Cited by 246Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsMigraine and Headache Studies

Sensory neuropeptides: their role in inflammation and wound healing

Brain, Susan D·1997·Immunopharmacology

Abstract

Vasoactive neuropeptides including substance P and calcitonin gene-related peptide (CGRP) are localised in sensory nerves which innervate blood vessels. These are the major vasoactive neuropeptides released from sensory nerve endings and both have been suggested to have roles in inflammatory and cardiovascular disease. The neuropeptides have potent effects on microvascular tone and permeability, which are seen soon after release from perivascular nerves. There is also evidence that neuropeptides can affect various activities of inflammatory cells and that sensory nerves play a role in the recovery of the healthy microcirculation during wound healing phases. This review concentrates on evidence that the neuropeptides substance P, acting via tachykinin NK1 and NK2 receptors, and CGRP, acting via CGRP1 receptors, play a pro-inflammatory role in disease and a beneficial role in wound healing. In addition, results from clinical trials of recently developed neuropeptide antagonists are discussed.

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Crossref · 10.1016/s0162-3109(97)00055-6

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Authors
Brain, S. D.
Affiliations
King's College London (GB)
Corresponding author
Brain, Susan D
Venue
Immunopharmacology
Publisher
Elsevier BV
Published
1997-10
Volume
37
Issue
2-3
Pages
133-152
ISSN
0162-3109 (ISSN-L)
OpenAlex
W2086969402
Cited by
246
References
205
Citations by year
2026: 2 · 2025: 5 · 2024: 10 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 11 · 2013: 13 · 2012: 9
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Locations
  • Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
Keywords
sensory neuropeptides, substance P, calcitonin gene-related peptide, tachykinin NK1 receptor, tachykinin NK2 receptor, CGRP1 receptor, inflammation, wound healing, sensory nerves, microvascular tone, microvascular permeability, neuropeptide antagonists, perivascular nerves
MeSH terms
Amino Acid Sequence, Animals, Humans, Inflammation, Molecular Sequence Data, Neurons, Afferent, Neuropeptides, Wound Healing

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