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Cited by 235Retinal Development and DisordersRetinal Diseases and TreatmentsGlaucoma and retinal disorders

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Visual acuity impairment in patients with retinitis pigmentosa at age 45 years or older

Grover, Sandeep, Fishman, Gerald A, Anderson, Robert J, Tozatti, Marcia S.V, Heckenlively, John R, Weleber, Richard G, Edwards, Albert O, Brown, Jeremiah·1999·Ophthalmology
DOI 10.1016/s0161-6420(99)90342-1
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Abstract

Objective To determine the severity of visual acuity impairment in patients, age 45 years or older, with either isolated or identifiable genetic subtypes of retinitis pigmentosa (RP) and Usher syndrome.Design Multicenter, retrospective, cross-sectional analysis.Participants Visual acuity data were obtained on 999 patients with different genetic subtypes of RP and Usher syndrome, age 45 years or older, from 4 major eye care centers in the United States.Intervention The best-corrected visual acuity obtained on these patients from the eye with better vision on their most recent visit was used for the analysis.Main outcome measure Best-corrected visual acuity was the main parameter analyzed for the study, and it was obtained with Snellen or Feinbloom low vision charts or with a B-VAT II monitor (Mentor).Results The final analyses were done on 982 patients (17 patients with a sector form of RP were analyzed separately). Of the 982 patients, 506 (52%) had a visual acuity of 20/40 or better, and 678 (69%) had a visual acuity of 20/70 or better in at least one eye. There were 243 (25%) patients who had a visual acuity of 20/200 or worse in both eyes. Five (0.5%) patients had no light perception in both eyes. The odds ratio for any patient having a visual acuity of 20/200 or worse in this population was 1.4 for each difference of 10 years of age. Similarly, the odds ratio of a patient having a visual acuity of 20/40 or better in at least one eye was 0.95 for a 10-year age difference.Conclusions In this large population of patients with RP and Usher syndrome from four centers, it was rare for such patients to lose all vision in both eyes. One fourth of the patients had a visual acuity of 20/200 or worse in both eyes, and more than half of the population had a visual acuity of 20/40 or better in at least one eye. These data can be used to counsel such patients on the extent of potential visual acuity impairment from their disease.

Overview

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Crossref · 10.1016/s0161-6420(99)90342-1

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Citations

Cites

Show all 21 references

Research works printed but not linked: 2

  1. Pearlman, 1979, Mathematical models of retinitis pigmentosa, Trans Am Ophthalmol Soc, 77, 643
  2. Krill, 1972, Retinitis pigmentosa, Sight Saving Review, 42, 21

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Metadata

Authors
Grover, S., Fishman, G. A., Anderson, R. J., Tozatti, M. S. V., Heckenlively, J. R., Weleber, R. G., Edwards, A. O., & Brown, J.
Affiliations
  • University of Illinois Chicago (US)
  • Universidade de São Paulo (BR)
  • University of California, Los Angeles (US)
  • Oregon Health & Science University (US)
  • The University of Texas Southwestern Medical Center (US)
  • University of Iowa (US)
Corresponding author
Fishman, Gerald A
ORCID
Venue
Ophthalmology
Publisher
Elsevier BV
Published
1999-09
Volume
106
Issue
9
Pages
1780-1785
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/s0161-6420(99)90342-1
OpenAlex
W2131014421
Cited by
235
References
21
Citations by year
2026: 11 · 2025: 17 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 19 · 2020: 21 · 2019: 14 · 2018: 19 · 2017: 13 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 4
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
Keywords
retinitis pigmentosa, Usher syndrome, visual acuity loss, best-corrected visual acuity, visual prognosis, low vision
MeSH terms
Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Hearing Loss, Sensorineural, Humans, Male, Middle Aged, Retinitis Pigmentosa, Retrospective Studies, Severity of Illness Index, Syndrome, Vision Disorders, Visual Acuity, Cohort Studies

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