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Cited by 30Photodynamic Therapy Research StudiesImmunotherapy and Immune ResponsesImmunotoxicology and immune responses

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Antigen specific and nonspecific modulation of the immune response by aminolevulinic acid based photodynamic therapy

Hryhorenko, Eric A., Oseroff, Allan R., Morgan, Janet, Rittenhouse-Diakun, Kate·1998·Immunopharmacology
DOI 10.1016/s0162-3109(98)00047-2
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Abstract

Photosensitizers used normally in treating cancers have considerable potential for treatment of other diseases. One such photosensitizer is the endogenously synthesized photosensitizer protoporphyrin IX (PpIX). To better understand how protoporphyrin might be used in transplantation or in treating autoimmune diseases, information must be obtained on how the photosensitizer affects all immune cells. We used a combination of flow cytometry and in vitro activation assays (recall assays and mixed-lymphocyte reactions) to examine the effects of PpIX on the antigen specific component, lymphocytes and the non-antigen specific component, the macrophages/monocytes and dendritic cells of the immune system. Whereas, lymphocytes accumulate PpIX only when activated, both macrophages and dendritic cells accumulated PpIX immediately, without in vitro activation, as measured by flow cytometry. ALA-PDT (aminolevulenic acid-photodynamic therapy) treated adherent cells in the recall assay had a decreased capability to activate lymphocytes. By increasing the light dose in the recall assay, antigen primed lymphocytes were selectively eliminated from a population of cells. Stimulator cells in an MLR had a decreased stimulatory capacity following ALA-PDT treatment. Functional alterations are seen in both the antigen specific

