COX-3: in the wrong frame in mind

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Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

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Anti-Inflammatory Action and Mechanisms of Resveratrol

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Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications

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Mechanism of Action of Paracetamol

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Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

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Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man

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Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships.

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Fever and hypothermia in systemic inflammation: recent discoveries and revisions

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Renal adverse effects of nonsteroidal anti-inflammatory drugs

Harirforoosh, S., & Jamali, F. (2009) · Expert Opinion on Drug Safety · doi:10.1517/14740330903311023 · Cited by 260 · see citing works

COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites

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Acetaminophen and the Cyclooxygenase-3 Puzzle: Sorting out Facts, Fictions, and Uncertainties

Kis, B., Snipes, J. A., & Busija, D. W. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085431 · Cited by 250 · see citing works

New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

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Cyclooxygenase-2 and its role in ovulation: a 2004 account

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Inhibitors of cyclooxygenases: mechanisms, selectivity and uses.

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Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti‐inflammatory drugs

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Paracetamol – An old drug with new mechanisms of action

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Cyclooxygenases in the skin: pharmacological and toxicological implications

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Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic

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Analysis of Cyclooxygenase 2 (COX-2) Expression During Malignant Melanoma Progression

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Cellular mechanisms of acetaminophen: role of cyclo‐oxygenase

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New insights into COX-2 biology and inhibition

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Targeting signal transduction pathways by chemopreventive agents

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PTGS2 (COX-2) −765G > C Promoter Variant Reduces Risk of Colorectal Adenoma among Nonusers of Nonsteroidal Anti-inflammatory Drugs

Ulrich, C. M., Whitton, J. A., Yu, J., Sibert, J. G., Sparks, R., Potter, J. D., & Bigler, J. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0510 · Cited by 114 · see citing works

Cyclooxygenase-3: axiom, dogma, anomaly, enigma or splice error?--Not as easy as 1, 2, 3.

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In Vitro Effects on Polydextrose by Colonic Bacteria and Caco-2 Cell Cyclooxygenase Gene Expression

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Cyclooxygenase: Past, present and future. A tribute to John R. Vane (1927–2004)

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Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray?

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COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells

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Mechanism of the Antinociceptive Effect of Paracetamol*

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Prostaglandin and the Suppression of Phagocyte Innate Immune Responses in Different Organs

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Cloning and Characterization of Cyclooxygenase-1b (Putative Cyclooxygenase-3) in Rat

Snipes, J. A., Kis, B., Shelness, G. S., Hewett, J. A., & Busija, D. W. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.079533 · Cited by 82 · see citing works

An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact

Mallet, C., Desmeules, J., Pegahi, R., & Eschalier, A. (2023) · Journal of Pain Research · doi:10.2147/jpr.s393809 · Cited by 83 · see citing works

The involvement of a cyclooxygenase 1 gene-derived protein in the antinociceptive action of paracetamol in mice

Ayoub, S. S., Colville-Nash, P. R., Willoughby, D. A., & Botting, R. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.061 · Cited by 79 · see citing works

Cloning, Expression, and Functional Characterization of Human Cyclooxygenase-1 Splicing Variants: Evidence for Intron 1 Retention

Qin, N., Zhang, S.-P., Reitz, T. L., Mei, J. M., & Flores, C. M. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.090944 · Cited by 77 · see citing works

From NSAIDs to Glucocorticoids and Beyond

Sinniah, A., Yazid, S., & Flower, R. (2021) · Cells · doi:10.3390/cells10123524 · Cited by 80 · see citing works

The Molecular Toxicology of Acetaminophen

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Cyclooxygenase-2 Inhibitors: A Painful Lesson

Sanghi, S., MacLaughlin, E. J., Jewell, C. W., Chaffer, S., Naus, P., Watson, L. E., & Dostal, D. E. (2006) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152906777441803 · Cited by 73 · see citing works

Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: A time course study

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Cyclooxygenase-3 Gene Expression in Alzheimer Hippocampus and in Stressed Human Neural Cells

Cui, J.-G., Kuroda, H., Chandrasekharan, N. V., Peláez, R. P., Simmons, D. L., Bazan, N. G., & Lukiw, W. J. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000035809.70905.8a · Cited by 65 · see citing works

COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics?

