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Cited by 100Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychological Treatments and Disorders

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression

Londborg, Peter D, Smith, Ward T, Glaudin, Vincent, Painter, John R·2000·Journal of Affective Disorders
DOI 10.1016/s0165-0327(99)00195-0
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Abstract

Background SSRIs resolve depression slowly and may increase anxiety or insomnia. Adding clonazepam to fluoxetine sped response, raising the question of mechanism of action: reducing symptoms co-existing with depression, suppressing side-effects, and/or alleviating core depressive symptoms. Method Adult outpatients randomly assigned to double-blind treatment with fluoxetine 20 mg+placebo or fluoxetine+clonazepam 0.5-1.0 mg were assessed by a HAM-D anxiety cluster, sleep disturbance cluster, and core symptoms cluster. Results No serious AEs were noted; no cotherapy patients dropped for AEs. Cotherapy proved superior (HAM-D total, anxiety cluster, sleep disturbance cluster ANOVA P 0.20). Limitations Extended treatment and refractory depression were not addressed. Conclusions Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest.

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Crossref · 10.1016/s0165-0327(99)00195-0

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1 of 1 references verified0 citation errors · 0 not checkable

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  • In depressed outpatients, significantly more patients showed improvements in sleep disturbance with fluoxetine plus clonazepam than with fluoxetine plus placebo.

    “Significantly more patients showed improvements in sleep disturbance in the cotherapy group than with placebo, although sedation was reported more often with cotherapy than with placebo.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Londborg et al., 2000

  • Sedation was reported more often with fluoxetine plus clonazepam than with fluoxetine plus placebo.

    “Significantly more patients showed improvements in sleep disturbance in the cotherapy group than with placebo, although sedation was reported more often with cotherapy than with placebo.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Londborg et al., 2000

Citations

Cites

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Metadata

Authors
Londborg, P. D., Smith, W. T., Glaudin, V., & Painter, J. R.
Affiliations
Summit Research Network (US)
Corresponding author
Painter, John R
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2000-12
Volume
61
Issue
1-2
Pages
73-79
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/s0165-0327(99)00195-0
OpenAlex
W2046970666
Cited by
100
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 3 · 2013: 3 · 2012: 2
FWCI
3.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
clonazepam, fluoxetine, co-therapy, depression, anxiety, sleep disorders, insomnia, SSRI side effects, depressive mood, loss of interest, sedation, xerostomia, antidepressant combination therapy
MeSH terms
Adult, Aged, Anxiety, Clonazepam, Major Depressive Disorder, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Fluoxetine, Humans, Male, Middle Aged, Sleep Wake Disorders, Time Factors, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, GABA Modulators

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