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References 35 · Cited by 30

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  1. Bodel, 1977, Appearance of peroxidase reactivity within the rough endoplasmic reticulum of blood monocytes after surface adherence, J. Exp. Med., 145, 264, 10.1084/jem.145.2.264 · DOI
  2. Chowdhary, 1994, The use of transcutaneous photodynamic therapy in the prevention of adjuvant-enhanced arthritis in MRL/lpr mice, Clin. Immunol. Immunopathol., 72, 255, 10.1006/clin.1994.1139 · DOI
  3. Grunner, 1986, Inhibition of HLA-DR antigen expression and of the allogeneic mixed leukocyte reaction by photochemical treatment, Tissue Antigens, 27, 147, 10.1111/j.1399-0039.1986.tb01514.x · DOI
  4. Hammerstrom, 1979, Human macrophage differentiation in vivo and in vitro, Acta. Pathol. Microbiol. Scand. Sect. C., 87, 113
  5. Hryhorenko, 1998, Analysis and characterization of protoporphyrin IX accumulation in activated peripheral blood lymphocytes by four color flow cytometry, Photochem. Photobiol., 67, 565, 10.1111/j.1751-1097.1998.tb09456.x · DOI · Paper page
  6. Korbelik, 1996, Photofrin accumulation in malignant and host cell populations of various tumours, Br. J. Cancer., 73, 506, 10.1038/bjc.1996.88 · DOI
  7. Korbelik, 1996, The role of host lymphoid populations in the response of mouse EMT6 tumor to photodynamic therapy, Cancer Research, 56, 5647
  8. Krutmann, 1989, Inhibition of the high affinity Fc receptor (FcγRI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals, J. Biol. Chem., 264, 11407, 10.1016/S0021-9258(18)60479-X · DOI
  9. Leong, 1996, Transcutaneous photodynamic therapy alters the development of an adoptively transferred form of murine experimental autoimmune encephalomyelitis, Photochem. Photobiol., 64, 751, 10.1111/j.1751-1097.1996.tb01830.x · DOI
  10. Mookerjee, 1990, Mitogenic effect of interleukin-2 on unstimulated human T cells: an editorial review, J. Clin. Lab. Anal., 4, 138, 10.1002/jcla.1860040213 · DOI
  11. Newman, 1980, Development of functional complement receptors during in vitro maturation of human monocytes into macrophages, J. Immunol., 125, 2236, 10.4049/jimmunol.125.5.2236 · DOI
  12. North, 1993, Photosensitizers as virucidal agents, J. Photochem. Photobiol. B: Biol., 17, 99, 10.1016/1011-1344(93)80002-Q · DOI
  13. Obochi, 1997, Prolonged skin allograft survival after photodynamic therapy associated with modification of donor skin antigenicity, Transplantation, 63, 810, 10.1097/00007890-199703270-00004 · DOI
  14. Paul, W.E., 1993. Fundamental Immunology, 3rd edn. Raven Press, New York, NY.
  15. Qin, 1993, Enhanced skin allograft survival after photodynamic therapy, Transplantation, 56, 1481, 10.1097/00007890-199312000-00038 · DOI
  16. Ratkay, 1994, Photodynamic therapy; a comparison with other immunomodulatory treatments of adjuvant-enhanced arthritis in MLR-lpr mice, Clin. Exp. Immunol., 95, 373, 10.1111/j.1365-2249.1994.tb07006.x · DOI
  17. Rittenhouse-Diakun, 1995, The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor 5-aminolevulinic acid (ALA), Photochem. Photobiol., 61, 523, 10.1111/j.1751-1097.1995.tb02356.x · DOI · Paper page
  18. Romani, 1994, Proliferating dendritic cell progenitors in human blood, J. Exp. Med., 180, 83, 10.1084/jem.180.1.83 · DOI
  19. Stewart, 1994, Cell preparation for the identification of leukocytes, Methods In Cell Biology, 41, 39, 10.1016/S0091-679X(08)61708-2 · DOI
  20. Stewart, 1994, Multiparameter analysis of leukocytes by flow cytometry, Methods In Cell Biology, 41, 61, 10.1016/S0091-679X(08)61709-4 · DOI
  21. Strickland, 1997, Immune response associated with nonmelanoma skin cancer, Clinics in Plastic Surgery, 24, 637, 10.1016/S0094-1298(20)32287-2 · DOI · Paper page
  22. Thomas, 1996, Dendritic cells: origin and differentiation, Stem Cells, 14, 196, 10.1002/stem.140196 · DOI
  23. Ullrich, 1995, Modulation of immunity by ultraviolet radiation: key effects on antigen presentation, J. Invest. Dermatol., 105, 30s, 10.1038/jid.1995.7 · DOI
  24. Van Voorhis, 1982, Human dendritic cells, J. Exp. Med., 155, 1172, 10.1084/jem.155.4.1172 · DOI
  25. Wright-Browne, 1997, Physiology and pathophysiology of dendritic cells, Human Pathology, 28, 563, 10.1016/S0046-8177(97)90079-4 · DOI
  26. Yamamoto, 1991, Photodynamic immunopotentiation: in vitro activation of macrophages by treatment of mouse peritoneal cells with haematoporphyrin derivative and light, Eur. J. Cancer, 27, 467, 10.1016/0277-5379(91)90388-T · DOI
  27. Zhou, 1992, A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily, J. Immunol., 149, 735, 10.4049/jimmunol.170.2.735 · DOI
  28. Zhou, 1995, A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells, Blood, 86, 3295, 10.1182/blood.V86.9.3295.bloodjournal8693295 · DOI
  29. Zhou, 1995, Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily, J. Immunol., 154, 3821, 10.4049/jimmunol.154.8.3821 · DOI
  30. Zhou, 1996, CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells, Proc. Natl. Acad. Sci. U.S.A., 93, 2588, 10.1073/pnas.93.6.2588 · DOI

Metadata

Authors
Hryhorenko, E. A., Oseroff, A. R., Morgan, J., & Rittenhouse-Diakun, K.
Affiliations
Roswell Park Comprehensive Cancer Center (US)
ORCID
Morgan, Janet
Venue
Immunopharmacology
Publisher
Elsevier BV
Published
1998-11
Volume
40
Issue
3
Pages
231-240
ISSN
0162-3109 (ISSN-L)
DOI
10.1016/s0162-3109(98)00047-2
OpenAlex
W2024119968
Cited by
30
References
35
Citations by year
2023: 1 · 2022: 1 · 2018: 2 · 2016: 1 · 2013: 1 · 2012: 1
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P30 CA16056, P01 CA55791, P01CA055791, P30CA016056)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
5-aminolevulinic acid, photodynamic therapy, protoporphyrin IX, photosensitizers, immunomodulation, lymphocyte activation, macrophages, dendritic cells, mixed lymphocyte reaction, antigen-specific immune response, immunosuppression
MeSH terms
Aminolevulinic Acid, Dendritic Cells, HLA-D Antigens, Humans, Lymphocytes, Macrophages, Photochemotherapy, Protoporphyrins, Photosensitizing Agents

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