Mania: gender, transmitter function, and response to treatment
Abstract
Noradrenergic and GABA systems may be involved in mania, but there is little information about relationships between the function of these systems and response to specific antimanic treatments. We investigated relationships between indices of catecholamine or GABA system function, pretreatment mania severity and antimanic response to divalproex, lithium, or placebo. Plasma GABA and urinary excretion of catecholamine metabolites were measured before randomization to lithium, divalproex or placebo in patients hospitalized for manic episodes. Severity of mania was evaluated using the Manic Syndrome, Behavior and Ideation and Mania Rating Scale scores from the SADS-C. Multiple regression analysis showed that pretreatment plasma GABA was related to severity of manic symptoms. This relationship seemed stronger in women. Multiple regression analysis showed that pretreatment levels of urinary MHPG correlated with improvement in manic syndrome scores. These data suggest that GABA and norepinephrine may be related to different aspects of the manic state and to its pharmacologic sensitivity.
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Two trials showed that cognitive behavioral therapy facilitated tapering among chronic benzodiazepine users.
“although 2 trials showed that cognitive behavioral therapy facilitated tapering among chronic benzodiazepine users [82, 83].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [82]
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Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
Cosci, F., & Chouinard, G. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506868 · Cited by 265 · see citing works
- Authors
- Swann, A. C., Petty, F., Bowden, C. L., Dilsaver, S. C., Calabrese, J. R., & Morris, D. D.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Dallas VA Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Case Western Reserve University (US)
- Abbott (United States) (US)
- Corresponding author
- Swann, Alan C.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 1999-10
- Volume
- 88
- Issue
- 1
- Pages
- 55-61
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W1985145481
- Cited by
- 9
- References
- 35
- Citations by year
- 2023: 1 · 2020: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- mania, gender differences, plasma GABA, urinary catecholamine metabolites, MHPG, norepinephrine, noradrenergic system, GABA system, divalproex, lithium
- MeSH terms
- Adult, Bipolar Disorder, Female, gamma-Aminobutyric Acid, Humans, Male, Methoxyhydroxyphenylglycol, Middle Aged, Norepinephrine, Psychiatric Status Rating Scales, Valproic Acid, Lithium Carbonate, Treatment Outcome, Antimanic Agents
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