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Signal Transduction Pathways in Cancer Development and as Targets for Cancer Prevention

Bode, A. M., & Dong, Z. (2005) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(04)79005-4 · Cited by 64 · see citing works

Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis

Weinheimer-Haus, E. M., Jemioło, B., Carroll, C. C., Harber, M. P., Haus, J. M., Burd, N. A., LeMoine, J. K., Trappe, S. W., & Trappe, T. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00718.2006 · Cited by 60 · see citing works

Pain and osteoarthritis: new drugs and mechanisms

Hinz, B., & Brune, K. (2004) · Current Opinion in Rheumatology · doi:10.1097/01.hco.0000136130.95746.14 · Cited by 58 · see citing works

The Role of Resveratrol in Eye Diseases—A Review of the Literature

Bryl, A., Falkowski, M., Zorena, K., & Mrugacz, M. (2022) · Nutrients · doi:10.3390/nu14142974 · Cited by 49 · see citing works

Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones

Hinz, B., & Brune, K. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_3 · Cited by 49 · see citing works

Cyclooxygenases 1, 2, and 3 and the Production of Prostaglandin I2: Investigating the Activities of Acetaminophen and Cyclooxygenase-2-Selective Inhibitors in Rat Tissues

Warner, T. D., Vojnovic, I., Giuliano, F., Jiménez, R., Bishop‐Bailey, D., & Mitchell, J. A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.063875 · Cited by 48 · see citing works

Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants

Pisoschi, A. M., Iordache, F., Stanca, L., Cimpeanu, C. L., Furnaris, F., Geicu, O. I., Bîlteanu, L., & Șerban, A. I. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116075 · Cited by 48 · see citing works

Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous system

Kis, B., Snipes, J. A., Bari, F., & Busija, D. W. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.03.015 · Cited by 43 · see citing works

Expanding the febrigenic role of cyclooxygenase-2 to the previously overlooked responses

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Acetaminophen Recruits Spinal p42/p44 MAPKs and GH/IGF-1 Receptors to Produce Analgesia via the Serotonergic System

Bonnefont, J., Daulhac, L., Etienne, M., Chapuy, E., Mallet, C., Ouchchane, L., Deval, C., Courade, J.-P., Ferrara, M., Eschalier, A., et al. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.025775 · Cited by 39 · see citing works

Cyclooxygenase variants: The role of alternative splicing

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Bitterness Evaluation of Acidic Pharmaceutical Substances (NSAIDs) Using a Taste Sensor

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The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain.

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COX-3: Fact or fancy?

Berenbaum, F. (2004) · Joint Bone Spine · doi:10.1016/j.jbspin.2004.02.003 · Cited by 30 · see citing works

Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

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Characterization of inhibition of platelet function by paracetamol and its interaction with diclofenac in vitro

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Resting and arecoline‐stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase‐2 knockout mouse

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New insights into eicosanoid biosynthetic pathways: implications for arthritis

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The Effect of Paracetamol and Tropisetron on Pain: Experimental Studies and a Review of Published Data

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Nonsteroidal Anti-inflammatory Drugs, Acetaminophen, and COX-2 Inhibitors

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Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea?

Girolamo, G. D., Sánchez, A. J., Santos, A. R. D. L., & González, C. D. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.3.561 · Cited by 23 · see citing works

Anti-Inflammatory Properties of Resveratrol

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Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells

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Acetaminophen: A Central Analgesic Drug That Involves a Spinal Tropisetron-Sensitive, Non–5-HT3 Receptor-Mediated Effect

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COX-3: Uncertainties and controversies

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Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes

Ayoub, S. S., & Flower, R. J. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172609 · Cited by 19 · see citing works

Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE)

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A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis

Moreira, V., Gutiérrez, J. M., Amaral, R. B., Lomonte, B., Purgatto, E., & Teixeira, C. (2010) · Toxicon · doi:10.1016/j.toxicon.2010.12.004 · Cited by 19 · see citing works

Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats

Wood, R. C., Wyatt, J. E., Bullins, K. W., Hanley, A. V., Hanley, G. A., Denham, J. W., Panus, P. C., & Harirforoosh, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.035 · Cited by 19 · see citing works

Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress

Foster, J., Mauger, A. R., Govus, A., Hewson, D., & Taylor, L. (2017) · Clinical Drug Investigation · doi:10.1007/s40261-017-0560-x · Cited by 13 · see citing works

