endotoxin-neutralizing agents in Escherichia coli endotoxin-induced mastitis, Am. J. Vet. Res., 43, 724
  120. Walter, 1986, Brain temperature changes coupled to sleep states persist during interleukin-1-enhanced sleep, Am. J. Physiol., 250, R96
  121. Wannemaker, 1977, Key role of various individual amino-acids in host response to infection, Am. J. Clin. Nutr., 30, 1260
  122. Weinberg, 1984, Iron withholding: a defense against infection and neoplasia, Physiol. Rev., 64, 65, 10.1152/physrev.1984.64.1.65 · DOI · Paper page
  123. Weinstein, 1983, The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. II. Clinical observations, with special reference to factors influencing prognosis, Rev. Infect. Dis., 5, 54, 10.1093/clinids/5.1.54 · DOI
  124. Wiesbroth, 1974, The parasitic ecology of the rodent mite Myobia musculi. I. Grooming factors, Lab. Anim. Sci., 26, 725
  125. Wing, 1982, Acute starvation protects mice against Listeria monocytogenes, Infect. Immun., 28, 771, 10.1128/iai.28.3.771-776.1980 · DOI
  126. Yoshikawa, 1983, Geriatric infectious disease: An emerging problem, J. Am. Geriatr. Soc., 31, 34, 10.1111/j.1532-5415.1983.tb06285.x · DOI
  127. Zeisberger, 1985, Role of vasopressin in fever regulation and suppression, Trends Pharmacol. Sci., 6, 428, 10.1016/0165-6147(85)90203-2 · DOI

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Metadata

Authors
Hart, B. L.
Affiliations
University of California, Davis (US)
Corresponding author
Hart, Benjamin L.
ORCID
Hart, Benjamin L.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1988-06
Volume
12
Issue
2
Pages
123-137
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/s0149-7634(88)80004-6
OpenAlex
W2099555137
Cited by
2,223
References
4
Citations by year
2026: 61 · 2025: 60 · 2024: 89 · 2023: 105 · 2022: 92 · 2021: 136 · 2020: 92 · 2019: 93 · 2018: 95 · 2017: 89 · 2016: 96 · 2015: 111 · 2014: 99 · 2013: 86 · 2012: 101
FWCI
0.34
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (RR05457)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
fever, animal behavior, lethargy, anorexia, grooming, behavioral strategies, viral infection, bacterial infection, host defense
MeSH terms
Animals, Animal Diseases, Animals, Wild, Arousal, Behavior, Animal, Energy Metabolism, Feeding Behavior, Fever, Interleukin-1, Sleep, Neuroimmunomodulation

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