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In vitro generation of IL-10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines
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Signaling through NR3C1 varies depending on T cell phenotype; in effector T cells, DEXA inhibits pro-inflammatory cytokine production and proliferation.
“Signaling through NR3C1 varies depending on T cell phenotype: for example, in effector T cells, DEXA inhibits pro-inflammatory cytokine production and proliferation, potentially reducing harmful inflammation [O’Garra & Barrat, 2003].”
From Cell signaling pathways discovery from multi-modal data (2025) · cites this paper as O’Garra & Barrat, 2003
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Interleukin-10: A Key Cytokine in Depression?
Roque, S., Correia-Neves, M., Mesquita, A. R., Palha, J. A., & Sousa, N. (2009) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2009/187894 · Cited by 89
Cell signaling pathways discovery from multi-modal data
He, C., Simpson, C., Cossentino, I., Zhang, B., Tkachev, S., Eddins, D. J., Kosters, A., Yang, J., Sheth, S., Levy, T., et al. (2025) · doi:10.1101/2025.02.06.636961 · Cited by 3
Metadata
- Authors
- O'Garra, A., & Barrat, F. J.
- Affiliations
- Dynavax Technologies (United States) (US)
- ORCID
- Barrat, Franck J
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 85
- Issue
- 2
- Pages
- 135-139
- ISSN
- 0165-2478 (ISSN-L)
- OpenAlex
- W2065427225
- Cited by
- 42
- References
- 1
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2018: 2 · 2014: 2 · 2012: 2
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- regulatory T cells, IL-10, CD4+ T cells, immunosuppressants, Th1 cytokines, Th2 cytokines, Treg differentiation
- MeSH terms
- Animals, Cell Differentiation, Cholecalciferol, Dexamethasone, Humans, Immunosuppressive Agents, Signal Transduction, CD4-Positive T-Lymphocytes, Cytokines, Interleukin-10, Th1 Cells, Th2 Cells
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