Antipyretic analgesics: basic aspects

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Antipyretic analgesics: basic aspects

Zeilhofer, H. U., & Brune, K. (2006) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-10278 · Cited by 12 · see citing works

Synthesis and Preliminary Pharmacological Evaluation of Esters and Amides Derivatives of Naproxen as Potential Anti-Inflammatory Agents

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Human cyclooxygenase-1b is not the elusive target of acetaminophen

Censarek, P., Freidel, K., Hohlfeld, T., Schrör, K., & Weber, A. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.079 · Cited by 10 · see citing works

Nonsteroidal Anti-inflammatory Drugs

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Evidence of COX-1 and COX-2 expression in Kaposi’s sarcoma tissues

Rossiello, L., Ruocco, E., Signoriello, G., Micheli, P., Rienzo, M., Claudio Napoli, A., & Rossiello, R. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.03.016 · Cited by 7 · see citing works

Neurodegeneration from Drugs and Aging‐Derived Free Radicals

Ramkissoon, A., Shapiro, A. M., Loniewska, M. M., & Wells, P. G. (2013) · doi:10.1002/9781118355886.ch10 · Cited by 6 · see citing works

Le paracétamol : un ancêtre plein d’avenir

Mallet, C., Barrière, D. A., & Eschalier, A. (2012) · Therapies · doi:10.2515/therapie/2012039 · Cited by 5 · see citing works

Part I. Mechanisms of actions and metabolism of acetaminophen related to the neonatal brain

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MOLECULAR DOCKING STUDY OF THE AFFINITY OF CYP2C9 AND CYP2D6 FOR IMRECOXIB

Yao, Y., Han, W., Zhou, Y., Li, Z., Li, Q., & Zhong, D. (2007) · Journal of Theoretical and Computational Chemistry · doi:10.1142/s0219633607003179 · Cited by 5 · see citing works

The discovery and preclinical pharmacology of JNJ-10450232 (NTM-006), a centrally penetrant, non-opioid structural analog of acetaminophen with comparable analgesic and anti-pyretic properties but no evidence of hepatotoxicity

Flores, C. M., Carson, J. R., Codd, E. E., Dax, S. L., Kuffner, E. K., Stahle, P. L., Neff, R. A., & Eichenbaum, G. E. (2025) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2025.105830 · Cited by 3 · see citing works

Paracetamol and ibuprofen in the treatment of pain and fever in children: modern views on the choice of a drug

Zakharova, I. N., Berezhnaya, I. V., Pupykina, V. V., Gostyukhina, A. D., & Dubovets, N. F. (2023) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2023-367 · Cited by 3 · see citing works

Quantitative analysis of the scientific literature on acetaminophen in medicine and biology: a 2003–2005 study†

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Synthesis and Preliminary Pharmacological Evaluation of Aminobenzensulfonamides Derivatives of Mefenamic Acid as a Potential Anti-inflammatory Agents

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Schmerztherapie mit antipyretischen Analgetika

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Nonsteroidal Anti-Inflammatory Drugs

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Actualización en la Farmacología de los AINES (Anti-Inflamatorios No Esteroideos)

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La COX-3 existe-t-elle ?

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The molecular and biological basis for COX-2 selectivity

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Efeitos de toxinas com estrutura de fosfolipase A2, isoladas do veneno de Bothrops asper e Crotalus durissus terrificus, e dos respectivos venenos, sobre a expressão de ciclooxigenases e produção de prostaglandinas

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Regulation of cyclooxygenase gene expression by glucocorticoids in cardiomyocytes

Sun, H. (2007) · UA Campus Repository (The University of Arizona)

Development of Cyclooxygenases in the Treatment of Pain, Fever and Inflammation.

Asif, M. (2014) · Research and reviews : journal of pharmaceutics and nanotechnology

The Role of Prostaglandin H Synthase (PHS) Bioactivation and Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)-Mediated Protection in Endogenous and Methamphetamine-initiated Neurotoxicity

Ramkissoon, A. (2012) · TSpace (University of Toronto)

Chemopräventive Effekte von n-3 mehrfach ungesättigten Fettsäuren und Fisch in humanen Kolonzellen

Haber, J. E. (2010) · Common Library Network (Der Gemeinsame Bibliotheksverbund)

Nonsteroidal Anti-inflammatory Drugs, Acetaminophen, and COX-2 Inhibitors

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