Thrombophilia and pregnancy loss
Abstract
Thrombophilia is defined as a tendency to thrombosis. The association between specific thrombophilic defects--both inherited and acquired--and pregnancy loss is a rapidly developing field. However, apart from antiphospholipid antibodies (aPL), an acquired thrombophilic defect, the role of other defects in the haemostatic pathways remains to be established. In this invited review we discuss the recent advances in our understanding of aPL related pregnancy loss, the association between genetic thrombophilic mutations and pregnancy outcome and the role of whole blood haemostasis testing in the investigation of women with recurrent miscarriage.
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Toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH) and listeria infections do not fulfil the criteria for an infective agent implicated in recurrent miscarriage.
“Toxoplasmosis, rubella, cytomegalovirus, herpes simplex (TORCH) and listeria infections do not fulfil these criteria and therefore routine TORCH screening should not be undertaken.111”
From Recurrent MiscarriageGreen‐top Guideline No. 17 (2023) · cites this paper as [111]
Cites
Rai, R. S., Regan, L., Clifford, K., Pickering, W., Dave, M., Mackie, I., McNally, T., & Cohen, H. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136224 · Cited by 238 · see citing works
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Enoxaparin and aspirin therapy for recurrent pregnancy loss due to anti-phospholipid syndrome (APS)
Mohamed, K. A. A., & Saad, A. S. (2014) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2013.12.004 · Cited by 20 · see citing works
- Authors
- Regan, L., & Rai, R.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Regan, Lesley
- Venue
- Journal of Reproductive Immunology
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 55
- Issue
- 1-2
- Pages
- 163-180
- ISSN
- 0165-0378 (ISSN-L)
- OpenAlex
- W2067510837
- Cited by
- 69
- References
- 1
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Reproductive Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- thrombophilia, miscarriage, recurrent pregnancy loss, antiphospholipid antibodies, thrombosis
- MeSH terms
- Abortion, Spontaneous, Abortion, Habitual, Aspirin, Female, Heparin, Humans, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Thrombelastography, Antiphospholipid Syndrome, Thrombophilia
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